first_img17Jan Rep. VanderWall attends State of the State Categories: VanderWall News,VanderWall Photos State Rep. Curt VanderWall, R-Ludington, is joined by his wife, Diane, to listen to the governor’s State of the State address on the House floor on Tuesday evening.###last_img

first_img15Mar Rep. Hauck bill addressing drone use passes House committee vote The House Committee on Communications and Technology this week advanced a bill proposed by state Rep. Roger Hauck of Union Township as part of a larger legislative package establishing needed state guidelines for drones.Hauck’s bill, House Bill 5495, highlights facilities where use of unmanned aircraft systems will be prohibited under state law. The language refers to knowingly and intentionally interfering with “key facilities” as defined in the Michigan Penal Code, including manufacturing plants, electric or natural gas utilities, correctional sites and telecommunication facilities. Companion legislation sponsored by state Rep. Jim Lower of Cedar Lake offers a sentencing guideline making intentional drone interference with a key facility up to a four-year felony.“Over time, improved education will lead to more educated use,” Hauck said. “My bill allows for a lot of prosecutor discretion because of how new this technology is. Knowledge and intent will be two big things within that discretion. A surveyor who flies a drone over a highway or high voltage power line may not know that he is breaking a law. This proposal improves safety, offers clear deterrents for bad actors, grants leeway for hobbyists and puts rules on the books that can be better recognized and accepted the longer we have this technology.”A 2016 Federal Aviation Administration report estimated 2.5 million drones were being operated nationwide for a variety of purposes, including hobbyist and commercial. That number could grow to a projected 7 million by 2020.A 27-member Unmanned Aircraft Systems Task Force, appointed by Gov. Rick Snyder, began work in April 2017 to develop statewide recommendations on the operation, use and regulation of unmanned aircraft in Michigan. The bills offered largely reflect the task force’s policy recommendations.“There needs to be some definition here where the letter of the law could be clearly identified regarding drone usage,” Hauck said. “There are a lot of hobbyists and recreational drone users and not a lot of education or information on where you can and can’t use them.”The bills within the package, HBs 5494-98, advance to the House floor for further consideration.PHOTO INFORMATION: State Rep. Roger Hauck, of Union Township, provides testimony in support of House Bill 5495 before the House Committee on Communications and Technology on Feb. 13. Hauck’s legislation is part of a bill package aiming to regulate unmanned aircraft at the state level. Categories: Hauck News,Newslast_img read more

first_imgSocial networks’ share of advertising spend in the UK will overtake television ad spend by 2020, according to stats published by eMarketer.The research firm said that come 2020, social network ad spending will account for 20% of all media ad spend in the UK, compared to 17.8% for broadcast TV.As it stands today, social networks’ share of ad spending has overtaken all traditional media formats in the UK, with the exception of TV, and is expected to grow throughout the year.eMarketer estimates that marketers in the UK will spend £3.3 billion on social network advertising in 2018, a 24% increase over 2017.It has also increased its social ad projections since its previous forecast due to diversification in the marketplace, which it says is driving up overall social network user rates and resulting in increased spend.“While Facebook has been losing teen users, Snapchat has been adding them,” said Bill Fisher, eMarketer’s UK senior analyst.“The result is a growing social media market, and one that advertisers are keen to utilise. Media-rich targeting options, with video a particularly big play, make platforms like Snapchat and Instagram especially attractive.”last_img read more

first_img“We are on the cusp of curing aging.” Those are the words of molecular biologist Dr. William Andrews, founder and CEO of Sierra Sciences, a company with the stated goal to “cure aging or die trying.” In the quote above, which comes from a September 2010 Sierra Sciences press release, Andrews is referring to a nutraceutical (i.e., a natural food-derived product meant to provide health or medical benefits, like vitamin C or folic acid) that his company discovered, known as TA-65. It supposedly slows down the aging process in humans by activating an enzyme called telomerase. Telomerase acts on telomeres—simple repeating sequences of nucleotides (the building blocks of DNA) found at the tips of chromosomes that are important to cell division and replication. Cells must replicate their genes accurately and completely whenever they divide, or the so-called daughter cell will malfunction and die. However, most DNA polymerases (the enzymes that replicate DNA) cannot copy chromosomes all the way to the end. Thus, during each cell division, a small region at the tip of the chromosome (part of the telomere) remains uncopied. So, the telomeres have a crucial function: they act as a buffer zone during cell division, protecting the genes in the chromosome and ensuring that they fully replicate. But there’s a cost: successive divisions cause the telomeres to erode over time. When telomeres erode away, parts of critical genes remain uncopied, eventually spelling death for the cell. Some scientists think that this telomere erosion is what imposes a limit on our lifespans and causes our health to decline as we age; they also think that an answer to this dilemma might be telomerase activation. Telomerase combats telomere erosion by adding telomeric subunits (repeating sequences of nucleotides) to the ends of the chromosome, thereby allowing it to continue to divide intact. The origin of telomerase still remains a mystery. It appears to be critical during human embryonic development, but then fades away. Little is found in the body after birth, for reasons we don’t yet understand. Some scientists, like Dr. Andrews, think telomerase activation could be the cure for aging that his company is looking for, and he views TA-65 as a potential big first step in that direction. According to Andrews: TA-65 is going to go down in history as the first supplement you can take that doesn’t merely extend your life a few years by improving your health, but actually affects the underlying mechanisms of aging. Better telomerase inducers