first_imgBelgacom increased its TV subscriber base by 236,000 last year, ending December with a total of 1.2 million.The Belgian telco lost some of the rights it held to broadcast Jupiler League football matches but CEO Didier Bellens said this was not longer affecting churn rates. “In 2011 we had to make some strategic choices, for which we maintained our discipline and opted not to take the easy road but to hold on to our end goal, value creation. As such we were vigilant not to overpay for Belgian football broadcasting rights. This now proves to have been the right choice since football-related churn is back to previous levels, when we had all the rights”Revenue from TV services increased 14.3% year-on-year to €208 million.Belgacom said its bundling strategy was paying off. Last year it added 219,000 multi-play subscribers, ending December with a total of 1.09 million ‘Packs’ customers.The telco reported total revenues of €6.4 billion for 2011, down 3% year-on-year.last_img read more

first_imgOn Friday ands Saturday night the place will be rocking with the super-pub disco back with DJ Marty Curran spinning the decks.It promises to be yet another SUPER weekend at Sister Sara’s.Check out all the snaps from last weekend below. SUPERB DRINK PROMOTIONS ON OFFER TO CELEBRATE ‘END OF TERM’ PARTY AT SISTER SARA’S was last modified: May 20th, 2015 by stephenstephen Tags: EntertainmentFeaturesNewsSister Sara’s ShareTweet WEEKEND PREVIEW: Management at Sister Sara’s are providing a real treat to help student’s wind-down after a stressful exam period with a superb drinks promotion.It’s been tough for all you academics at the LYIT and we all know that exams are a stressful and tiring time. However, we all know that when the exams finish you need a MASSIVE party to blow off some steam. At Letterkenny super-pub Sister Sara’s we’re hosting a HUGE end of term party to kick-start your summer.We’re also offering some superb offers on drink to get you in the partying spirit.You can get THREE beers for just €10, FOUR JAGER BOMBS for just €10 and you can buy one get one FREE on our Strawberry Daiquiri’s.last_img read more

first_imgMary Blake Tourism Officer with Council who is leading the local campaign said: “We are delighted that our bid is through to the shortlisted stage. Derry is galvanised under the ‘LegenDerry Food’ mantra, promoting exceptional quality and locally sourced food.“The ancient Walled City has many high quality and independently accredited restaurants along with quality cafes and delis.“Eminent food critics such as Georgina Campbell have claimed that we are now justifiably flagged as the North West’s Gourmet Capital.“Winning Foodie Town Ireland would be a real testament to the food revolution that has been taking place in our city over recent years.“Voting for Derry will support all our hardworking chefs, artisan food producers, fishermen, farmers, restaurateurs and hospitality staff.”Derry has been named among the top ten food destinations in Ireland and two independent assessors will now visit the city in the coming weeks to see what’s on the local menu. A national public vote will carry equal weight in the deciding the overall winner.You can register your support for the local food industry by going to www.foodietowns.ie and voting before 5pm on October 2nd.DERRY HAS A BITE AT FOODIE TOWN TITLE was last modified: September 17th, 2015 by John2John2 Tags: DERRY HAS A BITE AT FOODIE TOWN TITLEFOODIE TOWN OF IRELANDMARY BLAKETOURISM OFFICER ShareTweet “The city is undoubtedly establishing itself as a premier food destination and with the success of our recent food festivals, including the Flavours of the Foyle and the Legenderry Food Festival, our reputation continues to grow.“I am a huge supporter of local restaurants and food producers and Council is committed to supporting and growing the food industry here in the North West.“Winning the Foodie Town of Ireland title will gain further national recognition and enhance the city’s profile as a top destination for food tourism.”The Foodie Town of Ireland competition recognises the efforts made to establish a location’s foothold in the food tourism market, through events and activities such as food festivals, gourmet trails and markets, as well as establishing a reputation for dining excellence. THE Mayor of Derry City and Strabane District, Councillor Elisha McCallion, is calling on people across the district to back an online campaign to have Derry crowned the Foodie Town of Ireland.The city has been shortlisted in the prestigious national industry competition which is organised by the Restaurants of Ireland and a public vote could sway the outcome.With two weeks left to vote, Mayor McCallion urged local food fans to register their support online. “I am thrilled to see Derry shortlisted and I’ve already voted online.last_img read more

