Story TimelineHow to install iOS 13, iPadOS & macOS Catalina – and why you should waitiOS 13 beta 3 now available: Here’s what’s newEpic tells Fortnite players to hold off on iOS 13 beta for now This update will come with a new icon for voice messages in the Messages app. So make sure when you download and load the software, you head into Messages to make certain you’re recognizing the new icon – and not just assuming that Voice Messages are gone completely. This update will bring a few more updates in the visual space just like that – so keep your wits about you!There’s a new Rearrange Apps button that’ll appear when you activate the function. The way you’ll do this is the same as it ever was: Rearrange Apps by long-pressing any one app on your home screen. You’ll find a new button that’ll ask if you wish to actually rearrange apps or not.If you’re using the iPad version of this software, you’ll find a blinking line showing which side of your split-screen is receiving attention – specifically with text. You’ll also find a new pill-shaped indicator of which side of the split-screen you’re inputting on currently.If you’re in the beta and head into Settings, Health, Headphone Audio Levels, you’ll see a new set of explanations for what’s going on in the latest Beta in this specific area. Perhaps strangest of all, you’ll find the FaceTime Attention Correction feature in play. This is the not-at-all-creepy feature that’ll change the direction of your eyes when you’re speaking in FaceTime, so it looks like you’re looking right at the person to whom you are speaking. When’s the last time you had your eyes redirected automatically? To attain this update, you’ll need to head into the iOS Public Beta page at Apple and tap forth! If you’ve already done this, simply head into your Settings and get yourself the latest Software Update. It SHOULD be the iOS 13 Beta 3 to which we’ve been referring – if not, just wait a bit longer! Today the folks at Apple made final the iOS 13 BETA release for the public, allowing pretty much anyone to take a peek on their own iPhone. This means users of the iPhone XS, iPhone XS Max, XR, 8, 8 Plus, 7, 7 Plus, 6s, and 6s Plus will be able to download the software immediately, if they do so dare. There’s also a new iPadOS 13 (iOS 13 for the iPad, that is to say) out and available right now, too – in Beta form.
Reviews are pretty mixed, and so are the phone’s specs. Even by late 2016’s standards, the Kodak Ektra is a bit dated as far as smartphones go. The MediaTek Helio X20 running inside is hardly the latest and is matched with only 3 GB of RAM. The 5-inch display, though handy, reaches only 1920×1080 pixels. While good enough for most, that does mean that you won’t be seeing the photos and videos you just captured in all their glory. Kodak is a name you would immediately associate with cameras but with this generation’s obsession with smartphone, it couldn’t but help dip its toes into that market as well. That product is the Kodak Ektra which is finally making its way to the US. But with nearly half a year’s time since it was first announced, the Ektra faces a very tough battle against the market’s top contenders for the best smartphone camera. The camera sounds great, at least on paper. It has a 21 megapixel fast focus sensor, an F/2.0 lens, phase detect autofocus, optical image stabilization, and dual LED flash. That said, early reviews of that camera seem to hint that the hardware is hampered by a mediocre camera app, despite offering the bells and whistles of an “advanced” manual mode.One thing going for the Kodak Ektra is its design. At least if you go for that look. It definitely looks like a digital camera first and a smartphone second, including a protruding grip that photographers are comfortable with. Kodak is even making available leather cases that are designed for cameras rather than phones, including a pink one from fashion designers Pop & Suki. The Kodak Ektra smartphone will at least be priced accordingly, selling for only $399, unlocked and SIM free. That’s quite a drop from its initial $549 price tag. It is, however, going up against the likes of the HTC U11, the Google Pixel, and the Samsung Galaxy S8, all of whom occupy top spots in DxOMark’s famous list.
The device goes by the name Samsun Gear Sport, and it would seem to be a fairly decent bet that it’s coming with rugged intentions. The backside image we’ve got below comes from the FCC VIA TL, showing where regulatory labels will be located. In this image we can see a device that’s nearly identical to the Samsung Gear S3 – save some small differences.One rather noticeable difference is the appearance of the name SAMSUNG GEAR SPORT. This should be a FAIR indicator of the name of the device as it heads to the production floor. Also present in the report is a note about Bluetooth Low Energy certification issuance. This certification was issued all the way back on August 7th (that’s just this week.)The original Samsung Gear S3 was revealed back in August of 2016. That MIGHT mean that Samsung is now on a two-year-refresh cycle for their most major wearable device. Instead of releasing some sort of “slightly better” version every other year, the Sport watch may come into play. Story TimelineiPhone 8 and Galaxy Note 8 aren’t playing the same gameGalaxy Note 8 launch date has been tippedGalaxy Note 8 may come with a welcome surpriseGalaxy Note 8 release day 3D-touch tippedGalaxy Note 8 stock wallpapers leak: see and download them here The next Samsung event is all but guaranteed to be home to the Galaxy Note 8 – but that’s not all. Today we’ve got word that the next Samsung wearable device – a perfect companion for the Galaxy Note 8, as it were – just passed through the FCC. This comes not long after the same device passed Bluetooth certification, meaning – or at least indicating – that it’s right on the verge of being revealed by Samsung in full. Above you’ll see our original Samsung Gear S3 hands-on video as recorded a bit less than a year ago. The event in which this device was first revealed took place during IFA 2016. This year IFA 2017 is scheduled for a similar span of days, and Samsung’s event for the Galaxy Note 8 – and likely this Sport watch – is set for August 23rd. We’ll be there LIVE in effect!
HMD Global has a pretty gosh-darned good track record of bringing updates to Android devices – especially lately. HDM Global phones of all sorts have been getting Security Updates lately, at least. Security Updates are the most essential updates to Android devices – followed closely by full OS updates for new and tweaked features.The KEY here will be timing. If HMD Global can stick to updates – and make that a big priority once their first wave of Nokia phones proliferate the earth – they’ll make a Motorola-like impact. Back when the first Moto X and Moto G were first released, the then-Google-owned Motorola had updates REAL quick.Android Oreo will quite likely come to Nokia 3, Nokia 5, Nokia 6, and Nokia 8. Cross your fingers HMD Global keeps Sarvikas’ promise! According to Nokia dot com, Nokia and/or HMD Global promises “You get an experience that’s focused and clutter-free, and we’ll make sure you keep getting regular updates, so you’ll always stay on top of features and security.” In an interview with NDTV, Sarvikas promised each of these phones would get two years of Android updates. The article includes this promise twice, but does not write the exact words used by Sarvikas for the two-year update promise.I’d believe in the two-year promise only if the smartphone included that promise in writing at the point of purchase. If updates are important to you – beyond security updates, that is – be sure to get that promise when you buy.Those users that are already on the update list and want to update to Android 8.0, head over to our How to download the Android 8.0 Oreo update now guide. It’s quite simple, really – mostly just heading to Settings – System – System updates. Otherwise head to Google Developers to see if the device list miraculously contains a Nokia phone – likely it still just contains Nexus and Pixel devices as such. Android Oreo was announced to be coming to all current-age Nokia smartphones over the weekend. The timing of these updates is not yet known, but Juho Sarvikas, Chief Product Officer for HMD Global seems to believe that the company is ready and capable of bringing the newest version of Oreo to all new Nokia phones. HMD Global is the company that currently licenses the Nokia brand name to create smartphones with what remains of the original Nokia company. Story TimelineAs Nokia 8 nears, HMD’s veteran CEO suddenly departsNew Nokia 3310 torture test: see how it faresNokia 8 prototype says hello in leaked imagesNokia 8 Copper Gold model leakedNokia 2 entry level Android phone is apparently realNokia 8 release specs just droppedNokia 8 Bothies aren’t the camera gimmick we wantedNokia 8 might not launch in US or China
What’s this third device I speak of today? It’s a magician – a sort of device that existed in earlier tests of the latest version of Android, then disappeared for a while. It’s re-appeared in the same testing bin that the other two Pixel 2 devices first appeared – AOSP. There, we see the re-appearance of Muskie.SEE TOO: Pixel 2 XL LG-made screen saga keeps getting worseThis third Pixel device is not confirmed by Google, nor HTC, or anything like that. Instead, we’re looking at codes dug up by XDA which show the device as HTC-made, “manufacturer” Google, with a massive battery inside. This device would be the beast of the group, carrying with it a battery that’s 3830 mAh large. That’s bigger than the Google Pixel 2 XL, a device with a 3520 mAh battery inside.What’s more, this device has the same dots per inch as the larger Pixel released this year. That would seem to indicate that it’s a device with a very, very similar build – if not the same display with a different body. That’s very interesting – very interesting indeed.As this device is lumped in with codes for Walleye and Taimen – both previously released Pixel devices. Over at Droid Life today, they’ve got a tip on the next generation of Pixel devices, too – Albacore and Blueline. If that’s true, why would Google still be working on Muskie?Is it a half-step device with a larger battery made to be released halfway between this year’s Pixels and the Pixels of 2018? Or is this some sort of magical third category? Maybe a beast of a phone running Android One?Have a peek at the timeline below to see what other recent Google-made oddities have popped up. And stay tuned as we continue to unravel this fishy mystery! Story TimelinePixel 2 XL, iPhone 8 Plus drop tests push glass to the limitsPixel 2 XL screen saga keeps getting worsePixel 2, 2 XL has some audio issues, here’s a temporary fixPixel 2 teardown shows unusual waterproofing methodPixel 2 unit fails quality control, still shipped to buyerGoogle Lens app download out for Pixel and rooted Android It would seem fitting that this week another HTC-made Pixel 2 XL device would be found. This, a week in which the LG-made Google Pixel 2 XL (already out in the wild – see link below) is the subject of display-based controversy. This, a week in which the HTC-made Pixel 2 has had few to no negative reports – just the opposite – the smaller device has everything the larger one does, with a smaller display whose colors and viewing angles are all on-point.
Samsung’s test involved a 5G router and a 5G Radio, plus a virtualized core and virtualized RAN. The test happened on a train running between two stations that were about 1 mile apart from each other. The on-board 5G router was used to download an 8K video and to upload a 4K video sourced from a camera mounted on the train. KDDI is eyeing 5G tech as a way to revolutionize trains.Talking about this, KDDI’s Senior Managing Executive Officer Yoshiaki Uchida said, “With 5G expected to bring railway services to a whole new dimension, the success of today’s demonstration in everyday locations such as a train and train station is an important milestone indicating 5G commercialization is near.” KDDI plans to launch 5G by 2020; it opens the doors to many potential benefits, such as better on-board WiFi and a better infotainment experience on the trains. For its part, Samsung has been putting ample effort into developing and testing 5G technologies. A recent report claimed that Samsung has been working with the U.S. military to develop and test a 5G network prototype. The technology is reportedly of interest to the military as a way to supply units with high-speed and relatively portable Internet connectivity while out in the field. SOURCE: Samsung News Samsung recently tested 5G on a train traveling at about 62MPH and was able to hit a peak speed of 1.7Gbps. The company called its test, which was performed with Japan’s KDDI, a success, saying it achieved successful downlink and uplink handover in addition to the crazy peak speed. The test took place in Saitama, Japan, on October 17 through October 19.
The FCC has granted SpaceX’s application to use satellites for providing Internet service to regions around the world. According to the FCC, this is the first approval for a “US-licensed satellite constellation” that will use low-Earth orbit satellites to offer “broadband services.” The system may contain more than 4,000 satellites, and was confirmed by SpaceX back in May 2017. READ: This is SpaceX’s plan to beam internet to the whole worldThe FCC wants to provide all regions of the US with broadband Internet service, which means hitting speeds of at least 25Mbps. SpaceX may help hit that goal with its satellite-based plan, which would use satellites to beam high-speed Internet to the United States and other countries all over the world. According to the approval letter published by the FCC today, the system was proposed to contain 4,425 satellites.The Internet service won’t be free, so don’t get your hopes up. However, such a system could provide an unprecedented level of Internet access to places that historically have had poor service options. Many rural regions in the US only have access to dial-up or DSL, and some people are forced to depend on aging cellular networks or low-quality satellite services to get Internet access.AdChoices广告Of course, the system would also cover other places around the world that have a lack — or complete absence — of adequate Internet service. Before offering its network, though, SpaceX had to get approval to send the satellites up, and that’s where the FCC’s authorization comes in. The Commission has previously approved similar requests from Telesat, OneWeb, and Space Norway.The FCC hints that it has outstanding requests from other companies with similar plans, too. “These approvals are the first of their kind for a new generation of large, nongeostationary satellite orbit, fixed-satellite service systems,” the agency says, “and the Commission continues to process other, similar requests.”SOURCE: FCC
Microsoft suggests they’ve brought the original Surface Hub to more than 5000 customers across 25 markets. “Over half of Fortune 100 companies have purchased Surface Hubs to improve team’s efficiency and how they collaborate,” said Chief Product Officer at Microsoft, Panos Panay, “breaking down barriers and creating real business value.”This device has the same 2:3 aspect ratio as other Surface products. So it’ll look and act like one massive Surface tablet. Even if you’re an individual with no real use for such a massive tablet – you might just find yourself wanting one. Good luck to you in finding one to buy.Businesses and other “select commercial customers” will be able to purchase this device in the year 2019. This monster will be tested by select commercial customers starting this year. Release pricing is not yet available – but if it costs anything like the first Surface Hub, everyday individuals will probably want to go ahead and pass. This machine is made to make the most of software like Microsoft Whiteboard, Microsoft Teams, and Office 365. In addition to working on its own, this big computer can be tiled together with up to 4 screens at once, relatively seamlessly. Microsoft’s releasing this device with its own Steelcase-made accessories like a rolling stand and mounts for walls.Under the hood is a 4K camera that’s able to rotate with the device. Integrated speakers make this as all-in-one a device as you could ask for at this size. Far field mic arrays make it so everyone in the room can be heard when there’s a video call. Businesses in need of wall-based Windows 10 devices rejoice, there’s a new Surface Hub 2 in town. This device brings out the best bits of the Surface Hub 1 and advances all the parts that needed advancing. This beast features a 4K+ 50.5” multi-touch display and it’s made to get business done.
