June 8, 2015The workshop that started on May 24. 2015 is in its third week and here are some of the work activities.Lindsey and Jennifer are working in the weldingshop, here cutting and sanding angle iron under the tutalage of construction crew and main welder Paolo Van Erp.[photos by Sue Kirsch]Eliot is working with Isaac in the Redroom, preparing one of the walls for installation of pegboard.Zoe is working with Dr. Sparks, installing lighting fixtures in Unit 9-1, learning about electicity.Cecilia and Conor are building and spackeling a form for a set of planters for the East Housing steps.Sophie and Go are working with David dismantling some of the Easthousing kitchen.More to come
Kenya-based Econet Media has launched a free-to-air sports channels that will offer coverage of English Premier League football as well as NBA basketball, Extreme Fighting Championship combat sports and NFL American football.The channel, Kwesé Free Sports, will be available on digital-terrestrial TV and on satellite in Kenya via free-to-air set-top boxes.The channel has exclusive free-to-air rights to air one Premier League match of the week every Saturday.Kenyan content on the channel includes Xtreme Outdoor Africa, Ball N’Africa and Sports Stars Uncovered.Econet Media is a unit of Econet Wireless, a mobile telecommunications operator founded by Zimbabwean businessman Strive Masiyiwa. Masiwiya revealed at the end of last year that he was planning to launch a broader pay TV service called Kwesé TV, offering a mix of sports and entertainment programming across sub-Saharan Africa, including to mobile users.He said that the company’s satellite unit, Liquid Sat, had built a platform to deliver the service via DTH.“We are thrilled to have reached this important milestone. Our goal is to bring African viewers the very best viewing experience and we are able to provide this for free in a way that is accessible for our viewers,” said Ben Amadasun, CEO Kwesé Free Sports.“Not only will we air local content, but we will also commission the production of original work by local production companies, as part of our commitment to developing the local industry”, said Monicah Ndungu general manager of the channel.
Ukrainian broadcaster 1+1 Media Group is to use capacity on SES’s satellite at 5 degrees East to broadcast eight channels.Under a long-term agreement between the pair, 1+1 will lease of one transponder on the Astra 4A satellite positioned at 5 degrees East.The capacity contracted by 1+1 Media will enable the group to host all of its eight channels on SES’s satellite. Seven of its DTH channels serve the Ukrainian market: 1+1, 2+2, TET, PlusPlus, Bigudi, Unian TV and Kvartal TV.The other channel of the group, 1+1 International, is targeted at the Ukrainian diaspora in Europe, and is an international version of the 1+1 channel.1+1 Media Group recentlystruck a deal to add the latter channel to a new OTT service aimed at expatriate and ethno-linguistic groups launched by Cisco in partnership with Sky.“1+1 Media Group is one of Ukraine’s major players in the market. We have already been hosting some of the group’s TV channels. This new agreement brings our long-standing relationship to a new level, and we are very much looking forward to delivering all of 1+1 Media Group’s channels to both Ukrainian and international audiences,” said Ferdinand Kayser, chief commercial officer of SES.“We have been relying on SES’s services over the past several years, and we are very pleased that our collaboration is expanding. SES has extensive experience in the Ukrainian market, and a proven track record in delivering top quality services. We are confident in SES as a partner in bringing our channels to our audiences in Ukraine and abroad,” said Yaroslav Pakholchuk, chief operational officer of 1+1 Media Group.