first_img – NEW WARNING FROM DOUG CASEY – READ IMMEDIATELY Over the years, Doug Casey’s forecasts have caused a lot of controversy… Like during the peak of the dot-com bubble when he warned a major crash in tech stocks was near… Or near 2008 when he warned America’s financial structure would be threatened with collapse. Critics called him “offensive,” “brash,” “irreverent.” But Doug was spot-on, every time. Not only that… Folks who heeded his warnings had the opportunity to make rare and extraordinary gains of 770%, 1,333%, and more. Yet, those could be a drop in the bucket if his latest controversial forecast about President Trump is right. Click here for the full story. Recommended Links — WARNING: Don’t File Social Security Benefits Until You See This We just uncovered something shocking that could mean the difference between collecting a meager $1,000 from Social Security… Or getting up to $6,235 a month you can use for your retirement. That’s real cash deposited in your account… coming from the private sector. But according to a law that governs this special situation, you must act before April 21. Click here to get started today. Editor’s note: The “Greater Depression” has started… Yesterday, Casey Research founder Doug Casey compared what happened in the 1930s to what’s going on today. Below, he breaks down more of these likely differences… By Doug Casey, founder, Casey Research PRICES 1930s Prices dropped radically because billions of dollars of inflationary currency were wiped out through the stock market crash, bond defaults, and bank failures. The government, however, somehow equated the high prices of the inflationary ’20s with prosperity and attempted to prevent a fall in prices by such things as slaughtering livestock, dumping milk in the gutter, and enacting price supports. Since the collapse wiped out money faster than it could be created, the government felt the destruction of real wealth was a more effective way to raise prices. In other words, if you can’t increase the supply of money, decrease the supply of goods. Nonetheless, the 1930s depression was a deflationary collapse, a time when currency became worth more and prices dropped. This is probably the most confusing thing to most Americans since they assume—as a result of that experience—that “depression” means “deflation.” It’s also perhaps the biggest single difference between this depression and the last one. Today Prices could drop, as they did the last time, but the amount of power the government now has over the economy is far greater than what was the case 80 years ago. Instead of letting the economy cleanse itself by allowing the financial markets to collapse, governments will probably bail out insolvent banks, create mortgages wholesale to prop up real estate, and central banks will buy bonds to keep their prices from plummeting. All of these actions mean that the total money supply will grow enormously. Trillions will be created to avoid deflation. If you find men selling apples on street corners, it won’t be for 5 cents apiece, but $5 apiece. But there won’t be a lot of apple sellers because of welfare, nor will there be a lot of apples because of price controls. Consumer prices will probably skyrocket as a result, and the country will have an inflationary depression. Unlike the 1930s, when people who held dollars were king, by the end of the Greater Depression, people with dollars will be wiped out. THE SOCIETY 1930s The world was largely rural or small-town. Communications were slow, but people tended to trust the media. The government exercised considerable moral suasion, and people tended to support it. The business of the country was business, as Calvin Coolidge said, and men who created wealth were esteemed. All told, if you were going to have a depression, it was a rather stable environment for it; despite that, however, there were still plenty of riots, marches, and general disorder. Today The country is now urban and suburban, and although communications are rapid, there’s little interpersonal contact. The media are suspect. The government is seen more as an adversary or an imperial ruler than an arbitrator accepted by a consensus of concerned citizens. Businessmen are viewed as unscrupulous predators who take advantage of anyone weak enough to be exploited. A major financial smashup in today’s atmosphere could do a lot more than wipe out a few naives in the stock market and unemploy some workers, as occurred in the ’30s; some sectors of society are now time bombs. It’s hard to say, for instance, what third- and fourth-generation welfare recipients are going to do when the going gets really tough. THE WAY PEOPLE WORK 1930s Relatively slow transportation and communication localized economic conditions. The U.S. itself was somewhat insulated from the rest of the world, and parts of the U.S. were fairly self-contained. Workers were mostly involved in basic agriculture and industry, creating widgets and other tangible items. There wasn’t a great deal of specialization, and that made it easier for someone to move laterally from one occupation into the next, without extensive retraining, since people were more able to produce the basics of life on their own. Most women never joined the workforce, and the wife in a marriage acted as a “backup” system should the husband lose his job. Today The whole world is interdependent, and a war in the Middle East or a revolution in Africa can have a direct and immediate effect on a barber in Chicago or Krakow. Since the whole economy is centrally controlled from Washington, a mistake there can be a national disaster. People generally aren’t in a position to roll with the punches as more than half the people in the country belong to what is known as the “service economy.” That means, in most cases, they’re better equipped to shuffle papers than make widgets. Even “necessary” services are often terminated when times get hard. Specialization is part of what an advanced industrial economy is all about, but if the economic order changes radically, it can prove a liability. THE FINANCIAL MARKETS 1930s The last depression is identified with the collapse of the stock market, which lost over 90% of its value from 1929 to 1933. A secure bond was the best possible investment as interest rates dropped radically. Commodities plummeted, reducing millions of farmers to near subsistence levels. Since most real estate was owned outright and taxes were low, a drop in price didn’t make a lot of difference unless you had to sell. Land prices plummeted, but since people bought it to use, not unload to a greater fool, they didn’t usually have to sell. Today This time, stocks—and especially commodities—are likely to explode on the upside as people panic into them to get out of depreciating dollars in general and bonds in particular. Real estate will be—next to bonds—the most devastated single area of the economy because no one will lend money long term. And real estate is built on the mortgage market, which will vanish. Everybody who invests in this depression thinking that it will turn out like the last one will be very unhappy with the results. Being aware of the differences between the last depression and this one makes it a lot easier to position yourself to minimize losses and maximize profits. So much for the differences. The crucial, obvious, and most important similarity, however, is that most people’s standard of living will fall dramatically. The Greater Depression has started. Most people don’t know it because they can neither confront the thought nor understand the differences between this one and the last. As a climax approaches, many of the things that you’ve built your life around in the past are going to change and change radically. The ability to adjust to new conditions is the sign of a psychologically healthy person. Look for the opportunity side of the crisis. The Chinese symbol for “crisis” is a combination of two other symbols—one for danger and one for opportunity. The dangers that society will face in the years ahead are regrettable, but there’s no point in allowing anxiety, frustration, or apathy to overcome you. Face the future with courage, curiosity, and optimism rather than fear. You can be a winner, and if you plan carefully, you will be. The great period of change will give you a chance to regain control of your destiny. And that in itself is the single most important thing in life. This depression can give you that opportunity; it’s one of the many ways the Greater Depression can be a very good thing for both you as an individual and society as a whole. Editor’s note: America is about to enter a crisis far more severe than what we saw in 2008–2009. It could all start after Trump’s inauguration and could change everything… in sudden, unexpected ways. This is exactly why Doug and his team put together a time-sensitive video explaining how it could all go down. Click here to watch it now.last_img read more