The cars are based on GM’s regular Bolt EV. That’s an all-electric hatchback, with 238 miles of EPA-certified range. For autonomous purposes, the car is customized with LIDAR laser rangefinders, extra cameras and other sensors, and new processing power to crunch all the data in real-time. Cars have been in testing – in association with Cruise Automation, the self-driving startup GM acquired – in San Francisco, CA; Scottsdale, AZ; and Detroit, MI. Trials on public roads began in June 2016. GM has also cut a deal with ride-sharing firm Lyft to work on the technology together, with the eventual goal of deploying autonomous cabs out into public service. What’s really important, though, is not just what the autonomous Bolt EV are being built with, but how they’re being built. GM was the first automaker to assemble its self-driving prototypes at a mass-production facility, rather than in a more boutique operation as might commonly be the case for small-run vehicles. That takes place at the Orion Township plant, which started the next-generation production run in January 2017. While the numbers involved may still be small today, it’s part of GM’s vision for shifting autonomous vehicles into the mainstream down the road. “To achieve what we want from self-driving cars, we must deploy them at scale,” Kyle Vogt, CEO of Cruise Automation, said of the milestone. “By developing the next-generation self-driving platform in San Francisco and manufacturing these cars in Michigan, we are creating the safest and most consistent conditions to bring our cars to the most challenging urban roads that we can find.”That’s still some way off, of course. However GM has also opted to accelerate availability of its regular Bolt EV. Though the car was always planned for a roll-out across all fifty states in the US, that was a staggered affair. Now, Steve Majors, marketing director for cars and crossovers at Chevrolet, told Automotive News, the timescales are being shortened. NOW READ: 2017 Chevrolet Bolt EV ReviewIn fact, nationwide orders for the Bolt EV began on June 1, he confirmed. Delivery across the US will be rolling out by August. Among the factors which enabled that was faster than expected installation of training and maintenance upgrades at dealerships, as well as the mandatory installation of DC fast-charging stations that Chevrolet required. 130 new autonomous Bolt EV test cars have rolled off GM’s production line, the automaker has announced today, each fitted with the new version of its self-driving hardware. The expanded Chevrolet fleet will join the 50+ current-gen autonomous Bolt EV cars which GM has already been using to refine its self-driving platform. They’re currently navigating the streets in three US states. Story TimelineChevrolet plans “thousands” of autonomous Bolt EV from 2018 say insidersGM begins expanding its autonomous Chevy Bolt fleet5 Things we learned on our Chevrolet Bolt winter road trip
Here’s the new Galaxy Fit E render, extracted from the APK. Also, here are renders of the Galaxy Watch Active and Galaxy Buds, but you’ve already seen those before. pic.twitter.com/jU9tj1id29— Mishaal Rahman (@MishaalRahman) February 15, 2019 It is, however, the first time we’re seeing the Galaxy Fit, billed to be the Fitbit Charge 3’s new rival. Just like with the Galaxy Watch Active, Samsung has made a rather drastic design change, throwing away the curved screen for a flat one. We’ll have to see what else the wearable has in store and whether the new aesthetic will make it more appealing to buyers. AdChoices广告 It seems that Samsung is truly retiring the Gear brand, putting all its mobile products under a single “Galaxy” name, regardless of form or operating system. That has started with the Gear Watch, now Galaxy Watch, and the rumored Galaxy Buds that will succeed the Gear IconX. Now it seems that Samsung itself has accidentally confirmed that the Gear Fit trackers will also experience a change, but the new Galaxy Fit and Galaxy Fit e will bring more than just a new name. Rumors of Samsung’s next fitness wearable started floating around last month when the name was spotted together with the Galaxy Buds. Given that thee latter is all but confirmed, it goes to reason that the Galaxy Fit is also real. Thanks to Samsung pushing some things to its Galaxy Wearable (formerly Samsung Gear) app, now we know how close all of those were to reality.The app shows the selection of new wearables you can add, including three that haven’t even been released yet. We’ve seen the Galaxy Watch Active, of course, and this image of the smartwatch confirms the lack of a bezel ring. There’s also the Galaxy Buds, coming in black and white colors. The app makes mention of a Galaxy Fit e model, which could be a more wallet-friendly version of the fitness tracker. If so, then there’s also a chance that Samsung has indeed adopted that naming convention and will call the Galaxy S10 Lite as the Galaxy S10e instead.
Qualcomm has won a legal case against Apple in the Southern District of California, the company announced. The case involved a lawsuit Qualcomm filed against Apple in July 2017 alleging the company had infringed upon some of its smartphone tech patents. A jury awarded Qualcomm $31 million in damages for three patents involving ‘popular smartphone features.’ The three patents at the heart of the legal battle include US Patent No. 8,838,949, 9,535,490, and 8,633,936. The patented technologies cover flashless booting, which enables a phone to connect to WiFi rapidly after being turned on, tech that enables phone apps to quickly get data to/from the Internet, and a method to get high mobile game performance and visuals while increasing battery life.The jury found that Apple infringed upon two of these patents with its iPhone 7, iPhone 7 Plus, iPhone 8 and 8 Plus, and the iPhone X. The latter three models were also found to infringe upon the third patent covered by the lawsuit, No. 8,633,936. Qualcomm’s executive VP and general counsel Don Rosenberg praised the ruling, saying:The technologies invented by Qualcomm and others are what made it possible for Apple to enter the market and become so successful so quickly. The three patents found to be infringed in this case represent just a small fraction of Qualcomm’s valuable portfolio of tens of thousands of patents. We are gratified that courts all over the world are rejecting Apple’s strategy of refusing to pay for the use of our IP.The $31 million in damages works out to $1.41 per iPhone found to infringe one or more of the three patents. That’s not a terribly burdensome figure for Apple, which tipped over the $1 trillion valuation milestone in 2018. However, this marks a solid score for Qualcomm, which is no stranger to legal tussles. Story TimelineQualcomm Quick Charge wireless power now works with Qi standardQualcomm just revealed the 5G chip to supercharge 2020Apple hits back at Spotify after antitrust complaint
Toyota has announced the 2019 TRD Pro series trucks and SUVs. For 2019 the series will include the Tundra, 4Runner, and Tacoma. All the Pro models will feature Fox 2.5-inch Internal Bypass Shocks. The 2019 model trucks will be available this fall and each of the Pro vehicles will be offered in three colors including Super White, Midnight Black Metallic, and Voodoo Blue. SOURCE: Toyota That blue hue is a TRD Pro exclusive color found on no other Toyota trucks. Each of the vehicles gets Fox shocks tuned exactly for it at TRD. Toyota says that the design of the shocks allows for a plush ride on the roads but stiffens to prevent bottoming during hard use. The Tacoma TRD Pro uses shocks with 46mm piston and 8 bypass zones combined with springs that lift the front of the truck by an inch.That vehicle has Entune Premium JBL audio with a subwoofer and integrated NAV. Rigid Industries fog lights are included and the truck rides on 16-inch TRD Pro black wheels. A TRD Desert Air Intake is optional and helps reduce dust the truck might slurp up by moving the intake up by the windshield from the fender well. The Tundra TRD Pro uses Fox shocks and TRD springs for 2-inches of front lift. This truck has Rigid Industries fog lights, LED headlights, and LED accent lights. It rides on 18-inch BBS forged wheels and has special TRD touches on the interior. The 4Runner TRD Pro gets the same Fox shocks with a 1-inch lift out front. It can be fitted with the Premium JBL Audio system and gets several TRD touches on the inside.AdChoices广告The three vehicles all have the Toyota 36-month/36,000-mile warranty. All the models also have the Star Safety System with Vehicle Stability Control (VSC), Traction Control (TRAC), Anti-lock Brake System (ABS), Electronic Brake-force Distribution (EBD), Brake Assist (BA) and Smart Stop Technology (SST). Tundra and Tacoma also get, “Toyota Safety Sense P (TSS-P), which features Pre-Collision System with Pedestrian Detection (PCS w/PD), Lane Departure Alert (LDA) with Sway Warning System (SWS), Automatic High Beams (AHB) and high-speed Dynamic Radar Cruise Control (DRCC).
Bicycle rides recorded in Strava will not, from this point forward, be reported to Relive. Not through the group’s official API, anyway. If Relive wants to gain access to Strava data from now on, they’ll need to get extra creative. Before now, users would be able to quite easily create an automatically-compiled piece of media based in Relive using their Strava data, GPS, and photos taken during said trip. The final product was both interesting and highly share-friendly. We live in a socially networked in a highly addicted fashion sort of world, after all.Work was done between the two to fix whatever problems Strava had with how Relive handled user data. Strava said in a statement that “The current version of Relive violates several of the terms that we ask of API partners,” and that “We’ve worked hard with Relive to try to fix this, but they have ultimately chosen not to make the changes needed to honor their agreement.”AdChoices广告The statement from Relive posted a very detailed bit of documentation this week, making the case that it feels like they’re taking crazy pills because this relationship is just bananas. “After launching our first social features, we received a very unexpected message threatening to pull the plug. Given our long-term partnership, we immediately rolled back the changes like they requested,” said a Relive representative. After working with the company for over three years, Relive suggested that Strava seems to have had a major change of heart about a great many things. Maybe some lawyers jump into the party? “We then tried to call, email, and talk this out with Strava,” said Relive. “No response, except for new ultimatums and threats about our existing features they’ve applauded for years.”Bummer, for all those involved on the biking end. Users of Relive can still use the service, even without Strava – if they head to the upload page on their desktop or just record their activities straight through the Relive app. They can also continue to use devices from brands like Garmin, Suunto, Polar, or any other partnered group. UPDATE: Relive works with the following tracker apps: Runtastic, MapMyRun, MapMyWalk, MapMyRide, MapMyHike, Endomondo, Garmin Connect, Suunto, Apple Health (Watch) and Polar Flow account. Both Strava and Relive have made statements on their recent breakup, suggesting that the other was the one that was at fault. According to Relive, they worked with Strava and followed Strava’s recent takedown request – but were blocked from the API nonetheless. Strava said Relive was simply abusing its API. Story TimelineStrava fitness app arrives for Apple Watch Series 2Strava fitness tracking app reveals location of military basesFitness tracker Strava reveals names, locations, heart rates
Mechanical endpoint range for pan axis control is 360° continuous rotation. Mechanical endpoint range for tilt axis control is between -95° and +220°, and roll axis control is -202.5° to +112.5°. Controlled rotation range for pan axis control is the same as mechanical endpoint range, while tilt axis is down to -90° to 145°. Controlled rotation range for roll axis control is plus or minus 30°.The battery inside this gimbal has a capacity of 2450mAh. That COULD be a very good thing – depending on how good this machine manages power. We’ll only know for sure once we get one in for review! DJI says the battery can last for up to 11 hours, which seems pretty incredible! This machine can be attained from DJI online for approximately $440 USD on its own. There’s also a “pro combo” that adds an rss splitter, screw, focus gear strip, focus wheel, focus motor rod mount, and a focus motor for $540. Both versions are available starting today. Today DJI introduced a new $440 gimbal that allows mirrorless camera users to take command of stabilization in videos of all sorts. This machine is simple-to-use, relatively small, and right on the high end of all the pro points. DJI suggests on their site that “due to limited new product availability,” they’ll only sell two units to each prospective customer. This machine is able to work with a wide variety of cameras and accessories – pretty much anything that’ll fit with its holes and/or ports. Accessory connections include a 1/4” Mounting Hole, 3/8” Mounting Hole, Camera Control Port, Accessory Port, USB-C Port, and an RSA Port. Users will be able to connect wirelessly with the machine using Bluetooth 5.0, with an app for iOS or Android. The iOS app requires iOS 9 or above, and Android requires Android version 5 or above. Tested payload for this gimbal is under 2kg – that’s under 4.4 pounds. So don’t go attaching a big sack full of mercury or anything strange – that won’t work. Angular vibration range is ±0.02°, and maximum controlled rotation speed is 180°/s for pan, tilt, and roll axis control.
Connected home appliances and smart devices are getting more and more common these days but not everyone may be confident in setting those up. Their added complexity means that you can no longer just plug an appliance or screw a bulb and just expect it to work. Sometimes, on-site, or in-home rather, installation and training are even needed to take full advantage of these new technologies and DISH’s new OnTech Smart Services is more than ready to provide exactly that. Connected appliances are pretty smart but not smart enough to set themselves up. At the very least, users have to connect them to the home network using the app designed for that product or brand. The number of competing brands means there’s quite a confusing mix of apps and platforms, some of which don’t even speak a single language.That’s where the OnTech Smart Services by DISH comes in. The new service’s technicians go to homes to do the installations for customers. That’s especially helpful for more complicated products like video doorbells and thermostats. They can even make finishing touches like TV mounting or power relocation.Going beyond the initial setup, OnTech personnel can also do one-on-one education to teach owners how to use the products. Many new smart home owners might not be aware of the full range of capabilities their new toys have and some don’t have the time to dig through all the menus and options available.OnTech Smart Services support products Google Nest, Ring, Linksys, Wemo, Roku®, Yale, Polk Audio, and Klipsch Audio. At the moment, it’s a limited rollout in a few markets in the US, including Atlanta, New York, Dallas/Ft. Worth, Sacramento, Denver, Salt Lake City, Houston, San Francisco, Kansas City, St. Louis, and Los Angeles.