Staff Writer. Covers leadership, media, technology and culture. The only list that measures privately-held company performance across multiple dimensions—not just revenue. This article is included in Entrepreneur Voices on Company Culture, a new book containing insights from more than 20 contributors, entrepreneurs, and thought leaders.During a Tuesday meeting to discuss an overhaul of Uber’s company culture, former board member David Bonderman proved exactly why the conversations needed to happen in the first place.At the start of the all-hands meeting, Arianna Huffington, who was the first woman to join the company’s board last year, announced the addition of Nestlé executive Wan Ling Martello to the board, increasing the representation of women on the board from 14 to 25 percent.“There’s a lot of data that shows when there’s one woman on the board, it’s much more likely that there will be a second woman on the board,” Huffington noted.That’s when Bonderman interrupted.“Actually what it shows is it’s much likely to be more talking.”In the recording obtained by Yahoo Finance, you can hear Huffington respond at first with awkward laughter. And then her reply: “Oh. Come on, David. Don’t worry, David will have a lot more talking to do as well.”That is not to be the case, as Bonderman resigned shortly after the meeting, which, it bears repeating, was convened to talk about recommendations to change Uber’s culture after allegations of systemic discrimination and sexual harassment.Related: 3 Lessons Every CEO Can Learn From Travis Kalanick’s Emotional Meeting With Uber’s Female EngineersBonderman, the 74-year-old founding partner of investment firm TPG Capital, apologized for the “disrespectful” comment via an internal memo to Uber employees and issued this statement about his departure:”I do not want my comments to create distraction as Uber works to build a culture of which we can be proud. I need to hold myself to the same standards that we’re asking Uber to adopt. Therefore, I have decided to resign from Uber’s board of directors, effective tomorrow morning.”Earlier on Tuesday, CEO Travis Kalanick also announced that he would be taking a leave of absence in order to, as he shared in an email to the company, “take some time off of the day-to-day to grieve my mother, whom I buried on Friday, to reflect, to work on myself, and to focus on building out a world-class leadership team. The ultimate responsibility, for where we’ve gotten and how we’ve gotten here rests on my shoulders,” Kalanick wrote. “There is of course much to be proud of but there is much to improve. For Uber 2.0 to succeed there is nothing more important than dedicating my time to building out the leadership team. But if we are going to work on Uber 2.0, I also need to work on Travis 2.0 to become the leader that this company needs and that you deserve.”Related: Travis Kalanick to Take a Leave of Absence. Here Are 9 CEOs Who Were Fired or Decided to Step Down.So what exactly is Uber 2.0 going to look like?Over the past few months, former attorney general Eric Holder and Tammy Albarrán, partners at law firm Covington & Burling, were tasked with investigating the allegations made by former engineer Susan Fowler and others.They interviewed more than 200 Uber employees and provided a set of recommendations pertaining to how the company should address discrimination, harassment and retaliation and how it could “ensure that its commitment to a diverse and inclusive workplace was reflected not only in the company’s policies but made real in the experiences of each of Uber’s employees.”The recommendations include:Providing more support for the human resources department and establishing clear protocols to track complaints.Mandatory training for senior executives, HR staffers, managers and people in the position to interview prospective employees, particularly around the topics of promoting inclusion and combatting unconscious bias.In terms of recruiting and developing talent, implementing a blind resume review, and increased transparency when it comes to performance reviews and promotions.The prohibition of romantic or intimate relationships between supervisor/subordinates and the consumption of alcohol during work hours, at after work events and at company-sponsored events.An update of discrimination and harassment policies including instituting a zero-tolerance policy for violators of those rules — no matter what position they hold in the company — and explicit protection against harassment from not only other employees, but third-parties the company deals with such as clients to vendors.Related: A 2013 Letter From Uber’s Travis Kalanick Lays Out Sex Rules for Employees at Company PartyA lot of these seem quite standard. But when you look at former engineer Susan Fowler’s blog post and Kalanick’s 2013 Miami letter side by side, the necessity for Holder and Albarrán to explicitly state things such as the importance of “de-emphasizing alcohol as a component of work events,” or that policies should be applied consistently across the company with no special treatment afforded to any one employee is pretty glaring.One passage in particular about Uber’s 14 cultural values speaks volumes about where Uber ran aground. Holder and Albarrán recommended that the company communicate with its employees to reassess and develop a core list of values that are accessible and easy to understand. “Eliminate those values which have been identified as redundant or as having been used to justify poor behavior, including Let Builders Build, Always Be Hustlin’, Meritocracy and Toe-Stepping, and Principled Confrontation; and encourage senior leaders to exhibit the values on a daily basis and to model a more collaborative and inclusive Uber culture,” the recommendation reads. “Leaders who embody these values should be part of the process of redefining Uber’s values and should be role models for other leaders within the company.”Related: Uber CEO Travis Kalanick Says He Needs to ‘Grow Up’ After Video of Argument With a Driver ReleasedUber has long had a reputation for aggressive tactics in its dealings with regulators and competitors. It was seen, for better or worse, as one of the key drivers of its rapid growth. But clearly, as Uber’s experience shows us, growth and success are not one in the same.In an interview with Vanity Fair in 2014, Kara Swisher asked Kalanick about the nature of the interactions with the leaders of the cities (some of whom he described as “really awesome, but most are uninspired”) his business was disrupting.