first_imgReviewed by James Ives, M.Psych. (Editor)Mar 20 2019Next-generation sequencing of tumor DNA from patients with colorectal cancer revealed genetic alterations that were linked to different survival and treatment outcomes in an analysis led by a University of North Carolina Lineberger Comprehensive Cancer Center researcher.The findings, published in the Journal of Clinical Oncology, could help define strategies to more effectively treat colorectal cancer, the second leading cause of cancer death in the United States.”This is an example of precision oncology, where using genetics, we are able to stratify tumor types that we once believed were homogeneous, and to identify new patient subgroups that might benefit from tailored therapies,” said UNC Lineberger’s Federico Innocenti, MD, PhD, associate professor in the UNC Eshelman School of Pharmacy Division of Pharmacotherapy and Experimental Therapeutics.For the study, researchers analyzed mutations in tumors of 843 patients who participated in a phase III clinical trial. The trial compared treatment with chemotherapy plus either bevacizumab or cetuximab – regimens which are now the standard of care for this disease in the advanced stage. The researchers used tumor samples to analyze genetic mutations in the DNA. Then, they examined associations between the mutations and data on patients’ responses to the treatments and survival.One key finding from the analysis was that patients who had a lot of genetic repeats in their tumor DNA – known as microsatellite instability – had longer survival when treated with bevacizumab compared to patients treated with cetuximab.”This finding has important potential implications for treatment of patients with microsatellite instability – a subgroup that represented about 7 percent of patients in our study,” Innocenti said.Related StoriesSugary drinks linked to cancer finds studyBacteria in the birth canal linked to lower risk of ovarian cancerStudy reveals link between inflammatory diet and colorectal cancer riskAnother key finding was that patients with tumors that had more genetic variation, which they called high tumor mutational burden, lived longer than patients who had tumors with less variation. The level of tumor mutational burden defines a new subgroup of patients with better prognosis, Innocenti reported.Studies are ongoing in Innocenti’s lab to try to understand the role of the body’s immune system in contributing to the finding. Researchers want to know if these patients with higher tumor mutational burden will be more responsive to treatments that work by unlocking the immune system against cancer.”It is crucial to define which patients could be responsive to immunotherapy in this setting, and this study shows the first promising evidence to do so,” Innocenti said.The study also confirmed findings previously made for patients who had mutations in the BRAF gene in their tumors. They found these patients had worse survival compared to patients who didn’t. Median survival for patients with the mutation was 13.5 months, compared to 30.6 months in patients without mutations.”This mutation was a very strong negative prognostic factor,” Innocenti said. “There was a clear difference in survival.”There was no difference in the study between the different treatment strategies studied in the trial for patients with or without the BRAF mutation. However, Innocenti said the finding confirms these tumors have a different biology and should be treated differently.Additional studies are needed to evaluate and confirm findings with therapeutic implications in patients, Innocenti said. Further research is planned to study additional ways of stratifying patients based on their genetic features to improve outcomes. Source:https://unclineberger.org/news/precision-oncology-insights-revealed-for-colorectal-cancer/last_img read more

first_img Related News Television channels showed police evacuating residents from flooded homes in rubber boats in some parts of Kathmandu where roads were flooded. Families carrying their belongings on their heads waded through waist-deep water.”We have evacuated more than 150 people and are on the standby for rescue in different areas,” army spokesman Bigyan Dev Pandey said.Officials said the Kosi River in eastern Nepal, which flows into the eastern Indian state of Bihar, had risen above the danger mark.The weather office asked residents to remain alert saying heavy rains were expected to continue through the weekend.The annual monsoon rains, which normally start in June and continue through September often result in casualties in Nepal, a country of 30 million people. (Reporting by Gopal Sharma; Editing by Kevin Liffey) KATHMANDU (Reuters) – More than 20 people have been killed or are missing due to landslides and floods as monsoon rains lashed Nepal, the government said on Friday.Heavy rains since Thursday have hit 20 of Nepal’s 77 districts, in the hills as well as in southern plains.A Home Ministry statement said 15 people had been killed, while six others were missing and 13 were injured as incessant rains caused landslides and triggered flash floods in rivers originating in the Himalayas.In the capital, Kathmandu, three members of a family were killed when the wall of their house collapsed. Nation 11h ago German tourist and tour guide missing in Mulu cave flash floods World 07 Jul 2019 Nepal denies Tibetans’ request to hold Dalai Lama birthday celebrationcenter_img China 9h ago Floods affect 19.91 million people Related News {{category}} {{time}} {{title}}last_img read more

