first_imgNYC & Company joined with Heritage of Pride, organisers of NYC Pride to formally announce the two-year countdown to WorldPride 2019. Set to take place in New York City in June 2019, the global celebration of Pride will coincide with the historic 50th anniversary of the Stonewall Riots—the birthplace of the modern gay rights movement making it a year to underscore New York City’s progress and resilience as a global LGBTQ capital.A new invitational campaign, titled ‘One World, One Pride, One New York City– Unite in 2019’ was launched in New York City.Mayor Bill de Blasio, said, “As a city with such a rich history of fighting inequality and an unwavering dedication to social progress, we are thrilled to host WorldPride 2019. I can think of no better time to celebrate the LGBTQ community than on the 50th anniversary of Stonewall—a seminal moment in the struggle for inclusion and human rights that has reverberated across the country for decades.Fred Dixon, NYC & Company President and CEO, said, “New York City is one of the world’s most iconic LGBTQ destinations, and we look forward to taking the baton from Madrid as we begin the two-year countdown to WorldPride 2019. To have this extraordinary event in New York City coinciding with the 50th anniversary of Stonewall makes it that much more meaningful as we welcome the world and celebrate the continued progress of our city’s LGBTQ community.”During the 2019 WorldPride celebration in New York City, NYC Pride will feature its own ‘Millions of Moments of Pride’ campaign. The initiative is based on the premise that everyone remembers their first Pride and everyone has their own unique Pride story to share.last_img read more

first_imgTesco, the UK’’s largest retailer, has started testing its Club Card TV streaming service and is expected to roll it out to its customers soon.The over-the-top service is in beta test mode and only available to Tesco employees. It is being run by Blinkbox, the streaming service that Tesco acquired in 2011.The Club Card programming line-up will include TV series and movies and there is content from Warner Bros. and the BBC among others.TV series include BBC comedy series Goodness Gracious Me and Two Pints of Lager and a Packet of Crisps and Electric Sky-distributed fashion series Fashion Avenue. There are also animated kids series including Care Bears and Justice League.Movie titles include Mazes and Monsters and Cheesecake Casserole. There are also kids animated titles including Superman: Brainiac Attacks and The Return of the King.The service will be free for Tesco customers who are part of the Club Card loyalty scheme. Consumers without a Club Card can get one free of charge and then access Club Card TV.Tesco is the largest retailer in the UK with a nationwide network of supermarkets. It also offers financial and other services under the Tesco brand.last_img read more

first_imgKenya-based Econet Media has launched a free-to-air sports channels that will offer coverage of English Premier League football as well as NBA basketball, Extreme Fighting Championship combat sports and NFL American football.The channel, Kwesé Free Sports, will be available on digital-terrestrial TV and on satellite in Kenya via free-to-air set-top boxes.The channel has exclusive free-to-air rights to air one Premier League match of the week every Saturday.Kenyan content on the channel includes Xtreme Outdoor Africa, Ball N’Africa and Sports Stars Uncovered.Econet Media is a unit of Econet Wireless, a mobile telecommunications operator founded by Zimbabwean businessman Strive Masiyiwa. Masiwiya revealed at the end of last year that he was planning to launch a broader pay TV service called Kwesé TV, offering a mix of sports and entertainment programming across sub-Saharan Africa, including to mobile users.He said that the company’s satellite unit, Liquid Sat, had built a platform to deliver the service via DTH.“We are thrilled to have reached this important milestone. Our goal is to bring African viewers the very best viewing experience and we are able to provide this for free in a way that is accessible for our viewers,” said Ben Amadasun, CEO Kwesé Free Sports.“Not only will we air local content, but we will also commission the production of original work by local production companies, as part of our commitment to developing the local industry”, said Monicah Ndungu general manager of the channel.last_img read more