will be developed in the coming years, but TA-65 is the first of a whole new family of telomerase-activating therapies that could eventually keep us young and healthy forever. Well, if proven true, that’s a game-changer, to say the least. Just keep on living until you meet with a fatal accident. Woo hoo! But… hold on. Turns out we shouldn’t get irrationally exuberant just yet. It might not be such a good idea to activate telomerase, after all—because of the role it seems to play in cancer. Cancers can arise when genetic mutations inside a cell cause it to escape from normal controls on replication and migration. The cell and its offspring multiply uncontrollably while invading and damaging nearby tissue. With the presence of telomerase, cancerous cells—which apparently synthesize the enzyme—avoid telomere erosion. They essentially become immortal, dividing for as long as the host survives. A 2012 study by the MD Anderson Cancer Center found that activating telomerase following telomere degradation actually made tumors stronger and more deadly. So alas, TA-65 and telomerase activation might not be the miracle aging “cure” Dr. Andrews was hoping for. But what about other areas of anti-aging/longevity research? There’s a lot of talk these days about humans becoming essentially immortal in the near future, but is the hype supported by any actual research? Let’s see. The Quest for Immortality Continues People have been obsessed with the idea of immortality and living forever for centuries. According to Adam Gollner in The Book of Immortality: The Science, Belief, and Magic Behind Living Forever: The twenty-five-year old Emperor Ai of Jin died in 365 CE, after overdosing on longevity drugs. He wasn’t the last leader to die trying to live forever. The fascination with chemical immortality reached an ironic apogee centuries later, during the T’ang dynasty (618-907 CE), when elixirs poisoned those hoping for precisely the opposite effect. In the late 1300s, legend has it that alchemist Nicolas Flamel created a “sorcerer’s stone” that was then used to produce a potion, the elixir of life, which is said to make the drinker immortal. The idea was so alluring that despite a complete lack of evidence to support the existence of the stone and the elixir, other scientists, including the great Sir Isaac Newton, later tried to replicate Flamel’s results. To no avail. And of course there’s the fabled Fountain of Youth that became associated with Spanish explorer Ponce de León in the early 1500s. We know what happened to him. People today are no different. Not wanting to die is as natural as life itself. Below we’ll present a few interesting discoveries that may (or may not) mark some progress in our quest to live forever. But first we must answer a question. What Is Anti-Aging Medicine? The telomere erosion we talked about earlier certainly plays a part in aging, but most scientists don’t believe that it’s the only factor. They typically view aging as a sort of ongoing cellular wear and tear, where stresses from the environment and inside our cells (such as errors in DNA replication) accumulate throughout life and eventually wear out our cells and tissues. Scientists who search for a modern anti-aging elixir seek to slow down or reverse this process in order to extend both the maximum and average lifespan of people. And even if that doesn’t pan out, advocates of anti-aging medicine contend that at the least, targeting and altering the underlying mechanisms of aging will bring us more efficient ways to deal with age-related conditions like heart disease and many cancers. Now critics dispute the portrayal of aging itself as a disease, of course, but that’s not for us to debate here. Let’s just agree with the commonly stated goal of anti-aging medicine, to “add more years to your life, and life to your years.” Caloric Restriction Mimetics In 1934, scientists at Cornell University found that mice on an abnormally low-calorie diet lived about twice as long as mice who ate as much as they wanted. Scientists have since found that this caloric restriction also lengthens the lives of fruit flies, rats, and even primates, suggesting that this is an avenue worth pursuing in anti-aging medicine. The going (very basic) hypothesis of why these animals live longer is that their bodies treat food scarcity as an extreme type of stress. So they mount a physiological response to cope with the lack of nutrition. And that toughens them up, promoting health and longevity during the time of deprivation, even if that time is significantly extended. Starving yourself in order to get stronger? That sure seems counterintuitive. But the results from numerous experiments make a compelling case. The problem with caloric restriction is that it’s not a very pleasant way to live if you’re fortunate enough to be able to consume a “normal” amount of food on a regular basis (which is between 2,400 and 3,000 calories a day for active males). So scientists are trying to develop drugs (called caloric restriction mimetic drugs) that re-create the anti-aging benefits of caloric restriction without having to change one’s diet. Resveratrol, which is found in the skin of red grapes, was an early favorite in this category. It was first thought to activate a class of enzymes called sirtuins that have been associated with the anti-aging benefits of caloric restriction; but more recent studies have raised serious doubts about whether this compound (and more potent versions of it) actually activates these enzymes and has life-extending benefits. A drug called rapamycin has shown more promise as a caloric restriction mimetic by inhibiting a molecular signaling pathway called TOR. The TOR pathway acts as sort of as a food sensor and helps regulate the body’s response to nutrient availability. Blocking it has been shown on multiple occasions to extend the lifespan of lab knockout mice while keeping them lean and healthy in their later years. Unfortunately, however, the drug’s anti-aging potential in humans is offset by its potent immunosuppressant effects. Overall, research in this field has a long way to go. NAD As we noted above, aging is a sort of cellular wear and tear. According to Dr. David Sinclair of Harvard Medical School, there’s a specific biological signal that accompanies aging and tells cells it’s time to check out. It’s triggered when the cell perceives a lack of oxygen. That makes the mitochondria less efficient at converting fuel (such as glucose) into the ATP needed for cells to function properly. But Sinclair and his colleagues recently found a way to counteract that