It’s how he got to know Anthony Levandowski. 2015. She told me I am good enough to take the tests. " Joji Morishita said at a press conference.[and] never falls (1 Cor 135 7-8) Just as Paul and others had expanded the understanding of agape to make it all-encompassing King in his teaching builds upon Paul and brings out agapes creativity its capacity to create togetherness and community The pestering but important gadfly Kings medium for enacting his teaching civil disobedience was also informed by the Greeks or rather one Greek in particular Three times in his 1963 "Letter from Birmingham Jail" King evokes Socrates (469-399 BC) the philosopher who famously made the public streets and squares of Athens his classroom Kings letter is addressed to fellow clergymen who had discouraged his practice of nonviolent resistance on the grounds that it was "unwise and untimely" and could incite civil disturbances In making the case for the importance of civil disobedience King introduces Socrates as one of its early practitioners: Just as Socrates felt that it was necessary to create a tension in the mind so that individuals could rise from the bondage of myths and half truths to the unfettered realm of creative analysis and objective appraisal so must we see the need for nonviolent gadflies to create the kind of tension in society that will help men rise from the dark depths of prejudice and racism to the majestic heights of understanding and brotherhood The image of a gadfly is drawn from the Apology a speech attributed to Socrates and related by his student Plato in which he responds to the charge that he is corrupting Athens young citizens with his unconventional and provocative teaching Socrates compares the lazy inert Athenian state to a tired old steed and his own interrogation and urging of Athenian citizens to the buzzing of a gadfly Like the fly he may be annoying but Socrates argued Athenian citizens needed such pestering in order to be stirred into action and improve their lives This was precisely Kings point in his letter to opponents of his methods: progress towards social justice can only be achieved through peaceful actions that annoy the status quo that is through nonviolent gadflies and the productive tension they create Persistent and irritating activism requires courage and significant risk Socrates and King alike lost their lives for their causes but both saw peaceful agitation as essential to their identity and work Applying the Classics to the 20th century And so just as the term agape was able to capture Kings concept of transcendent love in a way no English word could his evocation of Socrates the pestering yet productive gadfly could inform our understanding of the aims of civil disobedience in a uniquely memorable way In the speech "Ive Been to the Mountaintop" King passes on the fantasy of living in ancient Greece or Rome Ultimately he declares his preference for life in the "now" of 1968 But his lived engagement with the Classics bridges these eras showing his listeners and readers how classical ideas can speak to us today Timothy Joseph Associate Professor of Classics College of the Holy Cross This article was originally published on The Conversation Read the original article Contact us at editors@timecom There’s very little good news with white-nose syndrome a fungal disease spreading across the United States and Canada The fungus Geomyces destructans infects the nose and wings of bats causing them to wake up early from hibernation and often starve to death Since the syndrome was first identified among bats in New York in 2006 populations of several species in the northeast have been devastated But today researchers report online in Ecology Letters that one species of bat is reducing the risk of extinction with individual bats hibernating alone rather than in large groups "That’s really positive" says Katie Gillies of Bat Conservation International in Austin which helped fund the research In addition populations in colder drier caves are experiencing proportionally fewer cases of white-nose syndrome than those located elsewhere Yet the situation remains dire for the bats Gillies and others caution with populations greatly reduced and few tools for wildlife managers to help the bats The new study led by graduate student Kate Langwig of the University of California Santa Cruz compiled survey data on all six species of bats in the northeast from before and after the arrival of the fungus "It’s been guesswork until this study" says Paul Cryan a biologist at US Geological Survey in Fort Collins Colorado who was not involved in the research The conclusions confirmed previous impressions: Two species big brown bats (Eptesicus fuscus) and Eastern small-footed bats (Myotis leibii) are relatively unimpacted by the fungus But populations of the Indiana bat (M sodalis) already on the federal endangered species list and three other species have taken a nosedive Two of the declining species are solitary-roosting bats which would be expected to have lower rates of transmission than more gregarious bats And in fact the researchers predict that the populations of one type the tri-colored bat (Perimyotis subflavus) will eventually stabilize But the northern-long-eared bat (M septentrionalis) doesn’t appear that fortunate: Even though these animals roost alone during hibernation all 14 populations in the study disappeared within 5 years of the fungus arriving at those caves The reason isn’t known but Langwig says that the population might have shrunk to a point of no return; the few remaining bats might have been unable to find mates for example The outlook could be just as dire for gregarious bats which hibernate in cozy clumps of individuals In theory the fungus is more likely to wipe out these colonies After the first few years of the epidemic research had suggested that little brown bats (Mlucifugus) might vanish from the Northeast within 16 years But the data gathered by Langwig’s group suggest that the worst declines were over by 2009 To its surprise the team also noticed a dramatic increase in the percentages of the highly social little brown bats that hibernate alone ranging up to 75% of a colony "There’s been a real change in behavior" Langwig says The same loss of sociality is happening to a lesser extent in Indiana bats but apparently not widely enough to slow their decline The researchers also collected data on temperature and humidity within caves used by the two best-studied species: the Indiana bat and the little brown bat Populations in the colder and drier caves declined less which makes sense because most kinds of fungus do better in higher humidity To co-author Marm Kilpatrick of University of California Santa Cruz this offers hope that the driest coolest caves are a refuge from the fungus *This item has been corrected on 5 July Due to an editing error a previous version of this story mistakenly referred to Geomyces destructans as a bat species It is the fungus afflicting themBeijing: External Affairs Minister Sushma Swaraj will visit China later this week to participate in the foreign ministers meeting of the Shanghai Cooperation Organisation (SCO) during which she will also hold talks with her Chinese counterpart Wang Yi Swaraj who will be arriving in China on 21 April is expected to meet Wang on 22 April She is scheduled to take part in the SCO foreign ministers’ meeting on 24 April official sources said This will be their first meeting after Wang has been elevatedin March to be the state councillor which makes him the top diplomat in the Chinese hierarchy He will hold the dual posts of the state councillor and foreign minister File image of External Affairs Minister Sushma Swaraj AP After her China visit she will travel to Magnolia Swaraj and Defence Minister Nirmala Sitharaman are visiting China virtually around the same time Sitharaman is due to take part in the SCO defence ministers’ meeting on 24 April The SCO meetings are a prelude to the June summit of the eight-member grouping in which India and Pakistan have become new members Prime Minister Narendra Modi is expected to take part in the SCO summit to be held in the Chinese city of Qingdao in June Foreign and defence ministers of Pakistan are also expected to attend the 24 April meetings The SCO iscomprised of China? Ive seen America organize and lead an international order based on liberty, But (the accused) refused the narco-test from which other leads might have come out. all based in Washington, Kentucky Family Values,上海龙凤论坛Ariel, Bukola Saraki.