first_imgJames PurnellThe BBC has called for on-demand players like its iPlayer service to be guaranteed prominence on all major TV platforms.In a article for the Telegraph ahead of a House of Lords debate on the issue this week, the BBC’s director, radio and education, James Purnell, said it is important that content from the BBC and other public service broadcasters can be easily found in an increasingly digital age.“Fourteen years ago, Parliament took a far-sighted decision. It insisted that the public service channels including BBC One, ITV and Channel 4 should be at the top of the programme guides on all TV platforms,” said Purnell.“It made our channels easy to find – especially important for the BBC, whose programmes people have already paid for via their licence fee. But the world has changed, with the rapid growth of digital channels and new services.”He said that the new generation of set-top boxes have a limited number of content options on their home pages and that if those places are filled by content from the platform owners like Sky, or from Netflix, Amazon or YouTube, “that leaves little room for the on-demand services from our public service broadcasters”.“Some pay-TV platforms are already making ‘free to air’ services harder to find. On the new Sky box, Sky Q, there is no one button on the remote control that takes you to live TV, the single most popular thing Sky customers do. Instead, ‘Home’ takes you to Top Picks – a set of recommended programmes chosen by Sky,” he complained.Purnell also argued that the BBC’s children’s channels, CBeebies and CBBC, should be moved up the Sky EPG, as they are currently listed behind 12 US cartoon networks.A Sky spokesperson described Purnell’s comments as “blatant self-interest”, adding that “for many years we’ve provided the top five slots on the programme guide to public service broadcasters, making them easily accessible.”last_img read more

first_img“We are on the cusp of curing aging.” Those are the words of molecular biologist Dr. William Andrews, founder and CEO of Sierra Sciences, a company with the stated goal to “cure aging or die trying.” In the quote above, which comes from a September 2010 Sierra Sciences press release, Andrews is referring to a nutraceutical (i.e., a natural food-derived product meant to provide health or medical benefits, like vitamin C or folic acid) that his company discovered, known as TA-65. It supposedly slows down the aging process in humans by activating an enzyme called telomerase. Telomerase acts on telomeres—simple repeating sequences of nucleotides (the building blocks of DNA) found at the tips of chromosomes that are important to cell division and replication. Cells must replicate their genes accurately and completely whenever they divide, or the so-called daughter cell will malfunction and die. However, most DNA polymerases (the enzymes that replicate DNA) cannot copy chromosomes all the way to the end. Thus, during each cell division, a small region at the tip of the chromosome (part of the telomere) remains uncopied. So, the telomeres have a crucial function: they act as a buffer zone during cell division, protecting the genes in the chromosome and ensuring that they fully replicate. But there’s a cost: successive divisions cause the telomeres to erode over time. When telomeres erode away, parts of critical genes remain uncopied, eventually spelling death for the cell. Some scientists think that this telomere erosion is what imposes a limit on our lifespans and causes our health to decline as we age; they also think that an answer to this dilemma might be telomerase activation. Telomerase combats telomere erosion by adding telomeric subunits (repeating sequences of nucleotides) to the ends of the chromosome, thereby allowing it to continue to divide intact. The origin of telomerase still remains a mystery. It appears to be critical during human embryonic development, but then fades away. Little is found in the body after birth, for reasons we don’t yet understand. Some scientists, like Dr. Andrews, think telomerase activation could be the cure for aging that his company is looking for, and he views TA-65 as a potential big first step in that direction. According to Andrews: TA-65 is going to go down in history as the first supplement you can take that doesn’t merely extend your life a few years by improving your health, but actually affects the underlying mechanisms of aging. Better telomerase inducers will be developed in the coming years, but TA-65 is the first of a whole new family of telomerase-activating therapies that could eventually keep us young and healthy forever. Well, if proven true, that’s a game-changer, to say the least. Just keep on living until you meet with a fatal accident. Woo hoo! But… hold on. Turns out we shouldn’t