More than 1,100 Georgia pediatricians have joined a new physician-led network that aims to improve quality of care and eventually contract for payments from insurers. The sign-ups represent roughly one-third of the pediatricians practicing in the state. Children’s Healthcare of Atlanta, the major pediatric hospital system in the metro area, helped create the nonprofit entity, called the Children’s Care Network. (MIller, 9/1) Health News Florida: State In Legal Battle Over Prescription Drug Benefits The San Jose Mercury News: Santa Clara County To Sever $300 Million Contract Over Valley Med Hospital Upgrade The governors of all six New England states have sent a letter urging the head of the U.S. Food and Drug Administration to tighten warnings on opioids.The governors said the FDA should require changes on labels for immediate release opioids to make sure patients and doctors understand the risk of addiction, overdose, neonatal abstinence syndrome and death associated with the drugs. (8/31) The Associated Press: New England Governors Urge FDA To Set Tougher Opioid Labels Pharmacy-benefit managers for the state-employee health insurance program are challenging an attempt to require them to repay $39.2 million to the Florida Department of Management Services. Medco Health Solutions, Inc. and Express Scripts, Inc., which are subsidiaries of the same holding company, have filed a series of legal petitions that were sent this month to the state Division of Administrative Hearings. (8/31) The service at issue, known as extended, or complex, nursing care, involves a nurse providing services in a person’s home for more than two hours at a time. Clients must have their services reauthorized periodically to continue receiving them. Data from the state Department of Social Services shows the denial rate for requests for extended nursing services has risen sharply since the beginning of the year. (Levin Becker, 9/1) This is part of the KHN Morning Briefing, a summary of health policy coverage from major news organizations. Sign up for an email subscription. Santa Clara County’s $300 million expansion and seismic upgrade at Valley Medical Center is already two years behind schedule — with no hope of opening next month in time for its latest deadline. Now, in an increasingly bitter dispute that played out Monday at the construction site, the county declared it intends to fire Turner Construction, the company overseeing the project and one of the country’s biggest builders, whom county officials blame for falling woefully behind on the job. (De Sa, 8/31) Kaiser Health News: A Third Of Ga. Pediatricians Join Together To Form Network To Improve Care Dr. David Burkons graduated from medical school and began practicing obstetrics and gynecology in 1973 – the same year of the Supreme Court’s landmark abortion decision in Roe v. Wade. Burkons liked delivering babies but he is also committed to serving his patients, including those who choose abortions. (Tribble, 8/31) State Highlights: Fla. Embroiled In Legal Fracas Over Prescription Drug Benefits; New England Governors Urge FDA To Toughen Opioid Warnings Health care stories are reported from Florida, Connecticut, California, Ohio and Georgia. Kaiser Health News: In Ohio, New Abortion Clinic Opens, Bucking National Trend The Connecticut Mirror: Uptick In Denials For Home Nursing Care Worries Families, Advocates
This is part of the KHN Morning Briefing, a summary of health policy coverage from major news organizations. Sign up for an email subscription. The Associated Press: High Court Skeptical Of State Power To Gather Health Data The Wall Street Journal: Vermont’s Effort To Gather Data On Health-Care Costs Faces Supreme Court Test Vermont’s Green Mountain Care Board requires insurers to provide information on payments made to medical providers, hoping that by knowing what is paid for health care it can find ways to keep costs in check and improve efficiency and quality of care. At least 18 other states already have or are setting up similar databases, but Vermont has the boldest experiment in mind: eventually building a single-payer plan that would aim for universal coverage akin to programs in Canada and some European countries. … Vermont’s solicitor general, Bridget Asay, told the Supreme Court on Wednesday that Congress intended to encourage states to collect data that could provide insight into improving care or reducing expenses. She said the 2010 Affordable Care Act, which amended the 1974 law, “contemplated a robust federal-state partnership in health experimentation.” (Bravin and Radnofsky, 12/2) Some legislators and policymakers consider the databases important tools to improve care and reduce costs. (Gorn, 12/2) Reuters: U.S. Justices Cast Doubt On Scope Of Vermont Healthcare Data Law California Healthline: Supreme Court To Hear Case Deciding Fate of All-Payers Claims Databases Members of the U.S. Supreme Court on Wednesday indicated that Vermont and 17 other states could be prevented from collecting healthcare information from certain employee health plan administrators. The nine justices heard a one-hour oral argument over whether a 2005 Vermont data collection law aimed at improving the quality of healthcare applies to self-funded insurance plans, which are most commonly used by large companies. (12/2) High Court Hears Oral Arguments On Vermont Health Care Data Law Some of the state insurers argued that federal law bars states from requiring insurers to supply data on the costs and outcomes of their services. But some policymakers counter that these databases are important in the effort to improve quality of care and control costs. The Supreme Court on Wednesday appeared skeptical that state officials have the power to require health insurers to turn over reams of data revealing how much they pay for medical claims. Most of the justices seemed to agree during a one-hour argument that efforts by Vermont and other states to collect and publicize the data conflict with federal law governing certain health plans. (Hananel, 12/2)
Stat: The Hospital Exec On New Generic Maker: Trying To Bring ‘Sanity’ Stat: Fact-Checking An Ad War Over Drug Prices, Celgene, And Bob Hugin Stat: SEC Charges Biotech Billionaire Philip Frost With Pump-And-Dump Fraud The Wall Street Journal: General Atlantic Takes Majority Stake In OneOncology, A Startup For Running Cancer-Doctor Practices Kaiser Health News: Unwitting Patients, Copycat Comments Play Hidden Role In Federal Rule-Making The rising cost of prescription drugs is an issue in midterm races across the country, but nowhere more so than in New Jersey, where one candidate is the recently retired CEO of an actual drug company. So we decided to take a look at the rhetoric in that race, pitting incumbent Sen. Bob Menendez against former Celgene boss Bob Hugin. In TV ads blanketing New Jersey (and Philadelphia and New York City), Menendez paints his opponent as a craven profiteer, raising prices on patients with no other options. But Hugin argues that Celgene has saved thousands of lives by giving away doses of its banner cancer drug for free to patients who can’t afford it. (Garde, 9/11) Stat: Pfizer Taps Two Neuroscience Startups For Incubator Prize Just months after Pfizer slashed hundreds of jobs in its own neuroscience R&D program, the pharmaceutical giant is making notable investments in two Boston-based neuroscience startups. The company announced Wednesday that Tevard Biosciences and QurAlis will each receive one of Pfizer’s coveted “Golden Tickets”— a valuable voucher for the fees associated with renting a spot for one scientist for one year at LabCentral, a biotech incubator in Cambridge, Mass. For companies based elsewhere, the ticket also allows a start-up to set up shop at the noted space in Kendall Square. (Sheridan, 9/12) How PBMs Can End Up Pocketing Nearly $200 For A Bottle Of Pills Costing Less Than $6 News outlets report on stories related to pharmaceutical pricing. The New York Times: A Battle Plan For A War On Rare Diseases Boston Globe: In The Go-Go Biotech World, A Cautionary Tale Stat: Amid Anger Over Drug Prices, Former Pharma CEO Bob Hugin Runs For The Senate Bloomberg: The Secret Drug Pricing System Middlemen Use To Rake In Millions Private-equity firm General Atlantic has agreed to invest $200 million in a startup that aims to manage independent cancer-treatment clinics, the latest sign investors see opportunity in the health-services sector. The investment makes General Atlantic the majority owner of OneOncology, a startup that launched this month. Its founders, three cancer-treatment practices in Tennessee and New York, are the other owners and its first customers. (Evans, 9/12) File this under “If at first you don’t succeed, …” AmerisourceBergen (ABC), which is one of the nation’s largest pharmaceutical wholesalers, has conceded that its compounding business needs to be fixed, so the company has hired manufacturing experts to review procedures at a key facility in Memphis and postponed plans to resume shipments. (Silverman, 9/7) Not everybody reads the legal notices inside the Ottumwa Courier. But in January, Iowa pharmacist Mark Frahm noticed something unusual in the paper. For years, Frahm’s South Side Drug bought pills from distributors, and dispensed prescriptions to the Wapello County jail. In turn, the pharmacy got reimbursed for the drugs by CVS Health Corp., which managed the county’s drug benefits plan. As he compared the newspaper notice with his own records, and then with the county’s, Frahm saw that for a bottle of generic antipsychotic pills, CVS had billed Wapello County $198.22. But South Side Drug was reimbursed just $5.73. So why was CVS charging almost $200 for a bottle of pills that it told the pharmacy was worth less than $6? And what was the company doing with the other $192.49? (Langreth, Ingold and Gu, 9/11) The Wall Street Journal: Big Pharma Catches Up With Biotech For the CEO of a biotech startup, there may be no bigger asset than a compelling sales pitch. Frank Reynolds had a great one. He hadn’t planned a career in biotechnology, the head of Cambridge-based InVivo Therapeutics would tell investors. His calling found him. (Saltzman, 9/8) The Wall Street Journal: Drug Distributor AmerisourceBergen Names New Finance Chief Angered by rising prices and persistent shortages of generic drugs, seven of the nation’s largest hospital systems have launched a new, not-for-profit manufacturer. The company, which was first discussed publicly earlier this year, starts with a $100 million in capital and loans, some of which will come from three philanthropic organizations, including the Laura and John Arnold Foundation. Civica Rx will contract with other companies to make more than a dozen generics and some sales will start in mid-2019. We spoke with Dan Liljenquist, a vice president at Intermountain Healthcare who initiated the project, about the possibilities and challenges. This is an edited version of our conversation. (Silverman, 9/6) Stat: AmerisourceBergen Scrambles Again To Fix A Troubled Compounding Facility Among the 30,000 attendees of the Rutherford Street Fair, sweating it out on the street between the zeppoles and deep-fried Oreos, was the pharmaceutical millionaire who wants to be their next senator. Bob Hugin, the former CEO of Celgene, spent Labor Day walking through the crowd with a phalanx of staff and volunteers, each with a sign and a T-shirt bearing his name. They chanted, cheered, and sloganeered as Hugin’s would-be constituents looked on, varyingly bemused or befuddled at the merry little militia demonstrating in their town. Hugin shook hands, posed for photos, and remembered to say “good to see you” but never “nice to meet you.” (Garde, 9/6) A proposal to sharply cut a drug discount program that many hospitals rely on drew some 1,400 comments when the Trump administration announced its plan last year. Hundreds appeared to come from patients across the country — pleas from average Americans whose treatments for diseases such as cancer depend on costly medicines. But a review of the responses found that some individuals were not aware they apparently had become part of an organized campaign to oppose what’s known as the “340B” program. (Tribble, 9/11) It was a great summer for big pharma stocks. Investors shouldn’t expect that trend to reverse this fall. As has become routine, biotechnology stocks had a strong summer. A broad index of those stocks is up about 15% this year and is near a record. This time, however, major pharmaceutical companies are joining in the rally. (Grant, 9/5) A decade ago, when their son Bertrand was still an infant, Matthew Might and his wife, Cristina, realized that there was something terribly wrong. When he cried, his eyes stayed dry; the lack of tears damaged his corneas and threatened blindness. Eventually, he suffered seizures, a movement disorder and a severe developmental delay. It took four years to discover the problem: Bertrand had inherited two mutations of the NGLY1 gene, which plays a key role in recycling cellular waste. That meant the child’s cells were choking on their own trash. (Weintraub, 9/10) This is part of the KHN Morning Briefing, a summary of health policy coverage from major news organizations. Sign up for an email subscription. Philip Frost, a longtime biotech billionaire, was accused Friday of taking part in a pump-and-dump stock scheme that bilked investors out of $27 million. The Securities and Exchange Commission charged Frost and nine others in connection with what it described as a scheme to buy up shares in penny-stock biotechs, illegally promote the companies online, and then sell their shares before the bottom fell out. (Garde, 9/7) Drug distributor AmerisourceBergen Corp. ABC -0.35% said its finance chief Tim Guttman will retire in November and will be succeeded by Executive Vice President James Cleary. Mr. Guttman has served as the company’s chief financial officer since May 2012, and was previously vice president and corporate controller since joining the company in 2002. He will continue to serve as an adviser further into fiscal 2019 to ensure a smooth transition, the company said. (Shumsky, 9/10)
Recommended For YouOman urges Iran to release seized tankerDavid Rosenberg: Deflation is still the No. 1 threat to global economic stability — and central banks know itTrans Mountain construction work can go ahead as National Energy Board re-validates permitsBank of Canada drops mortgage stress test rate for first time since 2016The storm is coming and investors need a financial ark to see them through The Canadian Press Metro hikes dividend, reports sales up from year ago Adjusted profit up More Join the conversation → Featured Stories Sponsored By: Reddit Email MONTREAL — Metro Inc. raised its dividend as it reported a first-quarter profit of $203.1 million.The grocery and drug store company says it will pay a quarterly dividend of 20 cents per share, up from 18 cents per share.Metro reported its profit amounted to 79 cents per diluted share for the 12 weeks ended Dec. 22, compared with a profit of nearly $1.3 billion or $5.67 per diluted share for the same period a year earlier.At that time, it benefited from the sale of its stake in Alimentation Couche-Tard Inc. to help fund its deal to buy the Jean Coutu Group Inc.On an adjusted basis, Metro says it earned $172.2 million or 67 cents per diluted share for its latest quarter, up from an adjusted profit of $126.7 million or 55 cents per diluted share a year earlier.Analysts on average had expected a profit of 68 cents per share for the quarter, according to Thomson Reuters Eikon.Sales for what was the company’s first quarter totalled $3.98 billion, up from $3.11 billion a year earlier. What you need to know about passing the family cottage to the next generation ← Previous Next → Metro Inc. raised its dividend as it reported a first-quarter profit of $203.1 million.Canadian Press/Paul Chiasson / THE CANADIAN PRESS 0 Comments advertisement Facebook Twitter Share this storyMetro hikes dividend, reports sales up from year ago Tumblr Pinterest Google+ LinkedIn January 29, 20199:32 AM EST Filed under News Retail & Marketing Comment