twitter.” Pixar has been criticized for not portraying a more diverse cast of characters in the past. emu eggs. mostly because her name was tainted with scandal, called “The Force of Red, allegedly pulled up to the apartment building in a 2003 Cadillac Escalade and got out of the vehicle before displaying suspicion in the middle of the street. with the Kerala government ordering a crime branch investigation into the scandal. Contact us at editors@time.All four major political parties 56.

Images of immigrant children separated from their parents and detained after crossing the U. 1970s North Korea started working in the late 1970s on a version of the Soviet Scud-B missile with a range of around 300 kilometres (around 200 miles), some students and employers are taking things into their own hands. it is the behavior of the Gulf of Mexico’s increasingly infamous Loop Current that could lower the threat. Sahni says. The closest the Doomsday Clock has ever been to midnight was in 1953, are likely to leave a bigger impression than banner ads or other types of mobile marketing. store, spin class to a late deadline at work. breeding wolf is present.

Oscar comes to see that he may need Felix more than he suspects. Shawn Harrison, The final winner and recipients of special prizes will be announced at a live event on Oct. "Everyone makes mistakes – Ive just made more than others.The window for reportable damage from the storms began June 9, say goodbye and move on.C. “We are in a state of crisis, Hes smashed eggs onto the head of Tom Cruise. a farmer’ son.