get irrationally exuberant just yet. It might not be such a good idea to activate telomerase, after all—because of the role it seems to play in cancer. Cancers can arise when genetic mutations inside a cell cause it to escape from normal controls on replication and migration. The cell and its offspring multiply uncontrollably while invading and damaging nearby tissue. With the presence of telomerase, cancerous cells—which apparently synthesize the enzyme—avoid telomere erosion. They essentially become immortal, dividing for as long as the host survives. A 2012 study by the MD Anderson Cancer Center found that activating telomerase following telomere degradation actually made tumors stronger and more deadly. So alas, TA-65 and telomerase activation might not be the miracle aging “cure” Dr. Andrews was hoping for. But what about other areas of anti-aging/longevity research? There’s a lot of talk these days about humans becoming essentially immortal in the near future, but is the hype supported by any actual research? Let’s see. The Quest for Immortality Continues People have been obsessed with the idea of immortality and living forever for centuries. According to Adam Gollner in The Book of Immortality: The Science, Belief, and Magic Behind Living Forever: The twenty-five-year old Emperor Ai of Jin died in 365 CE, after overdosing on longevity drugs. He wasn’t the last leader to die trying to live forever. The fascination with chemical immortality reached an ironic apogee centuries later, during the T’ang dynasty (618-907 CE), when elixirs poisoned those hoping for precisely the opposite effect. In the late 1300s, legend has it that alchemist Nicolas Flamel created a “sorcerer’s stone” that was then used to produce a potion, the elixir of life, which is said to make the drinker immortal. The idea was so alluring that despite a complete lack of evidence to support the existence of the stone and the elixir, other scientists, including the great Sir Isaac Newton, later tried to replicate Flamel’s results. To no avail. And of course there’s the fabled Fountain of Youth that became associated with Spanish explorer Ponce de León in the early 1500s. We know what happened to him. People today are no different. Not wanting to die is as natural as life itself. Below we’ll present a few interesting discoveries that may (or may not) mark some progress in our quest to live forever. But first we must answer a question. What Is Anti-Aging Medicine? The telomere erosion we talked about earlier certainly plays a part in aging, but most scientists don’t believe that it’s the only factor. They typically view aging as a sort of ongoing cellular wear and tear, where stresses from the environment and inside our cells (such as errors in DNA replication) accumulate throughout life and eventually wear out our cells and tissues. Scientists who search for a modern anti-aging elixir seek to slow down or reverse this process in order to extend both the maximum and average lifespan of people. And even if that doesn’t pan out, advocates of anti-aging medicine contend that at the least, targeting and altering the underlying mechanisms of aging will bring us more efficient ways to deal with age-related conditions like heart disease and many cancers. Now critics dispute the portrayal of aging itself as a disease, of course, but that’s not for us to debate here. Let’s just agree with the commonly stated goal of anti-aging medicine, to “add more years to your life, and life to your years.” Caloric Restriction Mimetics In 1934, scientists at Cornell University found that mice on an abnormally low-calorie diet lived about twice as long as mice who ate as much as they wanted. Scientists have since found that this caloric restriction also lengthens the lives of fruit flies, rats, and even primates, suggesting that this is an avenue worth pursuing in anti-aging medicine. The going (very basic) hypothesis of why these animals live longer is that their bodies treat food scarcity as an extreme type of stress. So they mount a physiological response to cope with the lack of nutrition. And that toughens them up, promoting health and longevity during the time of deprivation, even if that time is significantly extended. Starving yourself in order to get stronger? That sure seems counterintuitive. But the results from numerous experiments make a compelling case. The problem with caloric restriction is that it’s not a very pleasant way to live if you’re fortunate enough to be able to consume a “normal” amount of food on a regular basis (which is between 2,400 and 3,000 calories a day for active