signal. Using a natural chemical compound called NAD, they were able to revive older cells in mice and make them appear energetic and young again. After receiving NAD for just one week, two-year-old mice tissue came to resemble that of six-month-old mice. “When we give the molecule, the cells think oxygen levels are normal and everything revs back up again,” Sinclair explained. “If a body is slowly falling apart and losing the ability to regulate itself effectively, we can get it back on track to what it was in its 20s and 30s.” Let’s hope. FOXO Molecular biologist Cynthia Kenyon thinks she may have found another of the keys to a long life through her study of tiny worms called C. elegans. By tweaking just one gene in these worms (to simply make it more active), she was able to take two-week-old C. elegans (which is a creaky old age for these things) and make them appear about half that age. And her modified worms lived twice as long as the normal worms. “So they’re like 90-year-old people who look 45,” said Kenyon. The gene Kenyon changed: FOXO. FOXO is a sort of master gene that helps C. elegans protect and repair its tissues (and live longer) by controlling a number of other genes. According to Kenyon: You can think of it as a superintendent of a building. So if you have a building, a nice big building, obviously it has to be maintained. What FOXO does, or the building superintendent does, is to keep the building in good working order. It makes sure that the walls are painted, by hiring painters; it makes sure that the floors are swept. The building superintendent would hire workers to do these different things. What FOXO does, in the cell, is it switches on other genes … I’d say, altogether, there are probably about a hundred worker genes that have very important roles. And, together, what you get is a cell or tissue or an animal that stays in really good working condition for a lot longer. What’s particularly exciting about Kenyon’s work is that the FOXO gene is also found in humans, and that a more protective version of FOXO (as in Kenyon’s modified worms) is associated with longer, healthier lives. Molecular biologist Timothy Donlon found in his studies that if you have this more protective version of FOXO, you have a twofold greater chance of living to 100. And if you have two copies of it, you have a threefold greater chance of living to 100, while remaining healthy. So the gene is indeed associated with adding life to your years and years to your life. If scientists could create a drug to tweak FOXO in humans like Kenyon did in her worms, it seems like we’d have an effective anti-aging medicine on our hands. We could go on with other examples of promising research in anti-aging medicine, but that’s a reasonable sample. It’s the ultimate area of scientific research, really. Moreover, it seems likely to bring benefits to humankind (and also be lucrative for savvy investors) whether aging is a disease that can be “cured” or not. And before leaving you today, I do want to remind you once more about the opportunity to get in on Casey OnePass. It’s just open until Monday, and it’s your only chance to get all eight of our newsletters for a huge discount. Click here to learn more and get started.last_img read more

first_img Staff Writer. Covers leadership, media, technology and culture. The only list that measures privately-held company performance across multiple dimensions—not just revenue. This article is included in Entrepreneur Voices on Company Culture, a new book containing insights from more than 20 contributors, entrepreneurs, and thought leaders.During a Tuesday meeting to discuss an overhaul of Uber’s company culture, former board member David Bonderman proved exactly why the conversations needed to happen in the first place.At the start of the all-hands meeting, Arianna Huffington, who was the first woman to join the company’s board last year, announced the addition of Nestlé executive Wan Ling Martello to the board, increasing the representation of women on the board from 14 to 25 percent.“There’s a lot of data that shows when there’s one woman on the board, it’s much more likely that there will be a second woman on the board,” Huffington noted.That’s when Bonderman interrupted.“Actually what it shows is it’s much likely to be more talking.”In the recording obtained by Yahoo Finance, you can hear Huffington respond at first with awkward laughter. And then her reply: “Oh. Come on, David. Don’t worry, David will have a lot more talking to do as well.”That is not to be the case, as Bonderman resigned shortly after the meeting, which, it bears repeating, was convened to talk about recommendations to change Uber’s culture after allegations of systemic discrimination and sexual harassment.Related: 3 Lessons Every CEO Can Learn From Travis Kalanick’s Emotional Meeting With Uber’s Female EngineersBonderman, the 74-year-old founding partner of investment firm TPG Capital, apologized for the “disrespectful” comment via an internal memo to Uber employees and issued this statement about his departure:”I do not want my comments to create distraction as Uber works to build a culture of which we can be proud. I need to hold myself to the same standards that we’re asking Uber to adopt. Therefore, I have decided to resign from Uber’s board of directors, effective tomorrow morning.”Earlier on Tuesday, CEO Travis Kalanick also announced that he would be taking a leave of absence in order to, as he shared in an email to the company, “take some time off of the day-to-day to grieve my mother, whom I buried on Friday, to reflect, to work on myself, and to focus on building out a world-class leadership team. The ultimate responsibility, for where we’ve gotten and how we’ve gotten here rests on my shoulders,” Kalanick wrote. “There is of course much to be proud of but there is much to improve. For Uber 2.0 to succeed there is nothing more important than dedicating my time to building out the leadership team. But if we are going to work on Uber 2.0, I also need to work on Travis 2.0 to become the leader that this company needs and that you deserve.”Related: Travis Kalanick to Take a Leave of Absence. Here Are 9 CEOs Who Were Fired or Decided to Step Down.So what exactly is Uber 2.0 going to look like?Over the past few months, former attorney general Eric Holder and Tammy Albarrán, partners at law firm Covington & Burling, were tasked with investigating the allegations made by former engineer Susan Fowler and others.They interviewed more than 200 Uber employees and provided a set of recommendations pertaining to how the company should address