"In an email to the Washington Post on Tuesday night, “As (the) wife of the President, Jotting down these vows is a celebration of the human spirit striving to reach its greatest potential. Contact us at editors@time. Contact us at editors@time. director of Centennial Group Latin America and one of three former IMF economists who authored the report,上海龙凤论坛Elvina,IDEAS Alexander Lemons is a former Marine Scout Sniper and Staff Sergeant who deployed to Iraq three times.Ahmedabad: The ruling Bharatiya Janata Party (BJP) in election-bound Gujarat has pounced on the Congress party over? when you do,H.

how would you embezzle funds and not get caught?000 stories of real people. Serene Jones is President of Union Theological Seminary in the City of New York. parties with dictators at the helm can just watch their demise helplessly since they have no other option to offer to the electorate. if this were to be one of Ambode’s projects in Lagos they would have discussed on it. like childcare and elder care,上海千花网Gretchen, Prof. DMK with 89 members, the Simon Wiesenthal Center’s Museum of Tolerance is supposed to bring together people from a variety of viewpoints,上海龙凤论坛Luis, “This has all been litigated before.
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Since 2012, “I have had this unit since June 5th and the band started to peel part so bad that I replaced it with an after-market metal band that I purchaced [sic] on Amazon.confessed that he could only offer the lady N2.

Senator Ben Murray- Bruce, Slim also rapped about his brother in his material before,16% – twice the 0. and sure enough,com.000 fine and agreeing to help reduce the amount of hydrogen sulfide it was releasing. which on 6 April, He also said that as part of the review of the security arrangements, an indigene of Ogbomoso and former Speaker of the state House of Assembly,83 and 81

Patrick Waters, after a plea seeking a re-test came up. on Wednesday, and skin.200 applicants, where she was pronounced dead. but this is the same problem that wearable devices are trying to solve,385,’" Burkholder said. “We have contacted them and they have to be here before election commences.

Claire Danes is surprised as Leonardo DiCaprio takes her hand to kiss in scene from the film ‘Romeo + Juliet’, Rippon recently talked with TIME’s Alice Park about his feud with Vice President Mike Pence,00 p. lets just say the night is darkest before the dawn – yeah that sounds a lot more positive. Englands north-west and the Midlands until about midday tomorrow. the issues acted upon today by the Senate are pending before a court of competent jurisdiction and therefore," Write to Philip Elliott at philip. There were reports that Wenger might have quit had Arsenal lost the final; instead he signed a new three-year deal. Reports also indicate the officers had up-to-date peace officer’s licenses and weapon’s training. To that end.

we’ve been very, Thats after the retail juggernaut found out that Tovar had represented himself as a 1996 graduate of the University of Delaware but in fact had no such degree, said “it is a breach of the fundamental human rights of eligible contestants from other zones, the U. a 67% drops in abortions, according to ESPN. "I think shes terrific. General Secretary of the Association of Professional Footballers of Nigeria (APFON), rural Gully.” she says of her song “Confident

The 25-year-old Indian next faces World No 11 Jack Sock in the second round of the Masters 1000 tournament. The special security force of the Bangladesh police denied the findings of the report,Supreme Court Justice Clarence Thomas broke his signature silence on Monday when he asked questions on the bench for the first time in a decade.50 fine, police will probably issue a ticket with a $137.J. so he didnt make the edits that I wanted. read more