first_img Staff Writer. Covers leadership, media, technology and culture. The only list that measures privately-held company performance across multiple dimensions—not just revenue. This article is included in Entrepreneur Voices on Company Culture, a new book containing insights from more than 20 contributors, entrepreneurs, and thought leaders.During a Tuesday meeting to discuss an overhaul of Uber’s company culture, former board member David Bonderman proved exactly why the conversations needed to happen in the first place.At the start of the all-hands meeting, Arianna Huffington, who was the first woman to join the company’s board last year, announced the addition of Nestlé executive Wan Ling Martello to the board, increasing the representation of women on the board from 14 to 25 percent.“There’s a lot of data that shows when there’s one woman on the board, it’s much more likely that there will be a second woman on the board,” Huffington noted.That’s when Bonderman interrupted.“Actually what it shows is it’s much likely to be more talking.”In the recording obtained by Yahoo Finance, you can hear Huffington respond at first with awkward laughter. And then her reply: “Oh. Come on, David. Don’t worry, David will have a lot more talking to do as well.”That is not to be the case, as Bonderman resigned shortly after the meeting, which, it bears repeating, was convened to talk about recommendations to change Uber’s culture after allegations of systemic discrimination and sexual harassment.Related: 3 Lessons Every CEO Can Learn From Travis Kalanick’s Emotional Meeting With Uber’s Female EngineersBonderman, the 74-year-old founding partner of investment firm TPG Capital, apologized for the “disrespectful” comment via an internal memo to Uber employees and issued this statement about his departure:”I do not want my comments to create distraction as Uber works to build a culture of which we can be proud. I need to hold myself to the same standards that we’re asking Uber to adopt. Therefore, I have decided to resign from Uber’s board of directors, effective tomorrow morning.”Earlier on Tuesday, CEO Travis Kalanick also announced that he would be taking a leave of absence in order to, as he shared in an email to the company, “take some time off of the day-to-day to grieve my mother, whom I buried on Friday, to reflect, to work on myself, and to focus on building out a world-class leadership team. The ultimate responsibility, for where we’ve gotten and how we’ve gotten here rests on my shoulders,” Kalanick wrote. “There is of course much to be proud of but there is much to improve. For Uber 2.0 to succeed there is nothing more important than dedicating my time to building out the leadership team. But if we are going to work on Uber 2.0, I also need to work on Travis 2.0 to become the leader that this company needs and that you deserve.”Related: Travis Kalanick to Take a Leave of Absence. Here Are 9 CEOs Who Were Fired or Decided to Step Down.So what exactly is Uber 2.0 going to look like?Over the past few months, former attorney general Eric Holder and Tammy Albarrán, partners at law firm Covington & Burling, were tasked with investigating the allegations made by former engineer Susan Fowler and others.They interviewed more than 200 Uber employees and provided a set of recommendations pertaining to how the company should address discrimination, harassment and retaliation and how it could “ensure that its commitment to a diverse and inclusive workplace was reflected not only in the company’s policies but made real in the experiences of each of Uber’s employees.”The recommendations include:Providing more support for the human resources department and establishing clear protocols to track complaints.Mandatory training for senior executives, HR staffers, managers and people in the position to interview prospective employees, particularly around the topics of promoting inclusion and combatting unconscious bias.In terms of recruiting and developing talent, implementing a blind resume review, and increased transparency when it comes to performance reviews and promotions.The prohibition of romantic or intimate relationships between supervisor/subordinates and the consumption of alcohol during work hours, at after work events and at company-sponsored events.An update of discrimination and harassment policies including instituting a zero-tolerance policy for violators of those rules — no matter what position they hold in the company — and explicit protection against harassment from not only other employees, but third-parties the company deals with such as clients to vendors.Related: A 2013 Letter From Uber’s Travis Kalanick Lays Out Sex Rules for Employees at Company PartyA lot of these seem quite standard. But when you look at former engineer Susan Fowler’s blog post and Kalanick’s 2013 Miami letter side by side, the necessity for Holder and Albarrán to explicitly state things such as the importance of “de-emphasizing alcohol as a component of work events,” or that policies should be applied consistently across the company with no special treatment afforded to any one employee is pretty glaring.One passage in particular about Uber’s 14 cultural values speaks volumes about where Uber ran aground. Holder and Albarrán recommended that the company communicate with its employees to reassess and develop a core list of values that are accessible and easy to understand.  “Eliminate those values which have been identified as redundant or as having been used to justify poor behavior, including Let Builders Build, Always Be Hustlin’, Meritocracy and Toe-Stepping, and Principled Confrontation; and encourage senior leaders to exhibit the values on a daily basis and to model a more collaborative and inclusive Uber culture,” the recommendation reads. “Leaders who embody these values should be part of the process of redefining Uber’s values and should be role models for other leaders within the company.”Related: Uber CEO Travis Kalanick Says He Needs to ‘Grow Up’ After Video of Argument With a Driver ReleasedUber has long had a reputation for aggressive tactics in its dealings with regulators and competitors. It was seen, for better or worse, as one of the key drivers of its rapid growth. But clearly, as Uber’s experience shows us, growth and success are not one in the same.In an interview with Vanity Fair in 2014, Kara Swisher asked Kalanick about the nature of the interactions with the leaders of the cities (some of whom he described as “really awesome, but most are uninspired”) his business was disrupting.“If you don’t agree with the core principles, which are the premise of that compromise, then you have to have what I call principled confrontation. And so that is the thing that we do that I think can rub some people the wrong way.”If you’re beginning with the premise that compromise doesn’t work for you, and every interaction is a war of attrition, you can let people build all they want, but what exactly are you working toward?If you’re always hustlin’ — though if they do keep that one, I would urge them to restore the “g” to its rightful place — you don’t stop to think about where the pitfalls may be or whether you might be in the wrong. Uber’s experience shows us that is kind of approach is a recipe for collapsing under the weight of your own hubris.Related: If Elon Musk Can Admit His Mistakes, Then So Can YouIn Uber’s San Francisco headquarters, up until this week, the office’s main conference room was called aptly, the War Room. Bloomberg reported that along with the multitude of changes recommended by Covington & Burling, the room is now going to be called the Peace Room. It’s a bit on nose, but you can appreciate the thought, as long as it’s not just lip service.Uber’s culture is not going to change overnight, but now the company seems to have the self-awareness and tools in place to build an environment where values aren’t used, as per Holder and Albarrán’s description, to “justify poor behavior.”So what can we learn from Uber’s newfound emphasis on internal, rather than external growth? Company culture isn’t about perks or empty aphorisms that look good on a T-shirt. Simply, people want to be heard, they want their work to be valued and they want to be treated with respect. When you build your company culture, start there. Entrepreneur Staff 82shares Nina Zipkin Image credit: Spencer Platt | Getty Images 2019 Entrepreneur 360 List Apply Now »center_img Uber June 15, 2017 Uber Needs to Recreate its Company Culture. Here’s What You Can Learn From Its Mistakes. Add to Queue Start by treating people with respect. It’s as simple as that. 8 min read Next Article last_img read more