“If you don’t agree with the core principles, which are the premise of that compromise, then you have to have what I call principled confrontation. And so that is the thing that we do that I think can rub some people the wrong way.”If you’re beginning with the premise that compromise doesn’t work for you, and every interaction is a war of attrition, you can let people build all they want, but what exactly are you working toward?If you’re always hustlin’ — though if they do keep that one, I would urge them to restore the “g” to its rightful place — you don’t stop to think about where the pitfalls may be or whether you might be in the wrong. Uber’s experience shows us that is kind of approach is a recipe for collapsing under the weight of your own hubris.Related: If Elon Musk Can Admit His Mistakes, Then So Can YouIn Uber’s San Francisco headquarters, up until this week, the office’s main conference room was called aptly, the War Room. Bloomberg reported that along with the multitude of changes recommended by Covington & Burling, the room is now going to be called the Peace Room. It’s a bit on nose, but you can appreciate the thought, as long as it’s not just lip service.Uber’s culture is not going to change overnight, but now the company seems to have the self-awareness and tools in place to build an environment where values aren’t used, as per Holder and Albarrán’s description, to “justify poor behavior.”So what can we learn from Uber’s newfound emphasis on internal, rather than external growth? Company culture isn’t about perks or empty aphorisms that look good on a T-shirt. Simply, people want to be heard, they want their work to be valued and they want to be treated with respect. When you build your company culture, start there. Entrepreneur Staff 82shares Nina Zipkin Image credit: Spencer Platt | Getty Images 2019 Entrepreneur 360 List Apply Now » Uber June 15, 2017 Uber Needs to Recreate its Company Culture. Here’s What You Can Learn From Its Mistakes. Add to Queue Start by treating people with respect. It’s as simple as that. 8 min read Next Article
Next Article February 12, 2009 Technology The only list that measures privately-held company performance across multiple dimensions—not just revenue. Ustream.TVFounders/ages: Gyula Feher, 30; John Ham, 30; Brad Hunstable, 30Launched: 2007App: A destination platform for streaming live video over the internet; includes co-hosting, chat and hyperlink overlay functionsWhy it works: While YouTube hosts previously recorded videos, Ustream hosts live content, allowing real-time viewing and interaction.Just UptimeFounder/age: Chris Phillips, 25Launched: June 2008App: A website- and server-monitoring application that provides instant e-mail notifications, SMS text alerts and detailed reporting when your website or server is downWhy it works: Sure, a few people out there spend every waking moment online. But for those who don’t, this intuitive app gives them a heads up when issues arise.OoVooCEO/age: Philippe Schwartz, 44Launched: 2007App: An innovative video service for creating video messages, real-time video chats for up to six people and live video callsWhy it works: Communication, whether between friends and family or employees and business partners, has moved online. OoVoo allows face-to-face conversations when being in the same room isn’t possible. Lindsay Holloway Apply Now » This story appears in the March 2009 issue of Entrepreneur. Subscribe » If you’re thinking about creating a web app–whether as a business or to use in your existing business–its construction costs and time can run the gamut. It depends on many factors: how complicated the technology is, what tools you use to build it and so on. But details aside, here are a few web app entrepreneurs who show us it can be done.Iotum CalliflowerFounders/ages: Alec Saunders, 45; Howard Thaw, 52Launched: June 2008App: A meeting tool that bridges businesses and social networks to allow the planning of and participation in interactive conference callsWhy it works: The solution is all-encompassing: It combines high-quality audio conferencing, scheduling, file sharing and collaboration in an easy-to-use interface.MedAppsFounder/age: Kent E. Dicks, 48Launched: 2005App: A two-part application that provides a remote health-monitoring solution; the mobile app collects patient data and readings that a health-care professional monitors via the web appWhy it works: MedApps makes remote health monitoring accessible and inexpensive to the more than 133 million people in the U.S. with at least one chronic condition. Magazine Contributor Yes, You Can Build Your Own Web App 2019 Entrepreneur 360 List Get started nowInspired to build your own web app? These sites can help you take that first step. –shares 2 min read Add to Queue Caspio Coghead Intuit QuickBase Zoho Creator