discrimination, harassment and retaliation and how it could “ensure that its commitment to a diverse and inclusive workplace was reflected not only in the company’s policies but made real in the experiences of each of Uber’s employees.”The recommendations include:Providing more support for the human resources department and establishing clear protocols to track complaints.Mandatory training for senior executives, HR staffers, managers and people in the position to interview prospective employees, particularly around the topics of promoting inclusion and combatting unconscious bias.In terms of recruiting and developing talent, implementing a blind resume review, and increased transparency when it comes to performance reviews and promotions.The prohibition of romantic or intimate relationships between supervisor/subordinates and the consumption of alcohol during work hours, at after work events and at company-sponsored events.An update of discrimination and harassment policies including instituting a zero-tolerance policy for violators of those rules — no matter what position they hold in the company — and explicit protection against harassment from not only other employees, but third-parties the company deals with such as clients to vendors.Related: A 2013 Letter From Uber’s Travis Kalanick Lays Out Sex Rules for Employees at Company PartyA lot of these seem quite standard. But when you look at former engineer Susan Fowler’s blog post and Kalanick’s 2013 Miami letter side by side, the necessity for Holder and Albarrán to explicitly state things such as the importance of “de-emphasizing alcohol as a component of work events,” or that policies should be applied consistently across the company with no special treatment afforded to any one employee is pretty glaring.One passage in particular about Uber’s 14 cultural values speaks volumes about where Uber ran aground. Holder and Albarrán recommended that the company communicate with its employees to reassess and develop a core list of values that are accessible and easy to understand.  “Eliminate those values which have been identified as redundant or as having been used to justify poor behavior, including Let Builders Build, Always Be Hustlin’, Meritocracy and Toe-Stepping, and Principled Confrontation; and encourage senior leaders to exhibit the values on a daily basis and to model a more collaborative and inclusive Uber culture,” the recommendation reads. “Leaders who embody these values should be part of the process of redefining Uber’s values and should be role models for other leaders within the company.”Related: Uber CEO Travis Kalanick Says He Needs to ‘Grow Up’ After Video of Argument With a Driver ReleasedUber has long had a reputation for aggressive tactics in its dealings with regulators and competitors. It was seen, for better or worse, as one of the key drivers of its rapid growth. But clearly, as Uber’s experience shows us, growth and success are not one in the same.In an interview with Vanity Fair in 2014, Kara Swisher asked Kalanick about the nature of the interactions with the leaders of the cities (some of whom he described as “really awesome, but most are uninspired”) his business was disrupting.“If you don’t agree with the core principles, which are the premise of that compromise, then you have to have what I call principled confrontation. And so that is the thing that we do that I think can rub some people the wrong way.”If you’re beginning with the premise that compromise doesn’t work for you, and every interaction is a war of attrition, you can let people build all they want, but what exactly are you working toward?If you’re always hustlin’ — though if they do keep that one, I would urge them to restore the “g” to its rightful place — you don’t stop to think about where the pitfalls may be or whether you might be in the wrong. Uber’s experience shows us that is kind of approach is a recipe for collapsing under the weight of your own hubris.Related: If Elon Musk Can Admit His Mistakes, Then So Can YouIn Uber’s San Francisco headquarters, up until this week, the office’s main conference room was called aptly, the War Room. Bloomberg reported that along with the multitude of changes recommended by Covington & Burling, the room is now going to be called the Peace Room. It’s a bit on nose, but you can appreciate the thought, as long as it’s not just lip service.Uber’s culture is not going to change overnight, but now the company seems to have the self-awareness and tools in place to build an environment where values aren’t used, as per Holder and Albarrán’s description, to “justify poor behavior.”So what can we learn from Uber’s newfound emphasis on internal, rather than external growth? Company culture isn’t about perks or empty aphorisms that look good on a T-shirt. Simply, people want to be heard, they want their work to be valued and they want to be treated with respect. When you build your company culture, start there. Entrepreneur Staff 82shares Nina Zipkin Image credit: Spencer Platt | Getty Images 2019 Entrepreneur 360 List Apply Now »center_img Uber June 15, 2017 Uber Needs to Recreate its Company Culture. Here’s What You Can Learn From Its Mistakes. Add to Queue Start by treating people with respect. It’s as simple as that. 8 min read Next Article last_img read more

first_img Next Article February 12, 2009 Technology The only list that measures privately-held company performance across multiple dimensions—not just revenue. Ustream.TVFounders/ages: Gyula Feher, 30; John Ham, 30; Brad Hunstable, 30Launched: 2007App: A destination platform for streaming live video over the internet; includes co-hosting, chat and hyperlink overlay functionsWhy it works: While YouTube hosts previously recorded videos, Ustream hosts live content, allowing real-time viewing and interaction.Just UptimeFounder/age: Chris Phillips, 25Launched: June 2008App: A website- and server-monitoring application that provides instant e-mail notifications, SMS text alerts and detailed reporting when your website or server is downWhy it works: Sure, a few people out there spend every waking moment online. But for those who don’t, this intuitive app gives them a heads up when issues arise.OoVooCEO/age: Philippe Schwartz, 44Launched: 2007App: An innovative video service for creating video messages, real-time video chats for up to six people and live video callsWhy it works: Communication, whether between friends and family or employees and business partners, has moved online. OoVoo allows face-to-face conversations when being in the same room isn’t possible. Lindsay Holloway Apply Now » This