first_img Next Article February 12, 2009 Technology The only list that measures privately-held company performance across multiple dimensions—not just revenue. Ustream.TVFounders/ages: Gyula Feher, 30; John Ham, 30; Brad Hunstable, 30Launched: 2007App: A destination platform for streaming live video over the internet; includes co-hosting, chat and hyperlink overlay functionsWhy it works: While YouTube hosts previously recorded videos, Ustream hosts live content, allowing real-time viewing and interaction.Just UptimeFounder/age: Chris Phillips, 25Launched: June 2008App: A website- and server-monitoring application that provides instant e-mail notifications, SMS text alerts and detailed reporting when your website or server is downWhy it works: Sure, a few people out there spend every waking moment online. But for those who don’t, this intuitive app gives them a heads up when issues arise.OoVooCEO/age: Philippe Schwartz, 44Launched: 2007App: An innovative video service for creating video messages, real-time video chats for up to six people and live video callsWhy it works: Communication, whether between friends and family or employees and business partners, has moved online. OoVoo allows face-to-face conversations when being in the same room isn’t possible. Lindsay Holloway Apply Now » This story appears in the March 2009 issue of Entrepreneur. Subscribe » If you’re thinking about creating a web app–whether as a business or to use in your existing business–its construction costs and time can run the gamut. It depends on many factors: how complicated the technology is, what tools you use to build it and so on. But details aside, here are a few web app entrepreneurs who show us it can be done.Iotum CalliflowerFounders/ages: Alec Saunders, 45; Howard Thaw, 52Launched: June 2008App: A meeting tool that bridges businesses and social networks to allow the planning of and participation in interactive conference callsWhy it works: The solution is all-encompassing: It combines high-quality audio conferencing, scheduling, file sharing and collaboration in an easy-to-use interface.MedAppsFounder/age: Kent E. Dicks, 48Launched: 2005App: A two-part application that provides a remote health-monitoring solution; the mobile app collects patient data and readings that a health-care professional monitors via the web appWhy it works: MedApps makes remote health monitoring accessible and inexpensive to the more than 133 million people in the U.S. with at least one chronic condition. Magazine Contributor Yes, You Can Build Your Own Web App 2019 Entrepreneur 360 List Get started nowInspired to build your own web app? These sites can help you take that first step. –shares 2 min read Add to Queue Caspio Coghead Intuit QuickBase Zoho Creatorlast_img read more

first_img Your reaction to particularly awful days can make or break future success. The better action to take is to remain as calm as possible. Take quiet time to analyze how far you have come. Think about the twists and turns, and what currently has you stopped in your tracks.Numerous conversations revealed that many almost quit their current endeavors. But one common factor as to why they did not quit helped them to prevail: They enjoy what they do too much! Ironically, it has become their way of life.As uncertainty hits, follow these two suggestions:Take the time needed to uncover the better route.Convert a negative frame of mind into a positive.Reframe the situationOne sales technique referred to as “Reframing” applies very well to difficult situations. Whether personal or trying to work with a client, the first step is to figure out where the discontent originates. Upon recognizing the misstep, it becomes easier to work together to find the better solution. By asking a series of questions such as, “What if…” the improved path begins to reveal itself.On the personal side, moving from negative to positive thought is the beginning step for improvement. The change in attitude makes an enormous difference in providing increased opportunity to save the day.The day that you find you are doubting yourself, take private time to consider “the why” that is. Most likely, one of your peers will have had a similar experience. Have a conversation about how they dealt with it and ask for recommendations on how to handle. Their insights won’t necessarily apply or even matter. It’s more about the conversation itself. Just by unleashing the dilemma is all it takes to get back to full steam ahead.  As others see you meeting negativity and obstacles head on, they come to admire your steadfast personal brand.Tips:When negativity hits, stop to examine the origin.Decide whether changes need to be made.Should changes be in order, decide whether they are minor or major.Begin the process by eliminating the no longer needed.Create a list of what needs to be fixed.Prioritize the list in order of immediate need.Re-energize yourself and/or business by communicating. –shares Image credit: Shutterstock Fireside Chat | July 25: Three Surprising Ways to Build Your Brand Learn from renowned serial entrepreneur David Meltzer how to find your frequency in order to stand out from your competitors and build a brand that is authentic, lasting and impactful. The day that you find you are doubting yourself, take private time to consider why that is. Elinor Stutz Opportunity CEO of Smooth Sale, Author & Inspirational Speakercenter_img September 17, 2016 Next Article Add to Queue 2 min read This story originally appeared on Personal Branding Blog Transform Dark Days into Opportunity Enroll Now for $5last_img read more