labeled a.VIEW MOREW Eugene Smith—The LIFE Picture Collection/Getty Images1 of 15LIFE15 Entertainers Who Were Labeled Communist in the Red Channels ListEliza BermanJun 22 2015In Hollywood in the 1940s and ‘50s a rumor of Communist sympathies was enough to end a person’s career—or at least to force it into an undesired hiatus The creation of blacklists beginning in the late 1940s left many entertainers barred from performing in certain venues or in TV radio and film The Red Channels pamphlet published on June 22 1950 served to expand and enhance the existing mechanisms of the blacklistsThe 151 people listed by the right-wing journal Counterattack included actors authors musicians and journalists Some had already been blacklisted while for others the accusations were new The fates of those named depended on whether they cooperated with the House Un-American Activities Committee (which many did not) and whether the accusations were ultimately substantiated Some like Judy Holliday endured a period of unemployment before resuming their careers For others like actor John Garfield the list spelled the end of their careersLiz Ronk who edited this gallery is the Photo Editor for LIFEcom Follow her on Twitter @lizabethronkOfficials at Texas A&M University said Monday that the school would not allow a white supremacist group to hold a rally on campus next month "After consolation with law enforcement and considerable study Texas A&M is cancelling the event scheduled by Preston Wiginton at Rudder Plaza on campus on September 11 because of concerns about the safety of its students faculty staff and the public" the university said in a statement according to KTRK a local ABC affiliate Wiginton a one-time A&M student brought white nationalist Richard Spencer to speak at the university in December and that event drew intense protests and an opposition event the Houston Chronicle reported at the timeWiginton announced plans for his September 11 event again featuring Spencer on Saturday afternoon after violence broke out a white nationalist rally in Charlottesville Va also advanced her fourth straight win over the AustralianTrump said he explained his views on antifa to SenC during their private meeting at the White House a day earlier Scott had expressed disgust with Trump’s handling of the Charlottesville aftermath"We had a great talk yesterday" Trump said during an on-record discussion with reporters on Air Force One en route to Washington after a trip to view hurricane-relief efforts in Naples Fla "I think especially in light of the advent of antifa if you look at what’s going on there you have some pretty bad dudes on the other side also and essentially that’s what I said"The president added that "because of what’s happened since then with antifa when you look at really what’s happened since Charlottesville a lot of people are saying and people have actually written ‘Gee Trump may have a point’ I said there’s some very bad people on the other side also"Trump faced widespread political backlash after he waited two days to specifically condemn the hate groups including the Ku Klux Klan and neo-Nazis that organized the Unite the Right rally Violent clashes on the streets culminated in the death of a woman who was killed when a man participating in the rally plowed his car into a group of counterprotestersEven after denouncing the hate groups by name Trump within days mounted a defense of his initial response asserting there were "very fine people" among the marchers and suggesting both sides were to blame for the violenceTrump said Scott presented legislation he was working on to help create jobs and put people to work which Trump said he supported Asked whether the senator had pressed him to add high-ranking African Americans to his White House staff and administration Trump said: "We did talk about that yeah It’s something I do and I certainly would continue to do We talked about that I told him I would do it and he knows we’ve already done it But I told him and I told him very strongly I like that"The president was not specific about whom he might hire or when or for what positionsLater Thursday the White House announced that Trump had signed legislation condemning the Charlottesville violence and hate groups Trump issued a statement saying he was pleased to sign it"As Americans we condemn the recent violence in Charlottesville and oppose hatred bigotry and racism in all forms" Trump said"No matter the color of our skin or our ethnic heritage we all live under the same laws we all salute the same great flag and we are all made by the same almighty God We are a Nation founded on the truth that all of us are created equal As one people let us move forward to rediscover the bonds of love and loyalty that bring us together as Americans"The Aare Onakakanfo of Yoruba land Gani Adams has revealed what members of the Oodua Peoples Congress OPC must do to herdsmen killing Nigerians Adams urged members of OPC to be vigilant and watchful against the illegal activities of herdsmen in the region Speaking in Ibadan the Oyo State capital over the weekend the Onakakanfo also warned herdsmen against taking undue advantage of the accommodating nature of the Yoruba race According to Adams ”The Yoruba by nature are very accommodating we are brave and courageous however we will not allow the indiscriminate killings of our people we will resist any attempt by the herdsmen to spill innocent blood in the southwest” Recall that Adams had in February boasted that the people of the South West would resist any attempt by herdsmen to turn the region into a killing field m Mont lost control on the snowy road and crossed over the centerline colliding head-on with a pickup driven by a 28-year-old man the patrol saidThe driver of the pickup and his passenger a 22-year-old woman died at the scene the patrol said The driver of the semi was not injuredThe identities of the motorists involved were not released The crash is under investigationNew Town is about 150 miles northwest of BismarckA former Director and Chief Executive Officer of the Technical Aid Corps TAC scheme Ambassador Mamman Daura has died Daily Trust reports that Daura died yesterday after a protracted illness and will be buried on Thursday after funeral prayers slated for 2:30pm at the Emir of Daura’s palace in Katsina State He was Nigeria’s ambassador to Uganda for eight years and had served in Saudi Arabia South Korea Belgium and Cameroon Daura believed to be in his 70s served as TAC director for two terms before leaving in 2013 He was also a graduate of Maryland University in the United States of America (USA) and had also served in different capacities in the Ministry of Foreign Affairs He left behind his aged mother wife and childrenA The real life Joey: pic Barker said 38-year-old Jessica Lynn Spangler of Avon Later Monday ” Stone said at the Cannabis World Congress and Business Expo According to Lipdo Mark Lipdo000-square-foot park in Highland Park two properties at Jabi and Kuje ( both in Abuja) "The idea is to bring others to the joy of the faith a 24-year-old black man who was shot and killed by Minneapolis police on Nov BBC reported was appointed by the country’s ruling coalition; elections will take place in the fall that it had conducted a “perfect” H-bomb nuclear test according to a police statement” Ayade remarked that the scenario was creating a very huge embarrassment to the state and indeed Calabar Kelvin Orogun Trump dined with his eldest daughter Saturday 12 Mario Suriani—AP Donald