story appears in the March 2009 issue of Entrepreneur. Subscribe » If you’re thinking about creating a web app–whether as a business or to use in your existing business–its construction costs and time can run the gamut. It depends on many factors: how complicated the technology is, what tools you use to build it and so on. But details aside, here are a few web app entrepreneurs who show us it can be done.Iotum CalliflowerFounders/ages: Alec Saunders, 45; Howard Thaw, 52Launched: June 2008App: A meeting tool that bridges businesses and social networks to allow the planning of and participation in interactive conference callsWhy it works: The solution is all-encompassing: It combines high-quality audio conferencing, scheduling, file sharing and collaboration in an easy-to-use interface.MedAppsFounder/age: Kent E. Dicks, 48Launched: 2005App: A two-part application that provides a remote health-monitoring solution; the mobile app collects patient data and readings that a health-care professional monitors via the web appWhy it works: MedApps makes remote health monitoring accessible and inexpensive to the more than 133 million people in the U.S. with at least one chronic condition. Magazine Contributor Yes, You Can Build Your Own Web App 2019 Entrepreneur 360 List Get started nowInspired to build your own web app? These sites can help you take that first step. –shares 2 min read Add to Queue Caspio Coghead Intuit QuickBase Zoho Creatorlast_img read more

first_img Your reaction to particularly awful days can make or break future success. The better action to take is to remain as calm as possible. Take quiet time to analyze how far you have come. Think about the twists and turns, and what currently has you stopped in your tracks.Numerous conversations revealed that many almost quit their current endeavors. But one common factor as to why they did not quit helped them to prevail: They enjoy what they do too much! Ironically, it has become their way of life.As uncertainty hits, follow these two suggestions:Take the time needed to uncover the better route.Convert a negative frame of mind into a positive.Reframe the situationOne sales technique referred to as “Reframing” applies very well to difficult situations. Whether personal or trying to work with a client, the first step is to figure out where the discontent originates. Upon recognizing the misstep, it becomes easier to work together to find the better solution. By asking a series of questions such as, “What if…” the improved path begins to reveal itself.On the personal side, moving from negative to positive thought is the beginning step for improvement. The change in attitude makes an enormous difference in providing increased opportunity to save the day.The day that you find you are doubting yourself, take private time to consider “the why” that is. Most likely, one of your peers will have had a similar experience. Have a conversation about how they dealt with it and ask for recommendations on how to handle. Their insights won’t necessarily apply or even matter. It’s more about the conversation itself. Just by unleashing the dilemma is all it takes to get back to full steam ahead.  As others see you meeting negativity and obstacles head on, they come to admire your steadfast personal brand.Tips:When negativity hits, stop to examine the origin.Decide whether changes need to be made.Should changes be in order, decide whether they are minor or major.Begin the process by eliminating the no longer needed.Create a list of what needs to be fixed.Prioritize the list in order of immediate need.Re-energize yourself and/or business by communicating. –shares Image credit: Shutterstock Fireside Chat | July 25: Three Surprising Ways to Build Your Brand Learn from renowned serial entrepreneur David Meltzer how to find your frequency in order to stand out from your competitors and build a brand that is authentic, lasting and impactful. The day that you find you are doubting yourself, take private time to consider why that is. Elinor Stutz Opportunity CEO of Smooth Sale, Author & Inspirational Speakercenter_img September 17, 2016 Next Article Add to Queue 2 min read This story originally appeared on Personal Branding Blog Transform Dark Days into Opportunity Enroll Now for $5last_img read more

first_imgLuokung Technology Corp. (LKCO) (“Luokung” or the “Company”), a leading global spatial-temporal big-data technology company and a leading interactive location-based services company in China, announced that it has signed a stock purchase agreement to acquire 67.36% of Beijing BotBrain AI Technology Ltd and BOTBRAIN AI LIMITED (collectively “BotBrain “).The Company will invest RMB 20 million to BotBrain and will issue 804,162 ordinary shares at USD $7 per share to the former institution investors of BotBrain to obtain 67.36% (the “Acquisition”). The 32.64% share equity of BotBrain will be remained by Mr. Xueyu Lu, the founder and CEO of BotBrain, along with BotBrain ‘s core team members. After the Acquisition, Mr. Lu will continue as CEO of BotBrain AI.BotBrain was established in January 2016, and it has been becoming an advanced provider for intelligent content solutions in China. It’s artificial intelligence algorithms and technology are applied in Chinese semantic analysis, intelligent voice interaction, knowledge graph learning, personalized contents recommendation and other related big data analysis.There are two independent business brands in BotBrain. “Max” content brain is an AI content management and operation platform, which provides AI solutions based on its content services. “BotBrain Zhiyu” is an AI knowledge learning assistant system.Marketing Technology News: Acquia Acquires Mautic to Deliver First-Ever Open Marketing CloudBotBrain has been serving many well-known enterprises based in China, including People’s Daily Overseas, ChinaNews, Kaishu Story, Baby Tree, Baofeng, Bank of China, State Grid, FAW, CreditEase, Facebank and Kingsoft Cloud etc., which involve various industries including media, mobile internet, banking, automobile, financial services, retails and energy.BotBrain has started the cooperation with the Company in technology supports prior the Acquisition, it provides intelligent geographic information algorithms service for us, and Its technology of semantic analysis, knowledge graph and personalized contents recommendation significantly supports the LBS service of Luokung. After the Acquisition, BotBrain will put more investment in the research of intelligent spatial temporal data algorithm and application. BotBrain will provide critical intelligent technologies and