Chevy Bolt, Baojun E100 Push GM Global Plug-In Sales Ahead Of U.S. Author Liberty Access TechnologiesPosted on September 12, 2018Categories Electric Vehicle News Electrified transmissions? Let’s have a look at what this General Motors executive is talking about.So much uncertainty in the future of OEMs’ electrification plans is forever present. Thus, Autoline’s John McElroy interviews General Motors’ top dog for global transmission electrification, to get a better idea of what’s in store.Check Out These Stories: Executive Director of Global Transmission Electrification at GM, Mike Anderson titled his recent share “Navigating the Uncertainty.” While this may come across as pro- or anti-electric vehicles, one can certainly understand the dilemma. As electrification slowly unfolds and eventually becomes the norm, how can OEMs bank on the tried-and-true practices, all while preparing for the imminent future? From an EV aficionado perspective, legacy automakers aren’t doing enough. But in reality, people like Anderson seem to be aware of and on top of it.Anderson realizes that flexibility is paramount and having the team ready is key. Now, it’s all a matter of the “if” and “when.” While we’d love to say that legacy automakers aren’t planning or doing enough, it all comes with the territory.He reveals that even with an ICE or hybrid car today, electrified transmissions are already key. When it comes to transmissions for electric cars, next-gen transmission development is already on par and ready to go. Anderson admits that GM is already in “Lane 2” in terms of the development of this tech. He assures that for some EVs that are performance capable, a two-speed transmission makes sense.GM is taking notes and has been for years in regards to its Chevrolet Volt and Bolt EV. Anderson admits that while some of the data was expected, the automaker has learned quite a bit along the way. Check out the video above for more information.Video Description via Autoline Network on YouTube:GM: Navigating the Uncertainty – CAR MBS 2018Automakers have been adding more and more gears to transmissions over the years. But that trend won’t last, according to Mike Anderson, the Executive Director of Global Transmission Electrification at GM. With the move to EVs, he says were about to see more electrified transmissions in our vehicles. GM: “At least” 20 New EVs To Debut In Next 5 Years, Two in Next 18 Months GM CEO Barra Acknowledges Tesla’s “Very Capable” Cars Source: Electric Vehicle News
Source: Amada Miyachi Europe Manufacturing batteries for EVs requires specialized equipment, and battery makers require different systems depending on battery type, tab material and thickness, and production volume. Amada Miyachi Europe is a company that provides a range of resistance and laser welding equipment for just this purpose.Most recently, the company provided resistance welding equipment to German battery system manufacturer LION Smart for the development of a proprietary new battery. LION Smart’s LIGHT Battery provides 100 kWh of energy, and keeps the cells cool by immersing them in 3M Novec cooling fluid.The LIGHT Battery was designed for fully automated production. It uses infrared communication instead of wires, which frees up the cylindrical cells for a high packing density.Amada Miyachi Europe provides six laser welding technologies and four resistance welding technologies, as well as micro-arc (or pulse-arc) welding. Source: Electric Vehicles Magazine
Because something is happening here, but you don’t know what it is.Source: Electric Vehicle News
Share on Twitter Share on Messenger Share on Facebook Topics Shares00 Horse racing Share on Twitter Share via Email First published on Tue 19 Aug 2008 19.01 EDT Following a series of near-misses at the highest level, Raven’s Pass is 5-4 favourite with bookmakers Blue Square to gain a deserved victory in the Group Two Celebration Mile at Goodwood on Saturday. John Gosden’s colt, beaten just a head by Henrythenavigator in the Sussex Stakes last month, could be opposed by last weekend’s impressive Hungerford Stakes winner, Paco Boy. Richard Hannon’s three-year-old is 3-1, with Bankable on offer at 9-2.The Prix Morny is the next feature race in Deauville’s run of Group One events on Sunday and the prestigious two-year-old prize will again be a target for British and Irish trainers, who between them have won the last three renewals. Since you’re here… Raven’s gets another chance at Goodwood Peter Chapple-Hyam, successful with Dutch Art two years ago, plans to run Sayif, who is reported in “good order”. Sayif has yet to win a race but has twice been placed in Group Two company. Prolific, winner of the Richmond Stakes last time, holds an entry in the Morny but is unlikely to figure after today’s first forfeit stage. “It will almost certainly be too soft for him in France,” said Harry Herbert, who manages the Highclere Thoroughbred syndicate, owners of Prolific. Prolific had already been scratched from York’s Gimcrack Stakes before the weather intervened. “He is a top-of-the-ground horse and we will wait for the Mill Reef Stakes at Newbury with him,” said Herbert. “His principal target is the Middle Park. He’s progressing physically and is a gutsy trier.” Irish trainer David Wachman is also considering the Morny for his Bushranger following the colt’s fine effort in defeat at The Curragh last month. York is not the only racetrack to be hit by the recent wet weather. Today’s meeting at Carlisle has also been lost, while there is a 7am inspection to determine if racing can go ahead at Hamilton. Share on Facebook Read more Ron Cox Support The Guardian Share via Email Tue 19 Aug 2008 19.01 EDT Share on Pinterest … we have a small favour to ask. The Guardian will engage with the most critical issues of our time – from the escalating climate catastrophe to widespread inequality to the influence of big tech on our lives. At a time when factual information is a necessity, we believe that each of us, around the world, deserves access to accurate reporting with integrity at its heart.More people are reading and supporting The Guardian’s independent, investigative journalism than ever before. And unlike many news organisations, we have chosen an approach that allows us to keep our journalism accessible to all, regardless of where they live or what they can afford. But we need your ongoing support to keep working as we do.Our editorial independence means we set our own agenda and voice our own opinions. Guardian journalism is free from commercial and political bias and not influenced by billionaire owners or shareholders. This means we can give a voice to those less heard, explore where others turn away, and rigorously challenge those in power.We need your support to keep delivering quality journalism, to maintain our openness and to protect our precious independence. Every reader contribution, big or small, is so valuable. Support The Guardian from as little as $1 – and it only takes a minute. Thank you. Share on LinkedIn The Recap: sign up for the best of the Guardian’s sport coverage Horse racing Share on WhatsApp Reuse this content
This previous post highlighted facts and figures from SEC enforcement of the FCPA in 2015.This post highlights facts and figures from corporate DOJ FCPA enforcement in 2015. (See here for a similar post from 2014, here for a similar post from 2013, here for a similar post from 2012, here for a similar post from 2011, and here from 2010).When reviewing the statistics below, keep in mind that there were only 2 corporate FCPA enforcement actions in 2015. Thus, certain of the below statistics are largely meaningless, yet nevertheless highlighted for comparative purposes.Settlement Amounts and SpecificsIn 2015, the DOJ brought 2 corporate FCPA enforcement actions (the lowest number of corporate DOJ FCPA enforcement actions since 2006).By comparison, in 2014, the DOJ brought 7 corporate FCPA enforcement actions; in 2013 the DOJ brought 7 corporate enforcement action; in 2012 the DOJ brought 9 corporate FCPA enforcement actions; in 2011 the DOJ brought 11 corporate enforcement actions; and in 2010 the DOJ brought 17 corporate enforcement actions. (Note: these figures use the “core” approach to FCPA statistics – see here for the prior post – an approach also endorsed by the DOJ – see here).In the 2 corporate FCPA enforcement actions from 2014, the DOJ collected approximately $24.2 million in criminal fines.By comparison, in the 7 corporate FCPA enforcement actions from 2014, the DOJ collected approximately $1.25 billion in criminal fines (an all-time record in terms of yearly FCPA settlement amounts); in the 7 corporate FCPA enforcement actions from 2013, the DOJ collected approximately $420 million in criminal fines; in 2012, the DOJ collected approximately $142 million in criminal fines; in 2011, the DOJ collected approximately $355 million in criminal fines ($504 million including the $149 million forfeiture in the Jeffrey Tesler individual enforcement action); and in 2010, the DOJ collected approximately $870 million in criminal fines.Corporate DOJ FCPA enforcement in 2015 ranged from $17.1 million (Louis Berger) to $7.1 million (IAP Worldwide). Both enforcement actions were DOJ only and involved privately-held companies.In the 1 corporate FCPA enforcement actions where an analysis was possible, the DOJ agreed to a criminal fine at the minimum range suggested by the sentencing guidelines.[Note – the IAP Worldwide enforcement action was resolved via an NPA and the DOJ does not set forth a guidelines range in NPAs]Corporate vs. Individual ProsecutionsOf the 2 corporate DOJ enforcement actions in 2015, 2 (100%) resulted in related DOJ prosecutions of company employees. Notwithstanding this 2015 statistic, as highlighted in this prior post, approximately 75% of DOJ corporate enforcement actions since 2008 have not (at least yet) resulted in any DOJ charges against company employees.The DOJ announced 8 individual FCPA enforcement actions in 2015 (Harder, Rama, Hirsch/McClung, Garcia, Condrey and Rincon / Shiera) in 6 core actions.Stay tuned for future posts specifically about DOJ and SEC individual FCPA enforcement actions in 2015.NPAs / DPAsIn 2015, 2 of the 2 (100%) DOJ corporate enforcement actions were resolved via an NPA (IAP Worldwide) or a DPA (Louis Berger).By way of comparison, in 2014, 5 of the 7 (71%) DOJ corporate enforcement actions included an NPA or DPA; in 2013, 100% of corporate DOJ enforcement actions involved either an NPA or DPA; in 2012 100% of corporate DOJ enforcement actions involved either an NPA or a DPA; in 2011 82% of corporate DOJ enforcement actions involved either an NPA or DPA; and in 2010 94% of corporate DOJ enforcement actions involved either an NPA or DPA.Since 2010, approximately 85% of corporate DOJ enforcement actions have involved either an NPA or DPA.Voluntary DisclosuresOf the 2 DOJ corporate enforcement actions in 2015, 1 enforcement action (50%) was the result of a corporate voluntary disclosure.[Note – the Louis Berger DPA states as follows: “after the government had made [the company] … aware of a False Claim Act investigation, [the company] conducted an internal investigation, discovered potential FCPA violations, and voluntarily self-reported to the [DOJ] the misconduct.” The origin of the IAP Worldwide action is unclear as the NPA makes no mention of voluntary disclosure or other potential origins of the action.]By way of comparison, of the 7 corporate DOJ FCPA enforcement actions in 2014, 2 enforcement actions (29%) were the result of corporate voluntary disclosures; in 2013 57% of corporate FCPA enforcement actions were the result of corporate voluntary disclosures or the direct result of a related voluntary disclosure; in 2012, 78% of corporate FCPA enforcement actions were the result of corporate voluntary disclosures or casually related to previous corporate voluntary disclosures; in 2011, 73% of corporate FCPA enforcement actions were the result of corporate voluntary disclosures.MonitorsOf the 2 corporate DOJ FCPA enforcement actions in 2015, 1 (50%) enforcement action (Louis Berger) resulted in a corporate monitor.By way of comparison, of the 7 corporate DOJ FCPA enforcement actions in 2014, 1 (14%) resulted in a corporate monitor; of the 7 corporate DOJ FCPA enforcement actions in 2013, 4 enforcement actions (57%) involved a monitor; of the 9 corporate DOJ FCPA enforcement actions in 2012, 3 enforcement actions (33%) involved a monitor; of the 11 corporate DOJ FCPA enforcement actions in 2011, 1 enforcement action (9%) involved a corporate monitor; of the 17 corporate DOJ enforcement actions in 2010, 7 enforcement actions (41%) involved a corporate monitor.This remainder of this post provides an overview of corporate DOJ FCPA enforcement in 2015.*****Louis Berger Int’l. (July 17th)See here for the prior postCharges: Conspiracy to violate the FCPA’s anti-bribery provisionsResolution Vehicle: DPAGuidelines Range: $17.1 million – $34.2 millionPenalty: $17.1 million.Disclosure: The DPA states: “after the government had made [the company] … aware of a False Claim Act investigation, [the company] conducted an internal investigation, discovered potential FCPA violations, and voluntarily self-reported to the [DOJ] the misconduct”Monitor: YesIndividuals Charged: YesIAP Worldwide Services Inc. (June 16th)See here for the prior postCharges: Not applicable.Resolution Vehicle: NPAGuidelines Range: None set forth in the NPA.Penalty: $7.1 million.Disclosure: Unclear, the NPA makes no mention of voluntary disclosure or other potential origins of the action.Monitor: NoIndividuals Charged: Yes
Source:http://americanpainsociety.org/220-pain-rehab-programs-without-opioids-proving-effective Jun 27 2018American Pain Society Study Reports Significant Quality of Life Improvements New research, published this month by the American Pain Society (APS), adds to burgeoning scientific evidence showing that interdisciplinary pain rehabilitation programs are an effective alternative to opioids for chronic pain management. Despite several studies documenting favorable outcomes, access to multi-modal pain management programs remains out of reach for most patients due to inadequate insurance coverage. This discourages providers from opening new interdisciplinary pain clinics.”Doctors refer patients to specialty pain clinics, usually filled to capacity, so desperation sets in and the next stop could be a dealer on the street,” said William Maixner, DDS, PhD, president of the American Pain Society. “We need more specialty pain clinics, but paltry reimbursements offer no incentives for opening more programs.”Related StoriesAre Chronic Pain Relief Drugs for Children Effective?Family members’ drugs may be risk factor for overdose in individuals without prescriptionsBirth, child outcomes linked with maternal opioid use during pregnancyThe new study appears in the June issue of The Journal of Pain, the APS peer-review publication. Researchers from Mayo Clinic hypothesized that patients with chronic pain not using opioids and those tapered off opioids during treatment would experience significant improvements in self-report and performance-based functional outcomes from treatments in interdisciplinary pain rehabilitation programs (IPRPs).Results showed that patients who were tapered off opioids showed improvement comparable to patients not taking opioids and experienced sustained improvements in functioning six months after treatment. The authors concluded their findings suggest that regardless of previous opioid use status, IPRP treatment leads to sustained functional restoration for chronic pain for an enhanced degree of daily functioning.”The ultimate aim of IPRP is not to alleviate pain or produce short-term functional gains, but rather to foster sustained benefits that patients can continue for the remainder of their lives,” the authors wrote.”Biopsychosocial approaches to pain assessment can enhance treatment outcomes by better matching patients to appropriate therapies. More and more studies are showing that psychosocial pain treatments work and are making a difference,” Maixner said. “Medicare, Medicaid and private insurers, therefore, must offer better coverage for biopsychosocial pain management as part of a comprehensive national effort to bring relief to people with chronic pain without resorting to opioids.”