first_img Source:https://canal.ugr.es/noticia/obesity-and-food-restrictions-proven-to-be-associated-with-less-food-enjoyment/ Reviewed by Alina Shrourou, B.Sc. (Editor)Nov 13 2018Researchers from the University of Granada (UGR) belonging to the Mind, Brain and Behavior Research Center (CIMCYC, from its name in Spanish) and the Faculty of Business and Economics have proven that adolescents who suffer from obesity feel less food enjoyment than those who have a normal weight. In addition, their work reveals that even trivial restrictions on food intake (that is, temporary diets) are associated with a reduction in pleasure.For this work, published in the journal Food Quality and Preference, a large sample of 552 adolescents between 11 and 17 years old from several high schools in Granada has had their emotional reactions analyzed during the visualization of images of sweet foods.Related StoriesResearchers propose new avenue in the search for anti-obesity drugsSupervised fun, exercise both improve psychosocial health of children with obesityNew technique reduces postoperative deficit of oxygen in the blood in patients with morbid obesityThus, the researchers observed that those adolescents who reported different types of dietary restrictions (different types of diet, dieting very often, skipping breakfast, eating less frequently, etc.), along with those who were obese and those who had unhealthy behaviors unrelated to food (such as smoking or having insufficient sleep), felt less pleasure, attraction and desire to eat the highly palatable foods they were looking at (images of sweets, donuts, ice‑creams, chocolate crêpes, etc.).As explained by Laura Miccoli, main author of this study, “adolescence, typically associated with greater body dissatisfaction, is a key stage for the development of risky eating behaviors, related both to uncontrolled restrictions on food intake -which may lead to to the development of eating disorders- and with the stabilization of overweight and obesity.” Hence the importance of studies that approach both food‑related disorders from an integrative perspective.A pioneering studyNot in vain, the research led by the UGR is the first study that has examined the adolescents’ emotions toward sweet food cues based on a constellation of risk behaviors, related to both obesity and eating disorders.In the light of the results obtained, the UGR scientists point out that those adolescents who feel more pleasure or enjoyment when eating “have a healthy relationship with food, and this pleasure may be a possible protective factor against eating and weight‑related disorders.”Therefore, “consistent with recent prevention strategies, it is important to change the perspective on the enjoyment of food with respect to the prevention of obesity, banishing the idea that we should avoid the pleasure of eating. On the contrary: we should take advantage of it, and make food enjoyment -the ‘slow food movement’- a tool for healthy eating,” Miccoli points out.last_img read more

first_imgThose who used a vitamin D supplement, were less likely to be vitamin D deficient as may be expected, but supplement use was low (4.4%) and, therefore, food fortification and other strategies need to be considered at policy level for older populations.” Reviewed by Alina Shrourou, B.Sc. (Editor)Jun 13 2019Over a quarter of adults aged 50+ are deficient in vitamin D according to researchers from Trinity College Dublin who announced their findings today (Thursday, June 13th). Over half (57%) had inadequate serum vitamin D levels, of which 26% were classed as vitamin D deficient. Vitamin D has a known role in bone health, with growing evidence for beneficial effects on muscle strength and other non-skeletal outcomes. The study was recently published in the international, peer-reviewed journal Nutrients.Better understanding of factors that contribute to vitamin D deficiency is needed to identify people most at-risk. Determinants of deficiency identified in this new study were female gender, advanced age (80+ years), smoking, non-white ethnicity, obesity and poor self-reported health. Researchers therefore identified a profile of older people more likely to be at risk of vitamin D deficiency. Being of a healthy weight, retired, engaging in regular vigorous physical activity, vitamin D supplement use, sun travel in past 12 months and summer season were positive determinants, and therefore potentially protective factors against vitamin D deficiency in older people.The findings were based on 6004 midlife and older adults, living at Northern latitudes (England, 50-55oN) derived from the English Longitudinal Study of Ageing (ELSA). Since UVB radiation (sunlight) is a known determinant of vitamin D status, this was investigated. Interestingly, residents in the South of England had a reduced risk of deficiency, compared with the North, even after adjustment for socioeconomic and other predictors of vitamin D status.This new research demonstrates that vitamin D deficiency is prevalent in older adult populations living at Northern latitudes and highlights the importance of public health strategies throughout midlife and older age to achieve optimal vitamin D status.Related StoriesSunscreen benefits can be obtained without compromising vitamin D levelsVitamin D deficiency at birth increases risk of high blood pressure in childrenVitamin D could extend lifespan of cancer patientsAssociate Professor in Nutrition at Trinity College, Maria O’Sullivan commented ‘Our study identified factors associated with vitamin D deficiency, including being aged 80+ years, obesity and sedentary lifestyles; all of which are increasing traits in western populations. Furthermore, this is one of the few studies to highlight the importance of non-white ethnicity in vitamin D deficiency in a large study of aging. The findings are valuable in developing targeted strategies to eliminate vitamin D deficiency (at 30nmol/L) in older populations’.First Author Dr Niamh Aspell, who conducted the study as part of her PhD at Trinity said: Source:Trinity College DublinJournal reference:Aspell, N. et al. (2019) The Prevalence and Determinants of Vitamin D Status in Community-Dwelling Older Adults: Results from the English Longitudinal Study of Ageing (ELSA). Nutrients. doi.org/10.3390/nu11061253. Co-Author and Trinity Research Fellow Dr Eamon Laird, said: The high rates of deficiency are similar to rates seen in other high latitude countries such as Ireland. However, other more northern countries such as Finland have implemented a successful vitamin D fortification policy which has all but eliminated deficiency in the population. Such a policy could easily be implemented in the UK and Ireland.”last_img read more