Your reaction to particularly awful days can make or break future success. The better action to take is to remain as calm as possible. Take quiet time to analyze how far you have come. Think about the twists and turns, and what currently has you stopped in your tracks.Numerous conversations revealed that many almost quit their current endeavors. But one common factor as to why they did not quit helped them to prevail: They enjoy what they do too much! Ironically, it has become their way of life.As uncertainty hits, follow these two suggestions:Take the time needed to uncover the better route.Convert a negative frame of mind into a positive.Reframe the situationOne sales technique referred to as “Reframing” applies very well to difficult situations. Whether personal or trying to work with a client, the first step is to figure out where the discontent originates. Upon recognizing the misstep, it becomes easier to work together to find the better solution. By asking a series of questions such as, “What if…” the improved path begins to reveal itself.On the personal side, moving from negative to positive thought is the beginning step for improvement. The change in attitude makes an enormous difference in providing increased opportunity to save the day.The day that you find you are doubting yourself, take private time to consider “the why” that is. Most likely, one of your peers will have had a similar experience. Have a conversation about how they dealt with it and ask for recommendations on how to handle. Their insights won’t necessarily apply or even matter. It’s more about the conversation itself. Just by unleashing the dilemma is all it takes to get back to full steam ahead. As others see you meeting negativity and obstacles head on, they come to admire your steadfast personal brand.Tips:When negativity hits, stop to examine the origin.Decide whether changes need to be made.Should changes be in order, decide whether they are minor or major.Begin the process by eliminating the no longer needed.Create a list of what needs to be fixed.Prioritize the list in order of immediate need.Re-energize yourself and/or business by communicating. –shares Image credit: Shutterstock Fireside Chat | July 25: Three Surprising Ways to Build Your Brand Learn from renowned serial entrepreneur David Meltzer how to find your frequency in order to stand out from your competitors and build a brand that is authentic, lasting and impactful. The day that you find you are doubting yourself, take private time to consider why that is. Elinor Stutz Opportunity CEO of Smooth Sale, Author & Inspirational Speaker September 17, 2016 Next Article Add to Queue 2 min read This story originally appeared on Personal Branding Blog Transform Dark Days into Opportunity Enroll Now for $5
Source:https://news.illinois.edu/view/6367/775169 Reviewed by James Ives, M.Psych. (Editor)Apr 17 2019Oxidants found within living organisms are byproducts of metabolism and are essential to wound-healing and immunity. However, when their concentrations become too high, inflammation and tissue damage can occur. University of Illinois engineers have developed and tested a new drug-delivery system that senses high oxidant levels and responds by administering just the right amount of antioxidant to restore this delicate balance.The findings are published in the journal Small.Many pharmaceuticals include specialized polymers and particles that control the timing or concentration of the drug released once administered, the researchers said. However, these additives can hamper crystallization during the manufacturing phase of some drugs – like antioxidants – causing them to dissolve in the body in an uncontrolled manner.”We saw an opportunity here to develop a different kind of drug-delivery system that could sense the level of oxidant in a system and respond by administering antioxidant as needed,” said chemical and biomolecular engineering professor and study co-author Hyunjoon Kong.Kong and his team found a way to assemble crystals of catechin – the bright green antioxidant found in green tea – using a polymer that can sense when oxidant concentrations become too high. The researchers tested the responsiveness of the resulting catechin crystal-containing polymer in the common freshwater planktonic crustacean Daphnia magna, the water flea.”Heart rate is an indication of the extent to which potentially toxic chemicals influence physiology in water fleas,” Kong said. “Daphnids are often used to monitor environmental impacts on ecological systems, and because their hearts are similar to those of vertebrates, they are also used to evaluate the efficacy of cardioprotective drugs.”Related StoriesChronic inflammation removes motivation by reducing dopamine in the brainCancer incidence among children and young adults with congenital heart diseaseStudy measures antioxidant levels in edible insectsThe researchers exposed the daphnids to water contaminated with sublethal concentrations of the natural oxidant hydrogen peroxide while monitoring their heart rate. They found that the daphnids’ mean heart rates dropped from 348 to 290 and 277 beats per minute, depending on the concentration of hydrogen peroxide used.When the team added the new catechin crystal assembled with polymer to the experiment, the water fleas eventually recovered a close-to-normal heart rate.Beyond the potential pharmaceutical uses for the new polymer, Kong’s group is looking into its use for curtailing the impact of highly oxidizing chemicals in natural waterways.”Hydrogen peroxide is often used to clean water fouled by excessive algae, and this raises concern about how the oxidant may be affecting living organisms in water,” he said. “We think this new antioxidant-delivery system could be used to address the problem of over-oxidized natural waters.”The researchers plan to push ahead with developing the polymer for pharmaceutical and environmental uses. “This study proved a concept, but we have more work to do,” Kong said. “There is concern over the safety of the specific polymer we used – polyethylenimine diselenide – but we are getting close to finding a viable replacement.”