Source:https://www.iospress.nl/ios_news/early-treatment-with-nusinersen-can-mean-better-outcomes-for-babies-with-spinal-muscular-atrophy/ Jul 17 2018Spinal muscular atrophy (SMA) is a genetic disease that affects motor neurons in the spinal cord, resulting in muscle atrophy and widespread weakness that eventually impair swallowing and breathing. A new study in the Journal of Neuromuscular Diseases finds that children with SMA type 1 can achieve improvements in motor function after six months of treatment with the drug nusinersen, particularly when treatment began before seven months of age. These findings highlight the importance of early detection of SMA through newborn screening.”Our findings add to the increasing body of evidence that early diagnosis and initiation of treatment is fundamental for patients with infantile-onset spinal muscular atropy,” explained lead investigator Janbernd Kirschner, MD, of the Department of Neuropediatrics and Muscle Disorders, Medical Center, Faculty of Medicine, University of Freiburg, and Coordinator of the TREAT-NMD Clinical Trial Coordination Centre (CTCC), Freiburg (Germany).SMA type 1 is the most common and also most severe subtype of SMA. After diagnosis infants with SMA type 1 rarely achieve improvements of motor function or attain motor developmental milestones. Within the last few years, there has been a promising approach for the development of novel drugs intervening the pathophysiology of SMA. Among these, nusinersen is the first drug specifically approved to treat SMA. Prior to approval in Europe, nusinersen was provided to patients with SMA type 1 within an Expanded Access Program (EAP). In contrast to the previous clinical trials, children of different age groups and different stages of the disease were treated with nusinersen within the EAP.The current prospective, open-label study conducted in Germany reports outcomes from 61 children with SMA type 1 treated with nusinersen between November 2016 and June 2017 who met EAP guidelines. Patients ranged in age from a few months to almost 8 years. Symptoms generally appeared within the first three months of life and most babies were diagnosed before six months of age. Prior to treatment, more than jhalf of the children required ventilation support, 20% had already undergone a tracheostomy, and more than half required a feeding tube.Related StoriesChaos in the house and asthma in children – the connectionGenetic contribution to distractibility helps explain procrastinationWhy Mattresses Could be a Health Threat to Sleeping ChildrenAlthough improvements in motor function are not expected within the natural course of the disease, the researchers observed improvements in motor function after six months of nusineresen therapy in many patients, and 34% of the patients achieved new motor developmental milestones. The response to treatment strongly correlated with age at onset of treatment. Overall, greater improvements were seen in children who began treatment at seven months or younger compared to those who started treatment after seven months. Improvements could still be seen in patients who started therapy between two and four years of age, although the magnitude of the changes was less than those for infants. Despite six months of treatment, none of the children were able to stand or walk independently, and many still required ventilator support and tube feeding.The findings of this study add to the increasing body of evidence that early diagnosis and initiation of treatment are fundamental for patients with infantile onset spinal muscular atrophy highlighting the importance of the implementation of a newborn screening. “We have evidence that there is a critical therapeutic time window for delivery of SMN-targeted therapies,” noted Dr. Kirschner. “The implementation of newborn screening for SMA is crucial to allow pre-symptomatic diagnosis.Based on the results of this study, the SMArtCARE project aims to collect further data of all SMA patients to evaluate outcomes in a broader spectrum of SMA, the effect of treatment after prolonged treatment periods, and also to what extent changes in motor function affect patients’ and caregivers’ quality of life.SMA is caused by mutations in the survival motor neuron (SMN) 1 gene, which codes for survival motor neuron protein. This leads to loss of function. The SMN 1 gene is located on chromosome 5q13. Nusinersen, the first drug to be approved for SMA, is an antisense oligonucloetide which leads to increased expression of more full-length and functional SMN protein by functionally converting the SMN2 gene into the SMN1 gene. Nusinersen is injected into the spinal canal to allow it to distribute to the central nervous system.
Jul 18 2018Settling youngsters down to sleep at night isn’t always easy. Recent research suggests that the amount of exposure children have to bright light in the hour leading up to bedtime -; whether emanating from light bulbs or electronic devices -; can have a big impact on sleep-related behavior.There’s chemistry behind it. Our circadian rhythm -; a kind of 24-hour internal brain clock that cycles regularly between sleepiness and alertness -; employs melatonin, the body’s natural sleep-inducing hormone. Melatonin is highly sensitive to light. As daylight dims toward the end of the day, our bodies are programmed to react to the reduction of light by increasing the production of melatonin. It’s nature’s way of ushering us toward sleep. Artificial light, however, can disrupt the circadian cycle by inhibiting the production of melatonin.Related StoriesDynamic Light Scattering measurements in concentrated solutionsMore than 936 million people have sleep apnea, ResMed-led analysis revealsSleep makes synapses ready for new learningResearch into the effects of light on preschool-age children found that youngsters are particularly sensitive to light exposure in the hour prior to bedtime. (Children’s clear crystalline eye lens and large pupil size render them generally more sensitive to light than adults.) According to some researchers, evening light exposure, with its melatonin-suppressing effect, may increase the likelihood of sleep disturbances in preschool-age children. When little ones shuffle out of a dark or dimly lit bedroom to tell parents “I’m thirsty” or “I heard a strange noise,” the bright light they encounter has been found to reduce their melatonin production, making it all that much harder for them to fall asleep when back in bed. Even reading bedtime stories in a brightly lit room can make it harder to fall asleep at story’s end. Dimming the ambient light, in both the child’s room and whatever spaces they might walk into, maybe a wise approach whenever possible.Mobile electronic devices, with their bright white screens, pose a similar risk. As many as 90% of preschool-age youngsters use devices, often during the hour before bedtime. But it’s not only preschoolers; youngsters of all ages find themselves glued to screens as the very last activity of their day. Studies found that following light exposure, melatonin remains suppressed for nearly an hour after the lights go off -; time for tossing and turning and missing out on essential shut-eye. Parents might declare the last hour prior to bedtime a device-free period, or insist that youngsters slide the brightness setting way down on their handheld electronics.Source: https://www.family-institute.org/
Aug 13 2018The use of benzodiazepines and related drugs (Z drugs) is associated with a modestly increased risk of Alzheimer’s disease, according to a recent study from the University of Eastern Finland. The risk increase was similar with both benzodiazepines and Z drugs regardless of their half-life. The results were published in Acta Psychiatrica Scandinavica.Related StoriesResearchers identify brain somatic mutations linked to Alzheimer’s diseaseArtificial DNA can help release active ingredients from drugs in sequence$4.23 million NIH grant to support development of Cleveland Alzheimer’s Disease Research CenterEven though the increased risk for Alzheimer’s disease was small in this study, the threshold for prescribing benzodiazepines and related drugs should be high enough due to their several adverse effects and events, such as falls. These medications are commonly used for sleep problems, but their effectiveness for this indication diminishes over weeks or months. However, the risk of adverse events remains in longer-term use.The study was conducted in the nationwide MEDALZ cohort which included all Finnish community dwellers with newly diagnosed Alzheimer’s disease in 2005-2011 (70,719 persons), and their age, sex and region of residence matched controls (282,862 persons). Medicine use since 1995 was extracted from the Finnish Prescription Register. Many chronic disorders, substance abuse, socioeconomical position and use of antidepressants and antipsychotics were taken into account. To account for reverse causality, drug use within 5 years before Alzheimer’s disease diagnosis was not taken into account. Source:http://www.uef.fi/-/bentsodiatsepiinien-kaytto-on-yhteydessa-kohonneeseen-alzheimerin-taudin-riskiin
ShareTweetSharePinDr. Worrel Sanford is the UWP candidate for the Kalinago ConstituencyUnited Workers Party (UWP) candidate for the Salybia constituency, Dermatologist, Dr. Worrel Sanford has stated that he is deeply appalled and worried by what he says is the blatant disrespect shown by the Ministry of Kalinago Affairs, the Ministry of Health and the government with regard to a human resource development activity which was recently undertaken in the Kalinago Territory.Dr Sanford has accused the named authorities of snubbing and undermining “the effort of one of their inspiring Kalinago women in taking the lead to contribute to the development of the human resource capital of the communities and more so, the empowering of Kalinago women.”One of the graduates receives a trophySanford explained in a release that Anette Thomas-Sanford, a nurse by profession, recognizing the need for trained health care providers and the inability of the state mechanism to respond in a timely manner, conceptualized a health-care providers training programme with the input of the then Dean of Health Sciences at the Dominica State College (DSC), Denise Edwards. The course was offered in the Kalinago Territory.“Despite several attempts to engage the Ministry of Health and Kalinago Affairs, they made absolutely no effort to get involved, to advice, support or to endorse the programme,” Sanford stated. “Not even the Salybia Health Center; the state did not spend one cent in constructing, did they want to make available for the six (6) month programme.”He continued, “Thanks to the Kalinago Chief for his tenacity! At the end, 18 young women graduated from the programme despite the calculated barriers set by the very same people who profess on political platforms and selected forums that they are pro-women independence and people empowerment and no one loves the Kalinago people more than they do.”Sanford contends that one is left with no choice but to “discard in the trash bins, the pronouncements made by some of us in leadership positions as it relates to the socio-economic development of our people and in particular our indigenous Kalinago women.” He said as a medical professional, he fully endorsed “this outstanding initiative” by Nurse Thomas-Sanford and vowed, under a UWP led government, to explore all possible avenues for the further development of this programme, given its dire need.“The double standard, snubbing and politicizing of all good efforts by our people cannot continue to go unabated if we truly want to see a better society tomorrow,” he remarked. “Such calculated actions are tantamount to building walls and not bridges.”Sanford insists that the Ministry of Kalinago Affairs must be and will be run as a state entity which facilitates the development of the Kalinago people not as a DLP outpost, “with a sole mandate to thwart the progress of our communities by keeping our people in a state of perpetual dependence.” He strongly denounced what he described as “pathetic, short sighted and irresponsible approach to the betterment of our people at a time when our communities and nation need us more than ever.”He congratulated Thomas-Sanford on her “bold” initiative as well as the course participants who despite the odds, completed the programme.Certification will be done by the Caribbean Association of National Training Agencies and participants will receive a Caribbean Vocational Qualification certificate (CVQ) to be issued by the Grenada National Training Authority ably facilitated by Abraham Durand.Some smiling faces at the graduation ceremony
Related News Rajnath Singh on two day visit to Eastern Naval Command Advertising By Express Web Desk |New Delhi | Published: July 17, 2019 5:35:21 pm K Natarajan to be new Coast Guard DG IAI will provide a range of maintenance and other services for various sub-systems of MSRAM air defence system. (Source: IAI)Israel Aerospace Industries (IAI) Wednesday signed a $50 million follow-up agreement with India to provide complementary Naval MRSAM (medium range surface-to-air missile) systems to the Indian Navy, reported news agency PTI. In a statement issued by IAI, the state-owned company said, “The deal involves follow up order for a range of maintenance and other services for various sub-systems of IAI’s advanced MRSAM ADS.” 7 Comment(s) Bombay HC dismisses pleas against obtaining NOC for buildings near naval establishments As per the contract, the state-owned company will provide a range of maintenance and other services for various sub-systems of IAI’s advanced MSRAM air defence system.The executive vice president and general manager of Systems, Missiles & Space Group at IAI Boaz Levi, described the deal as a major “breakthrough” and spoke about how the deal reflects the ‘strong relationship’ between IAI and Indian Navy.“This contract is a breakthrough as it advances us from system development and delivery to looking after the operational needs of our customers. IAI’s partnership and strong relationship with the Indian Navy is reflected in all activities with our partners in India. Only recently we have successfully completed a multi-system trial in India that demonstrated the advanced technological centralised management capabilities of the air defence system to the utmost satisfaction of our Indian partners,” he was quoted as saying by PTI.MRSAM provides broad as well as topical defence against a range of assault air, marine and ground threats and comprises several key state-of-the-art systems, including a digital radar, command and control, launchers, and interceptors with advanced homing seekers.
By Reuters |Stockholm | Published: July 15, 2019 9:51:19 am Advertising Related News The small plane designed to carry parachutists crashed on an island on the Ume river shortly after take off, police spokesman Peder Jonsson said, adding the cause for the accident was unknown. He said those on board were on a skydiving trip.The region’s main University Hospital of Umea confirmed there were no survivors and relatives of the deceased had been notified.Neither Jonsson nor the hospital immediately identified the victims’ names or nationalities. Emergency services attend the accident site at a small harbor at Ume river, outside Umea, Sweden, Sunday July 14, 2019. Swedish officials say a small plane carrying parachutists crashed in northern Sweden and all nine of the people on board were killed. (Samuel Pettersson/TT via AP)Nine people were killed when their plane crashed during a skydiving trip near Umea, a small university city in northern Sweden, authorities said on Sunday. People in Sweden switch to trains to deter global warming Post Comment(s) Explosion in southern town in Sweden injures 25, cause unclear Sweden rejects China’s request to extradite ex-official Qiao Jianjun
A World View John P. Mello Jr. has been an ECT News Network reportersince 2003. His areas of focus include cybersecurity, IT issues, privacy, e-commerce, social media, artificial intelligence, big data and consumer electronics. He has written and edited for numerous publications, including the Boston Business Journal, theBoston Phoenix, Megapixel.Net and GovernmentSecurity News. Email John. Fallen Leader Emphasis on Creativity Apple certainly has strengthened its position in the market with this announcement, noted Rhoda Alexander, director of tablet and notebook research at IHS Markit.The lower price point for iPad will help its position in the education market, as well as moving Classroom to the Mac ecosystem, she suggested.”The ecosystem is a huge piece of it,” Alexander told TechNewsWorld, “so watch for developments on ClassKit, Apple’s new software development tool.”Chromebooks have a very strong hold on the U.S. education market at present, she acknowledged, noting that cost and ease of use played a large role in that success.”When looking at Apple, though, you always have to think beyond the U.S. and recognize this is a global play,” Alexander pointed out. “The situation differs dramatically across geographies, and Apple is always planning globally. The initial focus is U.S., but taking initiatives global is always part of the plan.” Apple’s New 9.7-inch iPad and Apple Pencil Once a leader in the education market, Apple has taken a backseat to Google in recent times. In 2013, about half the mobile devices shipped to schools were Macs and iPads. In 2016, about 58 percent of the 12.6 million mobile computing devices shipped to primary and secondary schools were Chromebooks, according to Futuresource Consulting.In rebooting its educational efforts, Apple will face some sizable hurdles, observed Charles King, principal analyst at Pund-IT.”The company abandoned the leadership position in education it once enjoyed so long ago that it’s essentially starting over from scratch,” he told TechNewsWorld.”Moreover, it’s going up against a formidable competitor — Google — with a wide and deep channel of education-focused channel partners and dedicated customers,” King said.The costs associated with switching also pose a problem for Apple, he added. Moving from Google Docs to iWork would create retraining and support costs. Since tablets aren’t as durable as clamshell computers, there might be replacement cost issues to consider too.”This is not going to be an easy market for Apple to reenter, let alone lead,” King said. The Apple team demonstrated a number of new apps that take advantage of the company’s augmented reality development kit, including apps that allow students to take a virtual walk through a museum, interact with wildlife in the virtual wild, and dissect a virtual frog.Apple introduced ClassKit for developing educational software. It expanded its Classroom app to the Mac. It also showcased a new free app, Schoolwork, to help teachers handle assignments and handouts. Further, the company said it would provide 200 GB of free storage on Apple’s iCloud for educational accounts. Apple has moved features found in some of its higher-end products to the more moderately priced new iPad.”Apple has filtered down some of the technologies from the iPad Pro line down to this line,” noted Ross Rubin, principal analyst at Reticle Research.”While they didn’t add the smart connector for an Apple keyboard, they showed off a rugged, Bluetooth keyboard for the tablet that Logitech will be producing,” he told TechNewsWorld.Apple emphasized that the iPad is a creativity tool that’s mobile, Rubin pointed out.”A lot of the focus at the presentation was doing things in the field using the camera and agility of the device,” he said. “You can take it on a trip and do augmented reality things through its camera without having to worry about a keyboard.” Apple on Tuesday announced a refresh of its iPad as part of a new approach to the education market. CEO Tim Cook and other Apple officials also outlined a number of new education initiatives at an event held at Lane Tech College Prep High School in Chicago.The new 32-gigabyte, 9.7-inch iPad, which will sell to consumers for US$329 and to students for $299, has a more powerful processor — Apple’s Fusion A10 chip. It sports a 2048-by-1536-pixel retina display with a ppi of 264. It also supports the Apple Pencil, discounted $10 for the education market.