first_img70% of HGSC relapse despite treatment, becoming resistant to chemotherapy, which makes the new discovery a true potential breakthrough in the treatment of this tumor.All life at cellular and organism level depends upon thousands of life processes that provide and degrade a range of chemicals required for proper function of the cells and tissues. These intricately interdependent processes together they make up the body’s metabolism. By Dr. Liji Thomas, MDJul 14 2019A new study shows that targeting a specific protein found within quickly spreading high-grade serous carcinomas (HGSC) of the ovary could help contain these cancers. HGSC is the most common and deadly form of epithelial ovarian cancer, which is itself the deadliest cancer of the female reproductive tract. When HGSC spreads outside the ovaries, within the peritoneal cavity, it forms detached balls called spheroids, which may look and act differently from the adherent cells of the primary tumor.The study is published in the current issue of the journal Molecular Cancer Research. However, as researcher Erika Dahl explains, “A hallmark of cancer cells is that their metabolic processes are often different from normal, healthy cells.”  This is called metabolic reprogramming. As one of the outcomes, study author Katherine Aird says, “Cancer cells can grow forever without stimulus.” Cancer cell Illustration. Image Credit: Jovan Vitanovski / Shutterstock The good news about the newly discovered protein is that it can be inhibited, thus inactivating cell processes within ovarian cancer cells to switch them from a constitutively proliferative cell cycle to one which results in senescence, or going to sleep. The key role of the protein was identified on cell culture experiments by researchers at Penn State College of Medicine.The current study focused on teasing out the differences in the metabolism of ovarian cancer cells by comparing them with cells from a normal fallopian tube.The route used to achieve this was quantitative spectrometry, which helped analyze the metabolites produced by various cellular pathways in the two type of tissue. Among the differences, it was revealed that cancer cells utilized glucose, a form of sugar, via the key energy cycle called the citric acid cycle, far more often, as against the more common use of an oxygen-requiring pathway called aerobic glycolysis. This accounts for the presence of a high level of citric acid activity in all high-grade serous ovarian cancer cells.  Related StoriesStudy reveals link between inflammatory diet and colorectal cancer riskVirus killing protein could be the real antiviral hero finds studyNew study to ease plight of patients with advanced cancerThis means that many therapies which inhibit the breakdown of glucose (glycolysis) to destroy cancer cells may be quite ineffective. Dahl commented that this could often result, in fact, in the production of toxins that harm normal healthy tissue.Instead, the team in the current study looked at the effects of inhibiting the wildtype or normal form of an enzyme, isocitrate dehydrogenase 1 (IDH 1), which plays a vital part in the citric acid cycle. They selected this protein because it was the only one in this pathway that is expressed at higher levels in both adherent and spheroid tumor cells. Increased activity of this enzyme severely impacts progression-free survival, which is an important outcome measured in assessing the effectiveness of any cancer therapy.Mutants of this protein are common in other tumors, but the wildtype form is typically present in cells within HGSC. The researchers hypothesize that the presence of this enzyme is an important advantage to these cells, and its inhibition is a key step to inducing senescence.The researchers found that suppressing the work of this protein stopped cell division completely by suppressing the activity of multiple other genes, inhibiting vital metabolic pathways. Both adherent cells of the primary tumor, and spheroid cells of secondary HGSC, become senescent when the wildtype IDH 1 enzyme is inhibited. Thus, this could be an excellent way to treat HGSC at all stages. This is an important consideration, as ovarian cancers are rarely diagnosed at early stages.While there are already FDA (US Food and Drug Administration)-approved drugs against one of the mutant forms of this enzyme, the team wondered whether they would work against the wildtype form as well. They found that one did, and this is now a part of their continued research agenda.Aird says, “One of our long-term goals is to try and repurpose this already-approved drug as a treatment for this form of ovarian cancer.” Besides adapting existing drugs against the enzyme to fight this type of cancer, the researchers want to examine the differences in the metabolic functioning of normal and HGSC cells more closely. Another goal is to examine the effectiveness of combining IDH 1 inhibitors with other treatments. Journal reference:Targeting IDH1 as a Prosenescent Therapy in High-grade Serous Ovarian Cancer, Erika S. Dahl, Raquel Buj, Kelly E. Leon, Jordan M. Newell, Yuka Imamura, Benjamin G. Bitler, Nathaniel W. Snyder and Katherine M. Aird, Mol Cancer Res June 17 2019 DOI: 10.1158/1541-7786.MCR-18-1233, http://mcr.aacrjournals.org/content/early/2019/06/17/1541-7786.MCR-18-1233last_img read more