application experiences to support our LBS business, personalized full-vector map, and enable us to improve the services we provide to mobile Internet industry and users. Therefore, the Company’s LBS business platform is able to gain a greater competitive advantage.Marketing Technology News: Mareana Named a 2019 Gartner Cool Vendor in Artificial Intelligence Across the Supply ChainThe founder and CEO of BotBrain, Mr. Lu Xueyu processes more than 40 patents relating to the contents intelligence service algorithms. Mr. Lu has more than 13 years experiences in big data and AI industry, he has had an in-depth comprehension and long-term practice in big data, AI and personalized recommendation and Mr. Lu is one of the earliest practitioners in this field in China. Mr. Lu worked in Tencent, Alibaba Youku and Xiaomi and was responsible for the construction and management of big data and artificial intelligence teams, gained many successful implementation experiences for the establishment of big data and recommendation systems. In 2006 in Tencent, Mr. Lu took the lead in using artificial intelligence technology in virus discovery, effectively helped Tencent to protect nearly 1 billion QQ users’ account information security. In Youku, Mr. Lu served as technical director and set up the big data and personalized recommendation system for videos, the system was able to proceed more than 100 billion data daily, it was the system with the highest recommendation accuracy in the field of video websites at that time. During the time in Xiaomi, Mr. Lu was the technical director and was in charge of Xiaomi’s data workshop, he was also responsible for the Xiaomi ecological big data business.Marketing Technology News: RevJet Announces Results of Second Ad Experience Sentiment Report Revealing Change in Sentiment, Behavior of Online Consumers Luokung Technology Corp. Announces to Acquire Artificial Intelligence Company PRNewswireMay 14, 2019, 2:55 pmMay 14, 2019 AcquisitionAIBotBrain AI Technologycontent managementLuokung TechnologyMarketing Technology NewsNews Previous ArticleTechBytes with Adam Solomon, Chief Marketing Officer at LotameNext ArticleGoogle Selects Webpals Mobile to Join App Campaign Partner Programlast_img read more

first_imgUnstoppable Domains, a software company building domains on blockchains, today announced which 60 .zil domains it will auction on June 27. These domains represent the top 60 most watched Zilliqa domain names on the Unstoppable Domains website. The top domain, bitcoin.zil, has already attracted 505 potential buyers.“We are excited to see growing enthusiasm for blockchain domains,” said Matthew Gould, Unstoppable Domains CEO. “These domains provide two very critical benefits to users: they enable people to send crypto to a single human readable name, and they offer a platform to create uncensorable websites. The concepts of free speech and growing the crypto community are really resonating with our customer base.”Marketing Technology News: Triton Digital Integrates Centro’s Basis Platform with the a2x Programmatic Marketplace.Zil domains have seen high demand over the past 3 months, even though top domains have yet to be released. Users can, however, watchlist the domains they are most interested in bidding on during the coming public auction. Here are the top 60 most watchlisted domains:Which domains will be up for auction?1. bitcoin2. crypto3. porn4. blockchain5. money6. insurance7. gold8. cars9. hotels10. satoshi11. bra12. zil13. usa14. bank15. wallet16. beer17. ethereum18. carinsurance19. lasvegas20. pay21. trump22. weed23. travel24. toys25. pizza26. cannabis27. xxx28. litecoin29. privatejet30. music31. xrp32. fb33. z34. shop35. 36036. coffee37. coin38. cash39. vacationrentals40. porno41. hotel42. payme43. booking44. diamond45. insure46. game47. exchange48. 149. ripple50. donaldtrump51. abc52. cardano53. auction54. shoes55. ai56. car57. we58. domain59. elonmusk60. israelThe auction will be split into two phases. During phase I, the 60 most watchlisted domains will be available for a buy now price of $10,000 each. Domains can be purchased using bitcoin, ethereum, litecoin, and bitcoin cash.Marketing Technology News: Mindtree to Showcase Contextual, Real-Time Solutions for Personalized Traveler Experiences at HITEC MinneapolisDuring phase II, domains can only be purchased with Zilliqa.Bidding will start between $10 and $1,000 depending on the price of the domain in the pre-order phase. Each subsequent bid must be at least 5 percent greater than the previous bid. If a person is outbid, they will immediately get their funds returned. New bids will add additional time (~1 hour) to the auction to prevent auction sniping. Also, bidding will be capped at $10,000 per domain. Anyone in the world can participate and anyone in the world can watch the auctions as they happen.Marketing Technology News: CoreMedia Announces CoreMedia Content Cloud – Marketing Connector on Salesforce AppExchange, the World’s Leading Enterprise Cloud Marketplace Marketing TechnologyMatthew GouldNewsUnstoppable DomainsZilliqa Domain Previous ArticleMarTech Interview with Duncan Stockdill, Co-Founder and CEO at CapsuleNext ArticleFranklin Sports Selects CommerceIQ To Empower Their E-Commerce Team To Manage Amazon Holistically Unstoppable Domains Announces the Top 60 Zilliqa Domain Names Up for Auction Business WireJune 19, 2019, 1:45 pmJune 19, 2019 last_img read more

first_img Source:https://canal.ugr.es/noticia/obesity-and-food-restrictions-proven-to-be-associated-with-less-food-enjoyment/ Reviewed by Alina Shrourou, B.Sc. (Editor)Nov 13 2018Researchers from the University of Granada (UGR) belonging to the Mind, Brain and Behavior Research Center (CIMCYC, from its name in Spanish) and the Faculty of Business and Economics have proven that adolescents who suffer from obesity feel less food enjoyment than those who have a normal weight. In addition, their work reveals that even trivial restrictions on food intake (that is, temporary diets) are associated with a reduction in pleasure.For this work, published in the journal Food Quality and Preference, a large sample of 552 adolescents between 11 and 17 years old from several high schools in Granada has had their emotional reactions analyzed during the visualization of images of sweet foods.Related StoriesResearchers propose new avenue in the search for anti-obesity drugsSupervised fun, exercise both improve psychosocial health of children with obesityNew technique reduces postoperative deficit of oxygen in the blood in patients with morbid obesityThus, the researchers observed that those