For many Android users, all the goodies in the latest version of the OS are likely to remain out of their hands for some time, since Pie works only on Pixel models, and a few other phones that participated in the beta program for the software.”It will be telling how quickly Android P is able to migrate to Samsung and Huawei smartphones, and then on to those that run Android One,” McQueen said.Even for those who are able to get their hands on the new OS, there could be challenges.”The issue always is how quickly will people be able to recognize some of these new features,” and whether these devices are “getting too complex for their own good,” Stofega said.”These devices are becoming Swiss Army knife-like,” he remarked. “Device makers have to figure out and adjust to what people really need versus what’s technically possible.” Multi-Camera and HEIF Support Android’s photographic capabilities are expanded in Pie. It supports multiple cameras, which enables developers to access streams from a number of physical cameras simultaneously.”Multi-camera support is a potentially cool feature because it impacts the trajectory of immersive augmented reality, mixed reality and virtual reality experiences,” Nguyen said.”Anything that advances immersive is exciting for me, but it’s a long road, so don’t expect to see something with a super impact immediately,” he added. “It’s more of a building block for bigger things to come.”Android Pie also supports a new image format, HEIF. The format provides better compression than the widely used JPEG format without a loss in quality. Apple has been using the format for awhile.A common complaint among consumers is a lack of storage on phones, Nguyen noted.”I’m not familiar with the technical details on HEIF, but I think all consumers can appreciate having more room because of better compression,” he said. Screen Slices Possible Pain Points Fighting Phone Addiction John P. Mello Jr. has been an ECT News Network reportersince 2003. His areas of focus include cybersecurity, IT issues, privacy, e-commerce, social media, artificial intelligence, big data and consumer electronics. He has written and edited for numerous publications, including the Boston Business Journal, theBoston Phoenix, Megapixel.Net and GovernmentSecurity News. Email John. Better Security Another new addition to Android is App Actions. It makes connections between when and how you use apps and makes suggestions based on those connections. For example, it’s 5:15 p.m. on a Monday. App Action may ask if you want to open the e-book you’ve been reading on your commute to and from work for the past week.Google also announced a feature for Android Pie called “Slices,” which won’t appear in the OS until later this fall.Slices shows relevant information from apps depending on a user’s screen activity. So if a user started typing Lyft into Google Search, Slice would display a slice of the Lyft app with information such as prices to a destination and the ETA for a driver.”Slices is great because it brings us a step closer to the post-app world,” Nguyen said.”Instead of searching through a dozen of apps and individually opening them,” he continued, “the UI allows me to use them with fewer steps.” While the new digital health features may be embraced by some users, they could be annoying to others.”I can see things like Wind Down and app timers getting in the way,” IDC’s Stofega told TechNewsWorld. “I thiink people want to use their devices whenever and however they want.” The power management feature works without adding additional hardware, McQueen pointed out.Huawei introduced performance-enhancing AI in its Mate 10 Pro product, he said, but to do it, the company had to add a chip to the device, which it called a “neural processing unit.””There’s not much going on in terms of new battery technology that can lengthen battery life, so Adaptive Battery could be a good thing,” suggested William Stofega, program director for mobile phones and drones atIDC, a market analysis company based in Framingham, Massachusetts.The Adaptive Battery feature appears to be compelling, acknowledged Tuong Nguyen,a senior principal analyst at Gartner, a research and advisory companybased in Stamford, Connecticut. However, he is withholding judgment on the feature until the verdict from users comes in.”We see a lot of power optimization announcements, and I’m sure they work well enough,” Nguyen told TechNewsWorld, “but my perception as a consumer is that I can never stay sufficiently charged and am always using too much battery.” Seeing Will Be Believing Android Pie also sports a new single home button for simpler navigation.In addition, Android’s Overview feature has been redesigned to display full screen previews of recently used apps. It also now supports Smart Text Selection, providing action suggestions based on selected text.Security has been beefed up in Android 9. It has an improved security model for biometrics. It uses a secure, dedicated chip to enable hardware security capabilities that protect sensitive data, such as credit card information.Android 9 chooses the TLS protocol by default, as well as DNS over TLS, to help protect all Web communications and keep them private. Adaptive Brightness and Adaptive Battery are two ways Android Pie uses AI to customize and improve a phone’s performance.Adaptive Brightness learns what brightness levels a user likes in certain conditions and automatically adjusts the display to those settings when those conditions arise.Adaptive Battery plugs into Google’s DeepMind systems and can learn a person’s phone usage patterns and make adjustments to optimize power usage.”Users of the Android P beta program on Google Pixel phones found a 20 percent increase in battery life,” said David McQueen, research director for consumer devices in the London offices of ABI Research, a technology advisory firm.”Battery life has always been a major pain point for the smartphone user, so this implementation of AI will be welcome relief,” he told TechNewsWorld. With concerns rising about how much time people spend with their phones, Google decided to add some time management features to Android Pie.”While much of the time we spend on our phones is useful, many of us wish we could disconnect more easily and free up time for other things,” observed Google’s Samat.”In fact, over 70 percent of people we talked to in our research said they want more help with this,” he added. “So we’ve been working to add key capabilities right into Android to help people achieve the balance with technology they’re looking for. “The new “digital well-being” features that will be added to Android Pie this fall include the following:A Dashboard that helps users understand how they’re spending time on their devices; An App Timer that lets an operator set time limits on apps and grays out the icon on their home screen when the time is up;A Do Not Disturb mode, which silences all the visual interruptions that pop up on a screen; andWind Down, which switches on Night Light and Do Not Disturb and fades the screen to grayscale before bedtime. Artificial Intelligence plays a big role in Android 9, the latest version of Google’s mobile operating system, released Monday.Called “Android Pie,” the OS is designed to learn from its users’ behavior, and apply those lessons to simplify and customize their phone experiences.”From predicting your next task so you can jump right into the action you want to take, to prioritizing battery power for the apps you use most, to helping you disconnect from your phone at the end of the day, Android 9 adapts to your life and the ways you like to use your phone,” noted Sameer Samat, Google’s vice president of product management for Android and Google Play.
Tesla’s comments last week included some crowing about how its new self-driving computer was massively more powerful than Nvidia’s Drive Xavier platform. Tesla’s platform is 144 TOPS (trillion operations per second) while Nvidia’s Drive Xavier is only 21 TOPS (it actually does 30 TOPS, but this is a nit). This is comparable to Ford comparing the horsepower in its Mustang to Honda’s horsepower in its motorbike.Nvidia Drive Xavier is a cruise control enhancement product — it isn’t self-driving at all. It does have an enhanced product — still mostly cruise control enhancing — that will do 160 TOPS. However, its autonomous driving platform, Nvidia Drive AGX Pegasus, currently does 320 TOPs — well over twice Tesla’s technology — and it may not be enough.The other car makers — currently, most are working with Nvidia — know this. Tesla isn’t fooling anyone who counts. Tesla basically announced that if you want to make sure your autonomous driving technology is safer, better, smarter, and actually does self-driving, then you should buy Nvidia’s solution.Oh, and if you do, it will beat the crap out of what Tesla plans to field. So, if you want to beat Tesla, Tesla basically pointed to Nvidia’s Drive AGX Pegasus as its kryptonite. Granted, after seeing this quarter’s financial results and the insane salary Elon Musk is getting, I’m thinking maybe Musk is a far bigger problem for the company than Nvidia ever could be. Before moving on, I want to share something I find really annoying about the challenges to autonomous driving that some people have been mounting, based on what they call “ethics rules.”The typical argument goes something like this: “If an autonomous car is heading for a cliff and there are kids on both sides, it must be able to make the decision whether to kill the driver or kill the kids and save the driver.” A variant suggests a school bus instead of kids, but it is all BS.How many times have you heard of a car heading for a cliff, or a school bus with kids on both sides, or kids and a wall, or any of this crap? The odds of this ever happening are almost impossibly small, and the odds of it happening to you fall well behind winning all the lotteries on the same day.That doesn’t mean a car doesn’t need to make decisions — but it will virtually always do better than you would do. For instance, if a kid runs out from between two cars, chances are you will hit the kid or crash, because you just can’t think fast enough, generally won’t see the kid coming, and you likely will be driving too fast in a residential area.An autonomous car might still hit the kid, but the odds are far better that it won’t, because it is thinking at computer speeds, it more often will see the kid coming, and it won’t be speeding. Think of it more like smarter anti-lock brakes. Yes, with anti-lock brakes we still have accidents, but there are likely a ton less of them because the issues associated with locking up brakes are largely removed.In all cases, the computer will do better than you would do, because it can think faster and will see more, and it won’t be doing stupid things like speeding or reading email. The only real risk is that some company will cut corners on the system or the driver will override it. Minimum TOPS The opinions expressed in this article are those of the author and do not necessarily reflect the views of ECT News Network. Now Nvidia seems to think that 160 TOPS isn’t enough for autonomous driving, and thus it has a 320 TOPS system. Given that this is a safety system, the focus should be on setting minimum performance requirements.I’m a car guy myself, and I love to drive, but the reason I support autonomous driving is because of the thousands of lives it is forecast to save.I currently don’t drive on holidays if I don’t need to because of concerns about drivers under the influence. I expect that like most of you, I’ve had close calls because some drivers are more interested in what is on their phones than in controlling their cars.Still, autonomous driving has to be done right. The accidents by Autopilot-driven Teslas and some of the test cars highlight that if you don’t get this right, bad things happen. None of us want to replace one big problem with another. Thus, the focus needs to be predominantly on safety, I think — not who has the most operations per second.This means attention must be given not only to sensors, but also vehicle design. I still think autonomous cars need to be designed more to optimize sensor efficiency than to make them look like conventional cars, which is the current approach. Further, the interaction between people and these systems needs to be thought through fully.In that regard I’m concerned about Level 3 and 4 systems — the kind Tesla is promoting. Right now, if they get into trouble, they pass control over to a human. Because humans don’t process information at supercomputer speeds, it’s likely that these situations often will have bad outcomes.I have a mental picture of kicking back in my self-driving car, reading a book, eyes drooping, when suddenly there’s an alert that it is giving control over to me. I look up only to see the huge grill of a semi coming at my windshield. My final words are “Oh, cra…..”Up through Level 4, I’m fonder of the Guardian Angel model that Toyota proposed. The driver stays engaged and the car just ensures that I don’t screw up . If the system takes control, it owns it. Level 5 cars shouldn’t even have user controls. People seem to prefer this anyway, according to Intel surveys, as it removes pressure from the passengers who apparently worry that they otherwise might have to step in. Phony Autonomous Driving Scenarios Basically, the tool monitors you for several days and then builds a profile on how you normally work. For instance, you probably don’t regularly start uploading lots of files, start encrypting entire volumes, or start wandering through random emails. You have a cadence that distinguishes how you type, a normal typing speed, and you use a mouse or touchscreen surprisingly consistently.In addition, you likely have your phone with you when you work on your PC, and you generally are not in two places at once, so the system keeps track of where you are. Once it learns you, if someone else gains access to your system or tries to log on remotely, it identifies that it isn’t you within a few keystrokes or actions, and it locks the intruder out of your PC. If there’s an attempt to access your stuff, say, from Nigeria — and it knows you are in New York — that login attempt will fail.Like most current AI systems, the false negatives and false positives are exceedingly low. This effectively creates a dual or multiple factor authentication system that can move with you system to system. Even if you have the crappiest ID and password on the planet, it still can ensure that you aren’t compromised.Because being both safe and secure is important to me, CylancePERSONA is my product of the week. Wrapping Up: Is Nvidia Tesla’s Kryptonite? Tesla sure didn’t have a good week last week, given the kind of press coverage it got. (I just did a search and this was the top result when my search box autofilled “Tesla is going bankrupt” — apparently this is a popular search topic.) The company’s latest quarterly results were astonishingly bad. I’m not that worried about Tesla going away, though, as its products are far too popular for it to disappear. On the other hand, management clearly needs to be fixed.What got me started looking at Tesla last week was that it pretty much announced that Nvidia was its Kryptonite. Here’s what I mean: In the case of Superman, he is pretty much indestructible, except for his vulnerability to the rare kryponite — fragments of his obliterated home planet Krypton that made it to Earth. Superman would never have a press event pointing out that if you wanted to kill him, this would be how to do it.Yet that seemed to be what happened when Tesla spoke about its new self-driving car technology and pointed out, inaccurately, that what it had was better than Nvidia’s tech. That alone wouldn’t be enough to warrant a column. However, it occurred to me that we really haven’t set a bar for the minimum needed for true autonomous driving. When you talk about things that can weigh tons and move at freeway speeds, that is a huge oversight. However, what Tesla has proposed likely isn’t even close.I’ll share some thoughts on Tesla, Nvidia and autonomous driving and close with my product of the week: something interesting from BlackBerry/Cylance that not only could make passwords obsolete but also could keep your PC from being compromised. To say I hate passwords with a passion would be an understatement. Back in the 1980s, we did a study at IBM to determine where the greatest vulnerability existed in every company, and passwords won by a significant margin.Here we are, more than 30 years later, and we are still talking about how bad passwords and IDs are, and they are still the predominant way we gain access to our stuff. Even with all of the breaches, the passwords “123456” and “PASSWORD” are still incredibly common. Even if we have a good one, the ease with which someone can trick us into giving up our password is embarrassing.The BlackBerry analyst event last week featured what may be one of the best solutions I’ve ever seen. Called “CylancePERSONA,” it uses AI to determine who you are. This isn’t just for log in purposes — it can tell if someone else got access to your laptop or smartphone and lock them out. Not really. From what I can see, right now, Musk is Tesla’s kryptonite. The guy seems to be doing his level best to kill the company that he created, which brings up an old study I read in college. That study indicated that CEOs typically are good at one or two phases in a company’s creation but never three.Those three phases are inception (when the company is first formed), transition (when the firm moves from inception to a sustaining enterprise) and sustaining (when the firm reaches a stable state). The issue, according to the study, is that startup CEOs tend to thrive on risk and excitement and micromanage to excess. They aren’t good with regulatory bodies because they generally don’t have to deal with them.So, if they stay too long, they tend to become problems, because they create excitement, run afoul of regulatory bodies, and drive folks nuts with micro-management. I think that accurately describes the problems we are seeing with Elon Musk.Nevertheless, Tesla needs to stop overpromising and underdelivering on safety features like autonomous driving. People are getting hurt, and that isn’t the way to treat one of the most loyal customer groups on the planet. It isn’t a good way to treat anyone, really. Do it right or don’t do it at all. CylancePersona from BlackBerry Rob Enderle has been an ECT News Network columnist since 2003. His areas of interest include AI, autonomous driving, drones, personal technology, emerging technology, regulation, litigation, M&E, and technology in politics. He has an MBA in human resources, marketing and computer science. He is also a certified management accountant. Enderle currently is president and principal analyst of the Enderle Group, a consultancy that serves the technology industry. He formerly served as a senior research fellow at Giga Information Group and Forrester. Email Rob. Tesla’s Comments
Source:https://canal.ugr.es/noticia/obesity-and-food-restrictions-proven-to-be-associated-with-less-food-enjoyment/ Reviewed by Alina Shrourou, B.Sc. (Editor)Nov 13 2018Researchers from the University of Granada (UGR) belonging to the Mind, Brain and Behavior Research Center (CIMCYC, from its name in Spanish) and the Faculty of Business and Economics have proven that adolescents who suffer from obesity feel less food enjoyment than those who have a normal weight. In addition, their work reveals that even trivial restrictions on food intake (that is, temporary diets) are associated with a reduction in pleasure.For this work, published in the journal Food Quality and Preference, a large sample of 552 adolescents between 11 and 17 years old from several high schools in Granada has had their emotional reactions analyzed during the visualization of images of sweet foods.Related StoriesResearchers propose new avenue in the search for anti-obesity drugsSupervised fun, exercise both improve psychosocial health of children with obesityNew technique reduces postoperative deficit of oxygen in the blood in patients with morbid obesityThus, the researchers observed that those adolescents who reported different types of dietary restrictions (different types of diet, dieting very often, skipping breakfast, eating less frequently, etc.), along with those who were obese and those who had unhealthy behaviors unrelated to food (such as smoking or having insufficient sleep), felt less pleasure, attraction and desire to eat the highly palatable foods they were looking at (images of sweets, donuts, ice‑creams, chocolate crêpes, etc.).As explained by Laura Miccoli, main author of this study, “adolescence, typically associated with greater body dissatisfaction, is a key stage for the development of risky eating behaviors, related both to uncontrolled restrictions on food intake -which may lead to to the development of eating disorders- and with the stabilization of overweight and obesity.” Hence the importance of studies that approach both food‑related disorders from an integrative perspective.A pioneering studyNot in vain, the research led by the UGR is the first study that has examined the adolescents’ emotions toward sweet food cues based on a constellation of risk behaviors, related to both obesity and eating disorders.In the light of the results obtained, the UGR scientists point out that those adolescents who feel more pleasure or enjoyment when eating “have a healthy relationship with food, and this pleasure may be a possible protective factor against eating and weight‑related disorders.”Therefore, “consistent with recent prevention strategies, it is important to change the perspective on the enjoyment of food with respect to the prevention of obesity, banishing the idea that we should avoid the pleasure of eating. On the contrary: we should take advantage of it, and make food enjoyment -the ‘slow food movement’- a tool for healthy eating,” Miccoli points out.