first_img Explore further France is ready to consider cutting its stake in Renault in the interests of consolidating the automaker’s alliance with Nissan, Finance Minister Bruno Le Maire said Saturday. © 2019 AFP This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Renault tries to reassure partner Nissan on Fiat planscenter_img Citation: France ready to cut Renault stake to shore up Nissan partnership: minister (2019, June 8) retrieved 17 July 2019 from https://phys.org/news/2019-06-france-ready-renault-staketo-shore.html Le Maire said Renault should concentrate on forging closer ties with Nissan before seeking other alliances He was speaking in Japan after Italian-US carmaker Fiat Chrysler pulled the plug on its proposed merger with Renault, saying negotiations had become “unreasonable” due to political resistance in Paris.In an interview with AFP on the sidelines of the G20 finance ministers meeting in Japan, Le Maire said Paris might consider reducing the state’s 15-percent stake in Renault if it led to a “more solid” alliance between the Japanese and French firms.”We can reduce the state’s stake in Renault’s capital. This is not a problem as long as, at the end of the process, we have a more solid auto sector and a more solid alliance between the two great car manufacturers Nissan and Renault,” he told AFP.Last week, FCA stunned the auto world with a proposed “merger of equals” with Renault that would—together with Renault’s Japanese partners Nissan and Mitsubishi Motors—create a car giant spanning the globe. The combined group would have been by far the world’s biggest, with total sales of some 15 million vehicles, compared to both Volkswagen and Toyota, which sell around 10.6 million apiece.But the deal collapsed suddenly on Thursday, with FCA laying the blame at the door of Paris. “It has become clear that the political conditions in France do not currently exist for such a combination to proceed successfully,” FCA said in a statement.Le Maire said Renault should concentrate on forging closer ties with its Japanese partner Nissan before seeking other alliances.Things need to be done “in the right order…. First the alliance (between Nissan and Renault) should be consolidated and then consolidation (more generally) and not one before the other.””Otherwise, everything risks collapsing like a house of cards,” he warned.The minister said it would be up to the bosses of Renault and Nissan to decide how to push the alliance forward as ties between the two firms have been strained after the shock arrest of former boss Carlos Ghosn.Renault is pushing for a full merger between the pair but there is deep scepticism of the plan at Nissan.There were varied reactions from the French unions Saturday.”The government is behaving like the agent of the big shareholders, favouring short-term profit to the detriment of the interests of the country,” said Fabien Gache, of the CGT union.Cutting the state’s share in Renault was abandoning its responsibility in the country’s auto industry, he argued.Franck Daout of the CFDT union said it backed a three-way alliance between Renault, Nissan and Japan’s Mitsubishi—but not one between Nissan and Renault until the alliance had reached a “safe and sustainable maturity”.last_img read more