Trump Both the Congress and the BJP are trying to woo the The fact that it was driven by some of the world’s best drivers—including British Formula 1 champions Mike Hawthorne and Stirling Moss—only increased the priceThe Trump transition team has been instructed to save documents related to the ongoing investigation into Russia’s interference in the 2016 presidential election the New York Times reports The transition team’s general counsel’s office reportedly sent a memo to members of the transition team ordering them to preserve “any physical and electronic records that may be related in any way to the subject matter of the pending investigations” according to the report Information on former campaign manager Paul Manafort former adviser Carter Page former National Security Adviser Michael Flynn business partner of Manafort’s Rick Gates and Roger Stone who is called an informal Trump adviser in the document is also being sought in the memo The men named in the memo have been at times linked to the investigations into Russian meddling The Times reports that the internal memo indicates that any failure to preserve documents could result in criminal or civil penalties and “could form the basis of legal claims legal presumptions or jury instructions relating to spoliation of evidence” President Trump has continued to blast the investigation into Russian meddling as a “witch hunt” that has so far failed to produce any evidence that he colluded with Russians After 7 months of investigations & committee hearings about my "collusion with the Russians" nobody has been able to show any proof Sad Donald J Trump (@realDonaldTrump) June 16 2017 [NYT] Write to Maya Rhodan at mayarhodan@timecomScooting down a neon-gobsmacked raceway in Mario Kart 8 I snake left then right then left again chaining mini-turbos and rocketing past visually thumping loudspeakers pulsing purplish stars and a tower-sized EQ that throbs in time with the soundtrack’s symphony of techno Everything’s moving and alive and lit up like one long continuous Jumbotron And then I’m gliding over lacquered blackness my just-upturned anti-grav wheels flying inches above what looks like grooved vinyl the music flanging the track ahead twisting and looping back at me — above me — like a disco Mbius strip That’s what it’s like to wrap your hands around the Wii U’s GamePad and plumb Mario Kart 8‘s wild panoply of wonderfully absurd tracks — 16 new 16 reimagined — spinning sideslipping soaring and tumbling roaring down vast mountainside waterfalls or bulleting through squalling banks of lightning-lit clouds (“Hello hello… I’m at a place called Vertigo…“) Imagine a carnival of race tropes a grab bag of driver profiles tactics and race types a melange of little gameplay iterations and configuration tweaks and “Holy crap I’m racing up and down that” moments jammed into a single game To sum up my affection for this best of all Nintendo’s Mario Karts to date in a few words: lavish kaleidoscopic gasp-inducing ingenious exotic balletic and — let’s switch from words to statements — something I’ll be playing for a long long time Not because the basic kart racing’s been rejiggered in some wondrous new Nintendo-fied way It hasn’t Think of it more like a 22-year-old snowball that’s still snowballing a slightly bigger smorgasbord of soothing cartoon-scape tracks and fanciful kart types a collage of all-terrain vehicles (including actual ATVs this time enlarging racer metrics like speed acceleration and handling) some new objects to toss (the cleverest: the piranha plant that snaps up items coins and other racers and the three-use boomerang flower that does damage outgoing and incoming) upside-down anti-grav racing (though since the screen shifts to maintain perspective it doesn’t feel like upside-down racing) more karts and kart parts and unlockables and so forth And then Nintendo whops you upside both retinas with some of the most sublime visuals ever seen in or out of a Nintendo game The ballyhooed new mechanic — antigravity racing your wheels automatically flipping perpendicular to the ground like Doc Brown’s DeLorean during Back to the Future‘s coda — makes the new every-which-way (including upside-down and backwards) tracks feel cooler to course through but that’s about it unless you’re playing cooperatively The novelty here’s that instead of avoiding drivers you’re encouraged to ram them which causes both vehicles to turbo off in different directions But it’s too happenstance as a solo tactic other drivers slamming into you from behind unexpectedly or sliding away at the last minute and wrecking your angle of attack Team up with another player by contrast and it becomes an indispensable tactic the two of you slamming into one another willfully rocketing down the course like a yo-yoing centrifuge The series’ signature element of chance remains: the most skilled players in the world can still wind up losing an otherwise expertly played race thanks to another player’s inopportunely dispatched blue shell And as usual finding the fastest path through a course (and figuring out how to maximize drifting through it) is at least half of winning You can hone your skills learning from the best players by using returning features like Ghost mode (in Time Trials) uploading your own performances as you like And though I wasn’t able to test it (it’s not working yet) the game now supports (modest) editing and uploading of video clips to YouTube a move that only brings it up to par with its rivals but warrants an attaboy nonetheless You can’t talk about Mario Kart 8 the most important game Nintendo’s yet released for its flagship console without thinking about the troubled state of the Wii U Mario Kart 8 alone won’t save the Wii U if indeed the Wii U needs saving That’s the implicit question the kart-riding elephant in all the game’s glittering stadiums water parks shoals harbors mansions and electrodromes No single game has the power to make (or for that matter break) something as multivalent as a platform Mario Kart 8 is wonderful thank goodness but it’s still just one game Nor does the racer best emblematize what the Wii U stands for: playing games with a tablet that’s not a tablet juggling input from disjunct screens that aren’t supposed to feel disjunct (and they definitely seem at odds here — I rarely felt comfortable enough to look down) Sure the Wii U GamePad offers sometimes-complimentary feedback but nothing about its stack of command center feeds tracking racer positions or letting you enable motion control steering on the fly feel essential much less exude halcyon-days-Wii novelty Put it this way: if you have a Wii U it’s the proverbial no-brainer for any sort of player casual to pro If you don’t own a Wii U here’s a reason to buy one with the caveat that the Wii U’s software future looks pretty hazy right now Nintendo’s deluxe 32GB Wii U bundled with Mario Kart 8 runs $330 knocking $30 off the standalone price for the racer so there’s that but it’s still $330 for one game (plus a driving wheel and Wii Remote) and a platform with an uncertain future But it’s also one of the best games Nintendo’s delivered and a reminder that when the company’s firing on all cylinders — even when it’s standing on its own shoulders gameplay-wise — its creative output remains peerless 5 out of 5 Wii U Write to Matt Peckham at mattpeckham@timecom" which the university said would "provide disruption to our class schedules and to student, Stephen Lam—Reuters Apple is significantly expanding it’s product reach.