Reviewed by James Ives, M.Psych. (Editor)Mar 20 2019Next-generation sequencing of tumor DNA from patients with colorectal cancer revealed genetic alterations that were linked to different survival and treatment outcomes in an analysis led by a University of North Carolina Lineberger Comprehensive Cancer Center researcher.The findings, published in the Journal of Clinical Oncology, could help define strategies to more effectively treat colorectal cancer, the second leading cause of cancer death in the United States.”This is an example of precision oncology, where using genetics, we are able to stratify tumor types that we once believed were homogeneous, and to identify new patient subgroups that might benefit from tailored therapies,” said UNC Lineberger’s Federico Innocenti, MD, PhD, associate professor in the UNC Eshelman School of Pharmacy Division of Pharmacotherapy and Experimental Therapeutics.For the study, researchers analyzed mutations in tumors of 843 patients who participated in a phase III clinical trial. The trial compared treatment with chemotherapy plus either bevacizumab or cetuximab – regimens which are now the standard of care for this disease in the advanced stage. The researchers used tumor samples to analyze genetic mutations in the DNA. Then, they examined associations between the mutations and data on patients’ responses to the treatments and survival.One key finding from the analysis was that patients who had a lot of genetic repeats in their tumor DNA – known as microsatellite instability – had longer survival when treated with bevacizumab compared to patients treated with cetuximab.”This finding has important potential implications for treatment of patients with microsatellite instability – a subgroup that represented about 7 percent of patients in our study,” Innocenti said.Related StoriesSugary drinks linked to cancer finds studyBacteria in the birth canal linked to lower risk of ovarian cancerStudy reveals link between inflammatory diet and colorectal cancer riskAnother key finding was that patients with tumors that had more genetic variation, which they called high tumor mutational burden, lived longer than patients who had tumors with less variation. The level of tumor mutational burden defines a new subgroup of patients with better prognosis, Innocenti reported.Studies are ongoing in Innocenti’s lab to try to understand the role of the body’s immune system in contributing to the finding. Researchers want to know if these patients with higher tumor mutational burden will be more responsive to treatments that work by unlocking the immune system against cancer.”It is crucial to define which patients could be responsive to immunotherapy in this setting, and this study shows the first promising evidence to do so,” Innocenti said.The study also confirmed findings previously made for patients who had mutations in the BRAF gene in their tumors. They found these patients had worse survival compared to patients who didn’t. Median survival for patients with the mutation was 13.5 months, compared to 30.6 months in patients without mutations.”This mutation was a very strong negative prognostic factor,” Innocenti said. “There was a clear difference in survival.”There was no difference in the study between the different treatment strategies studied in the trial for patients with or without the BRAF mutation. However, Innocenti said the finding confirms these tumors have a different biology and should be treated differently.Additional studies are needed to evaluate and confirm findings with therapeutic implications in patients, Innocenti said. Further research is planned to study additional ways of stratifying patients based on their genetic features to improve outcomes. Source:https://unclineberger.org/news/precision-oncology-insights-revealed-for-colorectal-cancer/
Source:https://news.illinois.edu/view/6367/775169 Reviewed by James Ives, M.Psych. (Editor)Apr 17 2019Oxidants found within living organisms are byproducts of metabolism and are essential to wound-healing and immunity. However, when their concentrations become too high, inflammation and tissue damage can occur. University of Illinois engineers have developed and tested a new drug-delivery system that senses high oxidant levels and responds by administering just the right amount of antioxidant to restore this delicate balance.The findings are published in the journal Small.Many pharmaceuticals include specialized polymers and particles that control the timing or concentration of the drug released once administered, the researchers said. However, these additives can hamper crystallization during the manufacturing phase of some drugs – like antioxidants – causing them to dissolve in the body in an uncontrolled manner.”We saw an opportunity here to develop a different kind of drug-delivery system that could sense the level of oxidant in a system and respond by administering antioxidant as needed,” said chemical and biomolecular engineering professor and study co-author Hyunjoon Kong.Kong and his team found a way to assemble crystals of catechin – the bright green antioxidant found in green tea – using a polymer that can sense when oxidant concentrations become too high. The researchers tested the responsiveness of the resulting catechin crystal-containing polymer in the common freshwater planktonic crustacean Daphnia magna, the water flea.”Heart rate is an indication of the extent to which potentially toxic chemicals influence physiology in water fleas,” Kong said. “Daphnids are often used to monitor environmental impacts on ecological systems, and because their hearts are similar to those of vertebrates, they are also used to evaluate the efficacy of cardioprotective drugs.”Related StoriesChronic inflammation removes motivation by reducing dopamine in the brainCancer incidence among children and young adults with congenital heart diseaseStudy measures antioxidant levels in edible insectsThe researchers exposed the daphnids to water contaminated with sublethal concentrations of the natural oxidant hydrogen peroxide while monitoring their heart rate. They found that the daphnids’ mean heart rates dropped from 348 to 290 and 277 beats per minute, depending on the concentration of hydrogen peroxide used.When the team added the new catechin crystal assembled with polymer to the experiment, the water fleas eventually recovered a close-to-normal heart rate.Beyond the potential pharmaceutical uses for the new polymer, Kong’s group is looking into its use for curtailing the impact of highly oxidizing chemicals in natural waterways.”Hydrogen peroxide is often used to clean water fouled by excessive algae, and this raises concern about how the oxidant may be affecting living organisms in water,” he said. “We think this new antioxidant-delivery system could be used to address the problem of over-oxidized natural waters.”The researchers plan to push ahead with developing the polymer for pharmaceutical and environmental uses. “This study proved a concept, but we have more work to do,” Kong said. “There is concern over the safety of the specific polymer we used – polyethylenimine diselenide – but we are getting close to finding a viable replacement.”
Those who used a vitamin D supplement, were less likely to be vitamin D deficient as may be expected, but supplement use was low (4.4%) and, therefore, food fortification and other strategies need to be considered at policy level for older populations.” Reviewed by Alina Shrourou, B.Sc. (Editor)Jun 13 2019Over a quarter of adults aged 50+ are deficient in vitamin D according to researchers from Trinity College Dublin who announced their findings today (Thursday, June 13th). Over half (57%) had inadequate serum vitamin D levels, of which 26% were classed as vitamin D deficient. Vitamin D has a known role in bone health, with growing evidence for beneficial effects on muscle strength and other non-skeletal outcomes. The study was recently published in the international, peer-reviewed journal Nutrients.Better understanding of factors that contribute to vitamin D deficiency is needed to identify people most at-risk. Determinants of deficiency identified in this new study were female gender, advanced age (80+ years), smoking, non-white ethnicity, obesity and poor self-reported health. Researchers therefore identified a profile of older people more likely to be at risk of vitamin D deficiency. Being of a healthy weight, retired, engaging in regular vigorous physical activity, vitamin D supplement use, sun travel in past 12 months and summer season were positive determinants, and therefore potentially protective factors against vitamin D deficiency in older people.The findings were based on 6004 midlife and older adults, living at Northern latitudes (England, 50-55oN) derived from the English Longitudinal Study of Ageing (ELSA). Since UVB radiation (sunlight) is a known determinant of vitamin D status, this was investigated. Interestingly, residents in the South of England had a reduced risk of deficiency, compared with the North, even after adjustment for socioeconomic and other predictors of vitamin D status.This new research demonstrates that vitamin D deficiency is prevalent in older adult populations living at Northern latitudes and highlights the importance of public health strategies throughout midlife and older age to achieve optimal vitamin D status.Related StoriesSunscreen benefits can be obtained without compromising vitamin D levelsVitamin D deficiency at birth increases risk of high blood pressure in childrenVitamin D could extend lifespan of cancer patientsAssociate Professor in Nutrition at Trinity College, Maria O’Sullivan commented ‘Our study identified factors associated with vitamin D deficiency, including being aged 80+ years, obesity and sedentary lifestyles; all of which are increasing traits in western populations. Furthermore, this is one of the few studies to highlight the importance of non-white ethnicity in vitamin D deficiency in a large study of aging. The findings are valuable in developing targeted strategies to eliminate vitamin D deficiency (at 30nmol/L) in older populations’.First Author Dr Niamh Aspell, who conducted the study as part of her PhD at Trinity said: Source:Trinity College DublinJournal reference:Aspell, N. et al. (2019) The Prevalence and Determinants of Vitamin D Status in Community-Dwelling Older Adults: Results from the English Longitudinal Study of Ageing (ELSA). Nutrients. doi.org/10.3390/nu11061253. Co-Author and Trinity Research Fellow Dr Eamon Laird, said: The high rates of deficiency are similar to rates seen in other high latitude countries such as Ireland. However, other more northern countries such as Finland have implemented a successful vitamin D fortification policy which has all but eliminated deficiency in the population. Such a policy could easily be implemented in the UK and Ireland.”