adolescents who reported different types of dietary restrictions (different types of diet, dieting very often, skipping breakfast, eating less frequently, etc.), along with those who were obese and those who had unhealthy behaviors unrelated to food (such as smoking or having insufficient sleep), felt less pleasure, attraction and desire to eat the highly palatable foods they were looking at (images of sweets, donuts, ice‑creams, chocolate crêpes, etc.).As explained by Laura Miccoli, main author of this study, “adolescence, typically associated with greater body dissatisfaction, is a key stage for the development of risky eating behaviors, related both to uncontrolled restrictions on food intake -which may lead to to the development of eating disorders- and with the stabilization of overweight and obesity.” Hence the importance of studies that approach both food‑related disorders from an integrative perspective.A pioneering studyNot in vain, the research led by the UGR is the first study that has examined the adolescents’ emotions toward sweet food cues based on a constellation of risk behaviors, related to both obesity and eating disorders.In the light of the results obtained, the UGR scientists point out that those adolescents who feel more pleasure or enjoyment when eating “have a healthy relationship with food, and this pleasure may be a possible protective factor against eating and weight‑related disorders.”Therefore, “consistent with recent prevention strategies, it is important to change the perspective on the enjoyment of food with respect to the prevention of obesity, banishing the idea that we should avoid the pleasure of eating. On the contrary: we should take advantage of it, and make food enjoyment -the ‘slow food movement’- a tool for healthy eating,” Miccoli points out.last_img read more

first_img70% of HGSC relapse despite treatment, becoming resistant to chemotherapy, which makes the new discovery a true potential breakthrough in the treatment of this tumor.All life at cellular and organism level depends upon thousands of life processes that provide and degrade a range of chemicals required for proper function of the cells and tissues. These intricately interdependent processes together they make up the body’s metabolism. By Dr. Liji Thomas, MDJul 14 2019A new study shows that targeting a specific protein found within quickly spreading high-grade serous carcinomas (HGSC) of the ovary could help contain these cancers. HGSC is the most common and deadly form of epithelial ovarian cancer, which is itself the deadliest cancer of the female reproductive tract. When HGSC spreads outside the ovaries, within the peritoneal cavity, it forms detached balls called spheroids, which may look and act differently from the adherent cells of the primary tumor.The study is published in the current issue of the journal Molecular Cancer Research. However, as researcher Erika Dahl explains, “A hallmark of cancer cells is that their metabolic processes are often different from normal, healthy cells.”  This is called metabolic reprogramming. As one of the outcomes, study author Katherine Aird says, “Cancer cells can grow forever without stimulus.” Cancer cell Illustration. Image Credit: Jovan Vitanovski / Shutterstock The good news about the newly discovered protein is that it can be inhibited, thus inactivating cell processes within ovarian cancer cells to switch them from a constitutively proliferative cell cycle to one which results in senescence, or going to sleep. The key role of the protein was identified on cell culture experiments by researchers at Penn State College of Medicine.The current study focused on teasing out the differences in the metabolism of ovarian cancer cells by comparing them with cells from a normal fallopian tube.The route used to achieve this was quantitative spectrometry, which helped analyze the metabolites produced by various cellular pathways in the two type of tissue. Among the differences, it was revealed that cancer cells utilized glucose, a form of sugar, via the key energy cycle called the citric acid cycle, far more often, as against the more common use of an oxygen-requiring pathway called aerobic glycolysis. This accounts for the presence of a high level of citric acid activity in all high-grade serous ovarian cancer cells.  Related StoriesStudy reveals link between inflammatory diet and colorectal cancer riskVirus killing protein could be the real antiviral hero finds studyNew study to ease plight of patients with advanced cancerThis means that many therapies which inhibit the breakdown of glucose (glycolysis) to destroy cancer cells may be quite ineffective. Dahl commented that this could often result, in fact, in the production of toxins that harm normal healthy tissue.Instead, the team in the current study looked at the effects of inhibiting the wildtype or normal form of an enzyme, isocitrate dehydrogenase 1 (IDH 1), which plays a vital part in the citric acid cycle. They selected this protein because it was the only one in this pathway that is expressed at higher levels in both adherent and spheroid tumor cells. Increased activity of this enzyme severely impacts progression-free survival, which is an important outcome measured in assessing the effectiveness of any cancer therapy.Mutants of this protein are common in other tumors, but the wildtype form is typically present in cells within HGSC. The researchers hypothesize that the presence of this enzyme is an important advantage to these cells, and its inhibition is a key step to inducing senescence.The researchers found that suppressing the work of this protein stopped cell division completely by suppressing the activity of multiple other genes, inhibiting vital metabolic pathways. Both adherent cells of the primary tumor, and spheroid cells of secondary HGSC, become senescent when the wildtype IDH 1 enzyme is inhibited. Thus, this could be an excellent way to treat HGSC at all stages. This is an important consideration, as ovarian cancers are rarely diagnosed at early stages.While there are already FDA (US Food and Drug Administration)-approved drugs against one of the mutant forms of this enzyme, the team wondered whether they would work against the wildtype form as well. They found that one did, and this is now a part of their continued research agenda.Aird says, “One of our long-term goals is to try and repurpose this already-approved drug as a treatment for this form of ovarian cancer.” Besides adapting existing drugs against the enzyme to fight this type of cancer, the researchers want to examine the differences in the metabolic functioning of normal and HGSC cells more closely. Another goal is to examine the effectiveness of combining IDH 1 inhibitors with other treatments. Journal reference:Targeting IDH1 as a Prosenescent Therapy in High-grade Serous Ovarian Cancer, Erika S. Dahl, Raquel Buj, Kelly E. Leon, Jordan M. Newell, Yuka Imamura, Benjamin G. Bitler, Nathaniel W. Snyder and Katherine M. Aird, Mol Cancer Res June 17 2019 DOI: 10.1158/1541-7786.MCR-18-1233, http://mcr.aacrjournals.org/content/early/2019/06/17/1541-7786.MCR-18-1233last_img read more