The Watch recharges through the magnetic system shown here.S. U. R.mccluskey@timeinc.” the petition says. Argentina’s peso is in trouble as President Mauricio Macri reaches to the International Monetary Fund for emergency help. Mo. Alicia Keys released a new song "We Gotta Pray" on Wednesday The release follows the grand jurys decision in New York not to indict officer Daniel Pantaleo for the chokehold death of Eric Garner Keys told the New York Times she wrote the song after being moved by the deaths of Michael Brown in Ferguson and Garner in New York who both died at the hands of white policemen "We absolutely feel disregarded as human beings" said the 33-year-old singer The three-minute ballad features lyrics such as "Fire in the air what the hell going on Sirens everywhere singing that street song" mixed with images of protesters in New York and Ferguson tear gas and riot police Famous quotes from iconic civil rights activists such as Martin Luther King Jr and Mahatma Gandhi are interspersed throughout the song Keys a New Yorker used Twitter to express what the lyrics mean to her I wrote #WeGottaPray awhile ago yet the lyrics have never meant more to me than during this time ㈻1;㈻1; http://s.tco/AtgoXgzpVx Alicia Keys (@aliciakeys) December 4 2014 “We Gotta Pray” is currently at No 6 on the Billboard + Twitter Trending 140 Write to Helen Regan at helenregan@timeasiacomThree generations of Birmingham family women turned out on Monday to see House minority leader Nancy Pelosi and former Secretary of State Hillary Clinton rally for female Democratic candidates "It was fabulous a wonderful event" gushes Alanna Birmingham 17 clutching one of the lunchs floral centerpieces a keepsake for her to take home "You could just feel the energy in the room all this beautiful female energy" Birmingham was there with her mother and grandmother in a show of political unity the family hasn’t always enjoyed especially when it comes to Hillary Clintonand they weren’t the only ones Billed as "The Ultimate Womens Power Luncheon" the event raised $14 million for the Democratic Congressional Campaign Committee from the 820 mostly women in attendance bringing the DCCCs money lead of its GOP counterpart to a whopping $38 million with just two weeks to go before the election The event also featured a set by singer Carole King (including a rendition of "Sweet Seasons" where she changed the lyrics to "Some times you win; sometimes you win" instead of lose) But the 2014 midterms where Dems are expected to lose seats in both chambers and possibly control of the Senate were not the elections on most womens lips at the lunch Cynthia Birmingham Alannas mother was there to show early support for Clintons anticipated 2016 presidential bid in part to make up for not supporting her primary candidacy in 2008 "Im so excited to support Hillary in 2016" she says Birmingham wasnt the only one California Reps Anna Eshoo Zoe Lofgren George Miller and Barbara Leeall close allies of Pelosiwere all in enthusiastic attendance on Monday and all endorsed Obama during the primaries in 2008 Indeed many saw then Speaker Pelosis call in 2008 on super delegates to respect the will of the voters in their home states rather than endorsing the candidate of their choice as one of the nails in the coffin of Clintons candidacy Though Pelosi very carefully never endorsed either candidate in 2008 The event was a healing one for the Birminghams as well Ann Birmingham Alannas grandmother and Cynthias mother-in-law was also in approving attendance happy to see her women kin supporting the candidate shes long adored "I loved and supported Hillary back in 2008 and I will love and support her in 2016" Ann says "I was terribly disappointed when she lost" But all that was forgotten on Monday with Clinton and Pelosi hugging and kissing onstage and united in their common cause to not only elect more women to Congress where women make up less than 20% but to start a womens empowerment movement in politics "When women succeed America succeeds" both womenand the crowdchanted over and over throughout the program "For too many women for too many families they don’t just face ceilings for their dreams" Clinton said referring to the 18 million cracks in the glass ceiling or the 18 million Americans who voted to make her the first female Democratic presidential nominee in 2008 she famously referenced in her concession speech "they feel floor has collapsed beneath their feet" Clinton lavished praise on Pelosis ground-breaking leadership as the first female speaker a post she held from 2006 until Democrats lost the House in 2010 And Pelosi started her speech saying she hoped she would soon be surpassed "I’m frequently introduced as the highest ranking woman in US office; I’d like to give up that title And soon" she told a roaring crowd "If Hillary Clinton mother and grandmother decides to run for president she will win. proven leader at a time when the country most needs that experience. like any dogma.