70% of HGSC relapse despite treatment, becoming resistant to chemotherapy, which makes the new discovery a true potential breakthrough in the treatment of this tumor.All life at cellular and organism level depends upon thousands of life processes that provide and degrade a range of chemicals required for proper function of the cells and tissues. These intricately interdependent processes together they make up the body’s metabolism. By Dr. Liji Thomas, MDJul 14 2019A new study shows that targeting a specific protein found within quickly spreading high-grade serous carcinomas (HGSC) of the ovary could help contain these cancers. HGSC is the most common and deadly form of epithelial ovarian cancer, which is itself the deadliest cancer of the female reproductive tract. When HGSC spreads outside the ovaries, within the peritoneal cavity, it forms detached balls called spheroids, which may look and act differently from the adherent cells of the primary tumor.The study is published in the current issue of the journal Molecular Cancer Research. However, as researcher Erika Dahl explains, “A hallmark of cancer cells is that their metabolic processes are often different from normal, healthy cells.” This is called metabolic reprogramming. As one of the outcomes, study author Katherine Aird says, “Cancer cells can grow forever without stimulus.” Cancer cell Illustration. Image Credit: Jovan Vitanovski / Shutterstock The good news about the newly discovered protein is that it can be inhibited, thus inactivating cell processes within ovarian cancer cells to switch them from a constitutively proliferative cell cycle to one which results in senescence, or going to sleep. The key role of the protein was identified on cell culture experiments by researchers at Penn State College of Medicine.The current study focused on teasing out the differences in the metabolism of ovarian cancer cells by comparing them with cells from a normal fallopian tube.The route used to achieve this was quantitative spectrometry, which helped analyze the metabolites produced by various cellular pathways in the two type of tissue. Among the differences, it was revealed that cancer cells utilized glucose, a form of sugar, via the key energy cycle called the citric acid cycle, far more often, as against the more common use of an oxygen-requiring pathway called aerobic glycolysis. This accounts for the presence of a high level of citric acid activity in all high-grade serous ovarian cancer cells. Related StoriesStudy reveals link between inflammatory diet and colorectal cancer riskVirus killing protein could be the real antiviral hero finds studyNew study to ease plight of patients with advanced cancerThis means that many therapies which inhibit the breakdown of glucose (glycolysis) to destroy cancer cells may be quite ineffective. Dahl commented that this could often result, in fact, in the production of toxins that harm normal healthy tissue.Instead, the team in the current study looked at the effects of inhibiting the wildtype or normal form of an enzyme, isocitrate dehydrogenase 1 (IDH 1), which plays a vital part in the citric acid cycle. They selected this protein because it was the only one in this pathway that is expressed at higher levels in both adherent and spheroid tumor cells. Increased activity of this enzyme severely impacts progression-free survival, which is an important outcome measured in assessing the effectiveness of any cancer therapy.Mutants of this protein are common in other tumors, but the wildtype form is typically present in cells within HGSC. The researchers hypothesize that the presence of this enzyme is an important advantage to these cells, and its inhibition is a key step to inducing senescence.The researchers found that suppressing the work of this protein stopped cell division completely by suppressing the activity of multiple other genes, inhibiting vital metabolic pathways. Both adherent cells of the primary tumor, and spheroid cells of secondary HGSC, become senescent when the wildtype IDH 1 enzyme is inhibited. Thus, this could be an excellent way to treat HGSC at all stages. This is an important consideration, as ovarian cancers are rarely diagnosed at early stages.While there are already FDA (US Food and Drug Administration)-approved drugs against one of the mutant forms of this enzyme, the team wondered whether they would work against the wildtype form as well. They found that one did, and this is now a part of their continued research agenda.Aird says, “One of our long-term goals is to try and repurpose this already-approved drug as a treatment for this form of ovarian cancer.” Besides adapting existing drugs against the enzyme to fight this type of cancer, the researchers want to examine the differences in the metabolic functioning of normal and HGSC cells more closely. Another goal is to examine the effectiveness of combining IDH 1 inhibitors with other treatments. Journal reference:Targeting IDH1 as a Prosenescent Therapy in High-grade Serous Ovarian Cancer, Erika S. Dahl, Raquel Buj, Kelly E. Leon, Jordan M. Newell, Yuka Imamura, Benjamin G. Bitler, Nathaniel W. Snyder and Katherine M. Aird, Mol Cancer Res June 17 2019 DOI: 10.1158/1541-7786.MCR-18-1233, http://mcr.aacrjournals.org/content/early/2019/06/17/1541-7786.MCR-18-1233
Explore further Britain called for a first-of-its-kind watchdog for social media that could fine executives and even ban companies. And a European Union parliamentary committee approved a bill giving internet companies an hour to remove terror-related material or face fines that could reach into the billions.”We are forcing these firms to clean up their act once and for all,” said British Home Secretary Sajid Javid, whose department collaborated on Britain’s proposal.Opponents warned the British and EU measures could stifle innovation and strengthen the dominance of technology giants because smaller companies won’t have the money to comply. That, in turn, could turn Google and Facebook into the web’s censors, they said.The push to make the big companies responsible for the torrent of material they carry has largely been driven by Europeans. But it picked up momentum after the March 15 mosque shootings in New Zealand that killed 50 people and were livestreamed for 17 minutes. Facebook said it removed 1.5 million videos of the attacks in the 24 hours afterward.The U.S., where government action is constrained by the First Amendment right to free speech and freedom of the press, has taken a more hands-off approach, though on Tuesday, a House committee will press Google and Facebook executives on whether they are doing enough to curb the spread of hate crimes and white nationalism.Australia last week made it a crime for social media platforms not to quickly remove “abhorrent violent material.” The offense would be punishable by three years in prison and a fine of 10.5 million Australian dollars ($7.5 million), or 10% of the platform’s annual revenue, whichever is larger. New Zealand’s Privacy Commissioner wants his country to so the same.The British plan would require social media companies such as Facebook and Twitter to protect people who use their sites from “harmful content.” The plan, which includes the creation of an independent regulator funded by a tax on internet companies, will be subject to public comment for three months before the government publishes draft legislation. Citation: Facebook, Google face widening crackdown over online content (2019, April 9) retrieved 17 July 2019 from https://phys.org/news/2019-04-facebook-google-widening-crackdown-online.html Tech giants like Facebook and Google came under increasing pressure in Europe on Monday when countries proposed stricter rules to force them to block extreme material such as terrorist propaganda and child porn. In this April 18, 2017 file photo, conference workers speak in front of a demo booth at Facebook’s annual F8 developer conference, in San Jose, Calif. The U.K. for the first time on Monday April 8, 2019, proposed direct regulation of social media companies, with senior executives potentially facing fines if they fail to block damaging content such as terrorist propaganda or images of child abuse. (AP Photo/Noah Berger, File) “No one in the world has done this before, and it’s important that we get it right,” Culture Secretary Jeremy Wright told the BBC.Facebook’s head of public policy in Britain, Rebecca Stimson, said the goal of the new rules should be to protect society while also supporting innovation and freedom of speech.”These are complex issues to get right, and we look forward to working with the government and Parliament to ensure new regulations are effective,” she said.Britain will consider imposing financial penalties similar to those under the EU’s online data privacy law, which permits fines of up to 4% of a company’s annual worldwide revenue, Wright said. In extreme cases, the government may also seek to fine individual company directors and prevent companies from operating in Britain.Under the EU legislation that cleared an initial hurdle in Brussels, any internet companies that fail to remove terrorist content within an hour of being notified by authorities would face similar 4% penalties. EU authorities came up with the idea last year after attacks highlighted the growing trend of online radicalization.The bill would apply to companies providing services to EU citizens, whether or not those businesses are based in the EU’s 28 member countries. It still needs further approval, including from the full European Parliament.It faces heavy opposition from digital rights organizations, tech industry groups and some lawmakers, who said the 60-minute deadline is impractical and would lead companies to go too far and remove even lawful material.”Instead, we call for a more pragmatic approach with removals happening ‘as soon as possible,’ to protect citizens’ rights and competitiveness,” said EDIMA, a European trade group for new media and internet companies.Opponents said the measure also places a bigger burden on smaller internet companies than on giants like Facebook and Google, which already have automated content filters. To help smaller web companies, the bill was modified to give them an extra 12 hours for their first offense, a measure opponents said didn’t go far enough.Mark Skilton, a professor at England’s Warwick Business School, urged regulators to pursue new methods such as artificial intelligence that could do a better job of tackling the problem.”Issuing large fines and hitting companies with bigger legal threats is taking a 20th-century bullwhip approach to a problem that requires a nuanced solution,” he said. “It needs machine learning tools to manage the 21st-century problems of the internet.”Wright said Britain’s proposed social-media regulator would be expected to take freedom of speech into account while trying to prevent harm.”What we’re talking about here is user-generated content, what people put online, and companies that facilitate access to that kind of material,” he said. “So this is not about journalism. This is about an unregulated space that we need to control better to keep people safer.” UK takes aim at social networks that fail to quash ‘hateful’ content This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. © 2019 The Associated Press. All rights reserved.
Explore further France is ready to consider cutting its stake in Renault in the interests of consolidating the automaker’s alliance with Nissan, Finance Minister Bruno Le Maire said Saturday. © 2019 AFP This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Renault tries to reassure partner Nissan on Fiat plans Citation: France ready to cut Renault stake to shore up Nissan partnership: minister (2019, June 8) retrieved 17 July 2019 from https://phys.org/news/2019-06-france-ready-renault-staketo-shore.html Le Maire said Renault should concentrate on forging closer ties with Nissan before seeking other alliances He was speaking in Japan after Italian-US carmaker Fiat Chrysler pulled the plug on its proposed merger with Renault, saying negotiations had become “unreasonable” due to political resistance in Paris.In an interview with AFP on the sidelines of the G20 finance ministers meeting in Japan, Le Maire said Paris might consider reducing the state’s 15-percent stake in Renault if it led to a “more solid” alliance between the Japanese and French firms.”We can reduce the state’s stake in Renault’s capital. This is not a problem as long as, at the end of the process, we have a more solid auto sector and a more solid alliance between the two great car manufacturers Nissan and Renault,” he told AFP.Last week, FCA stunned the auto world with a proposed “merger of equals” with Renault that would—together with Renault’s Japanese partners Nissan and Mitsubishi Motors—create a car giant spanning the globe. The combined group would have been by far the world’s biggest, with total sales of some 15 million vehicles, compared to both Volkswagen and Toyota, which sell around 10.6 million apiece.But the deal collapsed suddenly on Thursday, with FCA laying the blame at the door of Paris. “It has become clear that the political conditions in France do not currently exist for such a combination to proceed successfully,” FCA said in a statement.Le Maire said Renault should concentrate on forging closer ties with its Japanese partner Nissan before seeking other alliances.Things need to be done “in the right order…. First the alliance (between Nissan and Renault) should be consolidated and then consolidation (more generally) and not one before the other.””Otherwise, everything risks collapsing like a house of cards,” he warned.The minister said it would be up to the bosses of Renault and Nissan to decide how to push the alliance forward as ties between the two firms have been strained after the shock arrest of former boss Carlos Ghosn.Renault is pushing for a full merger between the pair but there is deep scepticism of the plan at Nissan.There were varied reactions from the French unions Saturday.”The government is behaving like the agent of the big shareholders, favouring short-term profit to the detriment of the interests of the country,” said Fabien Gache, of the CGT union.Cutting the state’s share in Renault was abandoning its responsibility in the country’s auto industry, he argued.Franck Daout of the CFDT union said it backed a three-way alliance between Renault, Nissan and Japan’s Mitsubishi—but not one between Nissan and Renault until the alliance had reached a “safe and sustainable maturity”.
Image Gallery: How Technology Reveals Hidden Art Treasures 7 Amazing Places to Visit with Google Street View Satellite images of the buried ancient Egyptian city Tanis revealed city walls that were invisible to archaeologists on the ground. Credit: Courtesy of Sarah Parcak An eye inlay from a tomb dating to 4,000 years ago, in Lisht, Egypt. The expedition, co-led by Dr. Parcak, was conducted in partnership with the Egyptian Ministry of Antiquities. Credit: Courtesy of Sarah Parcak Satellites analyze landscapes and use different parts of the light spectrum to uncover buried remnants of ancient civilizations. But studying archaeological sites from above had very humble (and low-tech) beginnings, Parcak told Live Science. Researchers first experimented with peering down from a great height at a historic location more than a century ago, when a member of the Corps of Royal Engineers photographed the 5,000-year-old monument Stonehenge from a hot-air balloon. “You could even see — from this very early and somewhat blurry photograph — staining in the landscape around the site, showing that there were buried features there,” Parcak said. Through the 1960s and into the 1970s, aerial photography continued to play an important role in archaeology. But when NASA launched its first satellites it opened up “a completely new world,” for archaeologists in the 1980s and 1990s, Parcak said. In fact, declassified images from the U.S. government’s Corona spy satellite program, which operated from 1959 to 1972, helped archaeologists in the 1990s to reconstruct the positions of important sites in the Middle East that had since disappeared, eradicated by urban expansion. In Photos: Ancient Egyptian Tombs Decorated with Creatures If these stories of space archaeology in Parcak’s book leave readers wanting more, they’re in luck. An online platform called GlobalXplorer, launched and run by Parcak, offers users access to a library of satellite images for browsing and annotation. Aspiring “citizen-scientists” can join “campaigns” to assist in the ongoing search for lost cities and ancient structures, and to help experts identify signs of looting in vulnerable sites, according to the platform website. Since 2017, approximately 80,000 users have evaluated 14 million satellite images, mapping 700 major archaeological sites that were previously unknown, Parcak said. “Archaeology From Space” is available to buy on Amazon. Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 min and see why everyone is addicted!Vikings: Free Online GameUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoGundry MD Total Restore SupplementU.S. Cardiologist: It’s Like a Pressure Wash for Your InsidesGundry MD Total Restore SupplementUndoTop 10 Best Meal DeliveryMeal Kit Wars: 10 Tested & Ranked. See Who WonTop 10 Best Meal DeliveryUndoKelley Blue Book2019 Lexus Vehicles Worth Buying for Their Resale ValueKelley Blue BookUndoArticles VallyDad Cuts Daughter’s Hair Off For Getting Birthday Highlights, Then Mom Does The UnthinkableArticles VallyUndo What does it take to be a space archaeologist? No, you don’t need a rocket or a spacesuit. However, lasers are sometimes involved. And infrared cameras. And spy satellites. Welcome to Sarah Parcak’s world. Parcak, an archaeologist and a professor of anthropology at the University of Alabama at Birmingham, has mapped sites around the world from space; she does so using images captured by satellites — from NASA and from private companies — orbiting high above the ground. From these lofty heights, sensitive instruments can reveal details that are invisible to scientists on the ground, marking the positions of walls or even entire cities that have been buried for millennia. Parcak unpacks how views from space are transforming the field of archaeology, in her new book “Archaeology From Space: How the Future Shapes Our Past” (Henry Holt and Co., 2019). [Read an excerpt from “Archaeology From Space”] AdvertisementArchaeology Gets a Sci-Fi Makeover, In ‘Archaeology From Space’Live Science sits down with archaeologist and author Sarah Parcak to talk about her new book, “”Archaeology From Space: How the Future Shapes Our Past” (Henry Holt and Co., 2019).Volume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Better Bug Sprays?01:33关闭选项Automated Captions – en-US facebook twitter 发邮件 reddit 链接https://www.livescience.com/65924-space-archaeology-highlights.html?jwsource=cl已复制直播00:0020:0420:04Your Recommended Playlist01:33Better Bug Sprays?01:08Why Do French Fries Taste So Bad When They’re Cold?04:24Sperm Whale Befriends Underwater Robot00:29Robot Jumps Like a Grasshopper, Rolls Like a Ball00:29Video – Giggly Robot02:31Surgical Robotics关闭 Today, aerial or satellite images captured by optical lenses, thermal cameras, infrared and lidar — light detection and ranging, a type of laser system — are well-established as part of an archaeologist’s tool kit. And archaeologists need as many tools as they can get; there are thought to be millions of sites around the world that are yet to be discovered, Parcak added. But remote sensing isn’t one-size-fits-all; different terrains require different space archaeology techniques. For example, in Egypt, layers of sand blanket lost pyramids and cities. In that type of landscape, high-resolution optical satellites reveal subtle differences on the surface that may hint at structures underground. And in regions with dense vegetation, such as in Southeast Asia or Central America, lidar emits millions of pulses of light to penetrate beneath the trees and detect hidden buildings, Parcak explained. In her own work, Parcak’s analysis of satellite views led to the creation of a new map for the legendary city of Tanis in Egypt, famously featured in the movie “Raiders of the Lost Ark.” Satellite images of Tanis revealed a vast network of the city’s buildings, which had previously gone undetected even as the site was under excavation, she wrote.