70% of HGSC relapse despite treatment, becoming resistant to chemotherapy, which makes the new discovery a true potential breakthrough in the treatment of this tumor.All life at cellular and organism level depends upon thousands of life processes that provide and degrade a range of chemicals required for proper function of the cells and tissues. These intricately interdependent processes together they make up the body’s metabolism. By Dr. Liji Thomas, MDJul 14 2019A new study shows that targeting a specific protein found within quickly spreading high-grade serous carcinomas (HGSC) of the ovary could help contain these cancers. HGSC is the most common and deadly form of epithelial ovarian cancer, which is itself the deadliest cancer of the female reproductive tract. When HGSC spreads outside the ovaries, within the peritoneal cavity, it forms detached balls called spheroids, which may look and act differently from the adherent cells of the primary tumor.The study is published in the current issue of the journal Molecular Cancer Research. However, as researcher Erika Dahl explains, “A hallmark of cancer cells is that their metabolic processes are often different from normal, healthy cells.” This is called metabolic reprogramming. As one of the outcomes, study author Katherine Aird says, “Cancer cells can grow forever without stimulus.” Cancer cell Illustration. Image Credit: Jovan Vitanovski / Shutterstock The good news about the newly discovered protein is that it can be inhibited, thus inactivating cell processes within ovarian cancer cells to switch them from a constitutively proliferative cell cycle to one which results in senescence, or going to sleep. The key role of the protein was identified on cell culture experiments by researchers at Penn State College of Medicine.The current study focused on teasing out the differences in the metabolism of ovarian cancer cells by comparing them with cells from a normal fallopian tube.The route used to achieve this was quantitative spectrometry, which helped analyze the metabolites produced by various cellular pathways in the two type of tissue. Among the differences, it was revealed that cancer cells utilized glucose, a form of sugar, via the key energy cycle called the citric acid cycle, far more often, as against the more common use of an oxygen-requiring pathway called aerobic glycolysis. This accounts for the presence of a high level of citric acid activity in all high-grade serous ovarian cancer cells. Related StoriesStudy reveals link between inflammatory diet and colorectal cancer riskVirus killing protein could be the real antiviral hero finds studyNew study to ease plight of patients with advanced cancerThis means that many therapies which inhibit the breakdown of glucose (glycolysis) to destroy cancer cells may be quite ineffective. Dahl commented that this could often result, in fact, in the production of toxins that harm normal healthy tissue.Instead, the team in the current study looked at the effects of inhibiting the wildtype or normal form of an enzyme, isocitrate dehydrogenase 1 (IDH 1), which plays a vital part in the citric acid cycle. They selected this protein because it was the only one in this pathway that is expressed at higher levels in both adherent and spheroid tumor cells. Increased activity of this enzyme severely impacts progression-free survival, which is an important outcome measured in assessing the effectiveness of any cancer therapy.Mutants of this protein are common in other tumors, but the wildtype form is typically present in cells within HGSC. The researchers hypothesize that the presence of this enzyme is an important advantage to these cells, and its inhibition is a key step to inducing senescence.The researchers found that suppressing the work of this protein stopped cell division completely by suppressing the activity of multiple other genes, inhibiting vital metabolic pathways. Both adherent cells of the primary tumor, and spheroid cells of secondary HGSC, become senescent when the wildtype IDH 1 enzyme is inhibited. Thus, this could be an excellent way to treat HGSC at all stages. This is an important consideration, as ovarian cancers are rarely diagnosed at early stages.While there are already FDA (US Food and Drug Administration)-approved drugs against one of the mutant forms of this enzyme, the team wondered whether they would work against the wildtype form as well. They found that one did, and this is now a part of their continued research agenda.Aird says, “One of our long-term goals is to try and repurpose this already-approved drug as a treatment for this form of ovarian cancer.” Besides adapting existing drugs against the enzyme to fight this type of cancer, the researchers want to examine the differences in the metabolic functioning of normal and HGSC cells more closely. Another goal is to examine the effectiveness of combining IDH 1 inhibitors with other treatments. Journal reference:Targeting IDH1 as a Prosenescent Therapy in High-grade Serous Ovarian Cancer, Erika S. Dahl, Raquel Buj, Kelly E. Leon, Jordan M. Newell, Yuka Imamura, Benjamin G. Bitler, Nathaniel W. Snyder and Katherine M. Aird, Mol Cancer Res June 17 2019 DOI: 10.1158/1541-7786.MCR-18-1233, http://mcr.aacrjournals.org/content/early/2019/06/17/1541-7786.MCR-18-1233