first_img Explore further Britain called for a first-of-its-kind watchdog for social media that could fine executives and even ban companies. And a European Union parliamentary committee approved a bill giving internet companies an hour to remove terror-related material or face fines that could reach into the billions.”We are forcing these firms to clean up their act once and for all,” said British Home Secretary Sajid Javid, whose department collaborated on Britain’s proposal.Opponents warned the British and EU measures could stifle innovation and strengthen the dominance of technology giants because smaller companies won’t have the money to comply. That, in turn, could turn Google and Facebook into the web’s censors, they said.The push to make the big companies responsible for the torrent of material they carry has largely been driven by Europeans. But it picked up momentum after the March 15 mosque shootings in New Zealand that killed 50 people and were livestreamed for 17 minutes. Facebook said it removed 1.5 million videos of the attacks in the 24 hours afterward.The U.S., where government action is constrained by the First Amendment right to free speech and freedom of the press, has taken a more hands-off approach, though on Tuesday, a House committee will press Google and Facebook executives on whether they are doing enough to curb the spread of hate crimes and white nationalism.Australia last week made it a crime for social media platforms not to quickly remove “abhorrent violent material.” The offense would be punishable by three years in prison and a fine of 10.5 million Australian dollars ($7.5 million), or 10% of the platform’s annual revenue, whichever is larger. New Zealand’s Privacy Commissioner wants his country to so the same.The British plan would require social media companies such as Facebook and Twitter to protect people who use their sites from “harmful content.” The plan, which includes the creation of an independent regulator funded by a tax on internet companies, will be subject to public comment for three months before the government publishes draft legislation. Citation: Facebook, Google face widening crackdown over online content (2019, April 9) retrieved 17 July 2019 from https://phys.org/news/2019-04-facebook-google-widening-crackdown-online.html Tech giants like Facebook and Google came under increasing pressure in Europe on Monday when countries proposed stricter rules to force them to block extreme material such as terrorist propaganda and child porn. In this April 18, 2017 file photo, conference workers speak in front of a demo booth at Facebook’s annual F8 developer conference, in San Jose, Calif. The U.K. for the first time on Monday April 8, 2019, proposed direct regulation of social media companies, with senior executives potentially facing fines if they fail to block damaging content such as terrorist propaganda or images of child abuse. (AP Photo/Noah Berger, File) “No one in the world has done this before, and it’s important that we get it right,” Culture Secretary Jeremy Wright told the BBC.Facebook’s head of public policy in Britain, Rebecca Stimson, said the goal of the new rules should be to protect society while also supporting innovation and freedom of speech.”These are complex issues to get right, and we look forward to working with the government and Parliament to ensure new regulations are effective,” she said.Britain will consider imposing financial penalties similar to those under the EU’s online data privacy law, which permits fines of up to 4% of a company’s annual worldwide revenue, Wright said. In extreme cases, the government may also seek to fine individual company directors and prevent companies from operating in Britain.Under the EU legislation that cleared an initial hurdle in Brussels, any internet companies that fail to remove terrorist content within an hour of being notified by authorities would face similar 4% penalties. EU authorities came up with the idea last year after attacks highlighted the growing trend of online radicalization.The bill would apply to companies providing services to EU citizens, whether or not those businesses are based in the EU’s 28 member countries. It still needs further approval, including from the full European Parliament.It faces heavy opposition from digital rights organizations, tech industry groups and some lawmakers, who said the 60-minute deadline is impractical and would lead companies to go too far and remove even lawful material.”Instead, we call for a more pragmatic approach with removals happening ‘as soon as possible,’ to protect citizens’ rights and competitiveness,” said EDIMA, a European trade group for new media and internet companies.Opponents said the measure also places a bigger burden on smaller internet companies than on giants like Facebook and Google, which already have automated content filters. To help smaller web companies, the bill was modified to give them an extra 12 hours for their first offense, a measure opponents said didn’t go far enough.Mark Skilton, a professor at England’s Warwick Business School, urged regulators to pursue new methods such as artificial intelligence that could do a better job of tackling the problem.”Issuing large fines and hitting companies with bigger legal threats is taking a 20th-century bullwhip approach to a problem that requires a nuanced solution,” he said. “It needs machine learning tools to manage the 21st-century problems of the internet.”Wright said Britain’s proposed social-media regulator would be expected to take freedom of speech into account while trying to prevent harm.”What we’re talking about here is user-generated content, what people put online, and companies that facilitate access to that kind of material,” he said. “So this is not about journalism. This is about an unregulated space that we need to control better to keep people safer.” UK takes aim at social networks that fail to quash ‘hateful’ content This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. © 2019 The Associated Press. All rights reserved.last_img read more