males). So scientists are trying to develop drugs (called caloric restriction mimetic drugs) that re-create the anti-aging benefits of caloric restriction without having to change one’s diet. Resveratrol, which is found in the skin of red grapes, was an early favorite in this category. It was first thought to activate a class of enzymes called sirtuins that have been associated with the anti-aging benefits of caloric restriction; but more recent studies have raised serious doubts about whether this compound (and more potent versions of it) actually activates these enzymes and has life-extending benefits. A drug called rapamycin has shown more promise as a caloric restriction mimetic by inhibiting a molecular signaling pathway called TOR. The TOR pathway acts as sort of as a food sensor and helps regulate the body’s response to nutrient availability. Blocking it has been shown on multiple occasions to extend the lifespan of lab knockout mice while keeping them lean and healthy in their later years. Unfortunately, however, the drug’s anti-aging potential in humans is offset by its potent immunosuppressant effects. Overall, research in this field has a long way to go. NAD As we noted above, aging is a sort of cellular wear and tear. According to Dr. David Sinclair of Harvard Medical School, there’s a specific biological signal that accompanies aging and tells cells it’s time to check out. It’s triggered when the cell perceives a lack of oxygen. That makes the mitochondria less efficient at converting fuel (such as glucose) into the ATP needed for cells to function properly. But Sinclair and his colleagues recently found a way to counteract that signal. Using a natural chemical compound called NAD, they were able to revive older cells in mice and make them appear energetic and young again. After receiving NAD for just one week, two-year-old mice tissue came to resemble that of six-month-old mice. “When we give the molecule, the cells think oxygen levels are normal and everything revs back up again,” Sinclair explained. “If a body is slowly falling apart and losing the ability to regulate itself effectively, we can get it back on track to what it was in its 20s and 30s.” Let’s hope. FOXO Molecular biologist Cynthia Kenyon thinks she may have found another of the keys to a long life through her study of tiny worms called C. elegans. By tweaking just one gene in these worms (to simply make it more active), she was able to take two-week-old C. elegans (which is a creaky old age for these things) and make them appear about half that age. And her modified worms lived twice as long as the normal worms. “So they’re like 90-year-old people who look 45,” said Kenyon. The gene Kenyon changed: FOXO. FOXO is a sort of master gene that helps C. elegans protect and repair its tissues (and live longer) by controlling a number of other genes. According to Kenyon: You can think of it as a superintendent of a building. So if you have a building, a nice big building, obviously it has to be maintained. What FOXO does, or the building superintendent does, is to keep the building in good working order. It makes sure that the walls are painted, by hiring painters; it makes sure that the floors are swept. The building superintendent would hire workers to do these different things. What FOXO does, in the cell, is it switches on other genes … I’d say, altogether, there are probably about a hundred worker genes that have very important roles. And, together, what you get is a cell or tissue or an animal that stays in really good working condition for a lot longer. What’s particularly exciting about Kenyon’s work is that the FOXO gene is also found in humans, and that a more protective version of FOXO (as in Kenyon’s modified worms) is associated with longer, healthier lives. Molecular biologist Timothy Donlon found in his studies that if you have this more protective version of FOXO, you have a twofold greater chance of living to 100. And if you have two copies of it, you have a threefold greater chance of living to 100, while remaining healthy. So the gene is indeed associated with adding life to your years and years to your life. If scientists could create a drug to tweak FOXO in humans like Kenyon did in her worms, it seems like we’d have an effective anti-aging medicine on our hands. We could go on with other examples of promising research in anti-aging medicine, but that’s a reasonable sample. It’s the ultimate area of scientific research, really. Moreover, it seems likely to bring benefits to humankind (and also be lucrative for savvy investors) whether aging is a disease that can be “cured” or not. And before leaving you today, I do want to remind you once more about the opportunity to get in on Casey OnePass. It’s just open until Monday, and it’s your only chance to get all eight of our newsletters for a huge discount. Click here to learn more and get started.last_img read more