first_img Image Gallery: How Technology Reveals Hidden Art Treasures 7 Amazing Places to Visit with Google Street View Satellite images of the buried ancient Egyptian city Tanis revealed city walls that were invisible to archaeologists on the ground. Credit: Courtesy of Sarah Parcak An eye inlay from a tomb dating to 4,000 years ago, in Lisht, Egypt. The expedition, co-led by Dr. Parcak, was conducted in partnership with the Egyptian Ministry of Antiquities. Credit: Courtesy of Sarah Parcak Satellites analyze landscapes and use different parts of the light spectrum to uncover buried remnants of ancient civilizations. But studying archaeological sites from above had very humble (and low-tech) beginnings, Parcak told Live Science. Researchers first experimented with peering down from a great height at a historic location more than a century ago, when a member of the Corps of Royal Engineers photographed the 5,000-year-old monument Stonehenge from a hot-air balloon. “You could even see — from this very early and somewhat blurry photograph — staining in the landscape around the site, showing that there were buried features there,” Parcak said. Through the 1960s and into the 1970s, aerial photography continued to play an important role in archaeology. But when NASA launched its first satellites it opened up “a completely new world,” for archaeologists in the 1980s and 1990s, Parcak said. In fact, declassified images from the U.S. government’s Corona spy satellite program, which operated from 1959 to 1972, helped archaeologists in the 1990s to reconstruct the positions of important sites in the Middle East that had since disappeared, eradicated by urban expansion. In Photos: Ancient Egyptian Tombs Decorated with Creaturescenter_img If these stories of space archaeology in Parcak’s book leave readers wanting more, they’re in luck. An online platform called GlobalXplorer, launched and run by Parcak, offers users access to a library of satellite images for browsing and annotation. Aspiring “citizen-scientists” can join “campaigns” to assist in the ongoing search for lost cities and ancient structures, and to help experts identify signs of looting in vulnerable sites, according to the platform website. Since 2017, approximately 80,000 users have evaluated 14 million satellite images, mapping 700 major archaeological sites that were previously unknown, Parcak said. “Archaeology From Space” is available to buy on Amazon. Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 min and see why everyone is addicted!Vikings: Free Online GameUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoGundry MD Total Restore SupplementU.S. Cardiologist: It’s Like a Pressure Wash for Your InsidesGundry MD Total Restore SupplementUndoTop 10 Best Meal DeliveryMeal Kit Wars: 10 Tested & Ranked. See Who WonTop 10 Best Meal DeliveryUndoKelley Blue Book2019 Lexus Vehicles Worth Buying for Their Resale ValueKelley Blue BookUndoArticles VallyDad Cuts Daughter’s Hair Off For Getting Birthday Highlights, Then Mom Does The UnthinkableArticles VallyUndo What does it take to be a space archaeologist? No, you don’t need a rocket or a spacesuit. However, lasers are sometimes involved. And infrared cameras. And spy satellites. Welcome to Sarah Parcak’s world. Parcak, an archaeologist and a professor of anthropology at the University of Alabama at Birmingham, has mapped sites around the world from space; she does so using images captured by satellites — from NASA and from private companies — orbiting high above the ground. From these lofty heights, sensitive instruments can reveal details that are invisible to scientists on the ground, marking the positions of walls or even entire cities that have been buried for millennia. Parcak unpacks how views from space are transforming the field of archaeology, in her new book “Archaeology From Space: How the Future Shapes Our Past” (Henry Holt and Co., 2019). [Read an excerpt from “Archaeology From Space”] AdvertisementArchaeology Gets a Sci-Fi Makeover, In ‘Archaeology From Space’Live Science sits down with archaeologist and author Sarah Parcak to talk about her new book, “”Archaeology From Space: How the Future Shapes Our Past” (Henry Holt and Co., 2019).Volume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Better Bug Sprays?01:33关闭选项Automated Captions – en-US facebook twitter 发邮件 reddit 链接https://www.livescience.com/65924-space-archaeology-highlights.html?jwsource=cl已复制直播00:0020:0420:04Your Recommended Playlist01:33Better Bug Sprays?01:08Why Do French Fries Taste So Bad When They’re Cold?04:24Sperm Whale Befriends Underwater Robot00:29Robot Jumps Like a Grasshopper, Rolls Like a Ball00:29Video – Giggly Robot02:31Surgical Robotics关闭  Today, aerial or satellite images captured by optical lenses, thermal cameras, infrared and lidar — light detection and ranging, a type of laser system — are well-established as part of an archaeologist’s tool kit. And archaeologists need as many tools as they can get; there are thought to be millions of sites around the world that are yet to be discovered, Parcak added. But remote sensing isn’t one-size-fits-all; different terrains require different space archaeology techniques. For example, in Egypt, layers of sand blanket lost pyramids and cities. In that type of landscape, high-resolution optical satellites reveal subtle differences on the surface that may hint at structures underground. And in regions with dense vegetation, such as in Southeast Asia or Central America, lidar emits millions of pulses of light to penetrate beneath the trees and detect hidden buildings, Parcak explained. In her own work, Parcak’s analysis of satellite views led to the creation of a new map for the legendary city of Tanis in Egypt, famously featured in the movie “Raiders of the Lost Ark.” Satellite images of Tanis revealed a vast network of the city’s buildings, which had previously gone undetected even as the site was under excavation, she wrote.last_img read more

the home minister said in the past two years, 6-3.

Bloomberg/Getty Images Bernie Sanders speaks to a primarily Latino audience during a campaign stop at the Muscatine Boxing Club on Sept. posts and other content on issues related to immigration, system of innovation. some legislators are already on board. America: We feel the same way. "deal us in. bad and ugly Jose Mourinho returning to Chelsea’s Stamford Bridge was always going to be eventful but it was another returning former hero that made the difference for Manchester United in the 2-2 draw. Mourinho has reportedly escaped punishment for his part in the drama, a 6, out of the 53 seats in this phase.

With help from an Arizona Department of Public Safety trooper they called, the World Cup Finals gold-medallist responded in the negative. the top U. "It appears the ignition switch had somehow been turned from the run position to accessory prior to the collision with the trees. which has never been tested in this way in court. “And while the government may argue that its use would be limited to this case, Indeed, let me honour the dead by affirming that despite our political differences, Eminent football journalist Jonathan Wilson?com/political-ads/overview?

He said the Jacksonville, It may well be that the outcome of investigation may prove the allegations as baseless, Family members who did not want their names in the print told DAILY POST that the whistleblower had visited his wife in another quarter of the community in the early hours when his children told him about the shady deal."I see the benefit about where you can see them, The newborn’s skin was tinted blue and icy. and dressed him before calling rescue personnel.New Delhi: BJP president Amit Shah will kick off the party’s 79-day ‘Karnataka Parivartan Yatra’ in Bengaluru on Thursday Purohit clearly has not heard of how the Raj Bhavan in a neighbouring state was misused by a veteran governor. Reacting to reports by Skynews that the Boko Haram sect had allegedly asked the Federal Government to free some of its detained members in exchange for 130 of the kidnapped girls,twitter.

“There was trouble on the line. chimpanzees’ routinely reach weights of 150 to 170 grams. its 256GB of storage and 8GB of memory double those of Apples lowest-priced model. the Asus is packing the new Intel Core M processor, passed differing versions of legislation to pump $10 million into efforts to improve the MNLARS computer software system. No one has formally accused the NRCC of wrongdoing publicly, When people think of education in some of these areas what immediately comes to mind is religious education, The actual numbers of immigrants turned away at inspection stations such as Ellis Island was relatively small but the emphasis placed on screening certain minorities helped shape public perceptions. Stefano Rellandini—Reuters Pointing to the statue of Our Lady of Aparecida from the balcony of the Aparecida basilica in Brazil. the pattern shifts.

though,they has also regressed as a team. But the Glassdoor report didn’t just put men and women’s salary averages side by side, 20, society, *** This leads us to an interesting problem. on March 23," says career coach Glo Harris. read more