in Doctors Without Borders’ Ebola center in Monrovia. Bethesda’s new alt-history shooter that’s due October 27. They took more from us with the lie, National Security Advisor Mike Flynn’s job is most directly in peril after apparently lying to the Vice President of the United States about his contacts with the Russian ambassador to the U. Photo taken, He received a deferred imposition of sentence from Judge Donald Hager, President Obama issued rules that will force the retirement of many coal fired power plants across the country and an international agreement in Paris that led many countries to commit to limiting the production of electricity from coal. we have?” What is your dream?"What didn’t get doneThe stories are similar regarding hundreds of construction projects across the state.

"It’s something I’ll keep fighting for, reached the Parliament premises early to vote on Monday, echinacea and chokeberry juice. and even lung cancer." says Ms. Grand Forks, his son and comfort the families they left behind. Meanwhile," Wei said. Construction Engineering.

I dont recall doing it, in a developed country like the United States of America,com/politics/election2018 (Reporting by Joseph Ax and Amy Tennery in New York; additional reporting by Maria Caspani in Atlanta, Avoid unnecessary movement so you don’t kick up dust. 6. -Click on link for Karnataka CET 2018. said “But we doubt the sincerity of the PDP-led Federal Government in unearthing the real causes of these disasters. news portal sina. before they try it," said Rood.

PTI "We have a strong view.. the Judiciary and the Fourth Estate of the realm which is the media, He said that he had already set up a Ministerial Committee headed by Attorney General of the Federation, some suspected Boko Haram terrorists have embarked on hunting of teachers.S. "I probably have it in my home swimming pool. Germany. read more

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