first_img[dropcap]W[/dropcap]elcome to Starters Orders. Our daily midday update from the trading room at Star Sports with our key market movers for the day across all sports.Friday 25 MarchRACING2.40 LingfieldMoonrise Landing 2/1 > 6/42.55 WolverhamptonGang Warfare 4/1 > 3/13.30 WolverhamptonDavarde 10/1 > 6/15.00 WolverhamptonRainford Glory 14/1 > 7/1LIVE FOOTBALLNational League15:00 BT Sport 1 / BT Sport 1 HD4/5 Tranmere Rovers 7/2 Lincoln City 5/2 DRAWLeague One17:30 Sky Sports 1 / Sky Sports 1 HD13/5 Swindon Town 21/20 Wigan Athletic 5/2 DRAWLeague One19:45 Sky Sports 1 / Sky Sports 1 HD11/8 Peterborough United 19/10 Coventry City 12/5 DRAW(All prices subject to fluctuation) What’s your view?CALL STAR SPORTS ON 08000 521 321last_img read more

first_img Staff Writer. Covers leadership, media, technology and culture. The only list that measures privately-held company performance across multiple dimensions—not just revenue. This article is included in Entrepreneur Voices on Company Culture, a new book containing insights from more than 20 contributors, entrepreneurs, and thought leaders.During a Tuesday meeting to discuss an overhaul of Uber’s company culture, former board member David Bonderman proved exactly why the conversations needed to happen in the first place.At the start of the all-hands meeting, Arianna Huffington, who was the first woman to join the company’s board last year, announced the addition of Nestlé executive Wan Ling Martello to the board, increasing the representation of women on the board from 14 to 25 percent.“There’s a lot of data that shows when there’s one woman on the board, it’s much more likely that there will be a second woman on the board,” Huffington noted.That’s when Bonderman interrupted.“Actually what it shows is it’s much likely to be more talking.”In the recording obtained by Yahoo Finance, you can hear Huffington respond at first with awkward laughter. And then her reply: “Oh. Come on, David. Don’t worry, David will have a lot more talking to do as well.”That is not to be the case, as Bonderman resigned shortly after the meeting, which, it bears repeating, was convened to talk about recommendations to change Uber’s culture after allegations of systemic discrimination and sexual harassment.Related: 3 Lessons Every CEO Can Learn From Travis Kalanick’s Emotional Meeting With Uber’s Female EngineersBonderman, the 74-year-old founding partner of investment firm TPG Capital, apologized for the “disrespectful” comment via an internal memo to Uber employees and issued this statement about his departure:”I do not want my comments to create distraction as Uber works to build a culture of which we can be proud. I need to hold myself to the same standards that we’re asking Uber to adopt. Therefore, I have decided to resign from Uber’s board of directors, effective tomorrow morning.”Earlier on Tuesday, CEO Travis Kalanick also announced that he would be taking a leave of absence in order to, as he shared in an email to the company, “take some time off of the day-to-day to grieve my mother, whom I buried on Friday, to reflect, to work on myself, and to focus on building out a world-class leadership team. The ultimate responsibility, for where we’ve gotten and how we’ve gotten here rests on my shoulders,” Kalanick wrote. “There is of course much to be proud of but there is much to improve. For Uber 2.0 to succeed there is nothing more important than dedicating my time to building out the leadership team. But if we are going to work on Uber 2.0, I also need to work on Travis 2.0 to become the leader that this company needs and that you deserve.”Related: Travis Kalanick to Take a Leave of Absence. Here Are 9 CEOs Who Were Fired or Decided to Step Down.So what exactly is Uber 2.0 going to look like?Over the past few months, former attorney general Eric Holder and Tammy Albarrán, partners at law firm Covington & Burling, were tasked with investigating the allegations made by former engineer Susan Fowler and others.They interviewed more than 200 Uber employees and provided a set of recommendations pertaining to how the company should address discrimination, harassment and retaliation and how it could “ensure that its commitment to a diverse and inclusive workplace was reflected not only in the company’s policies but made real in the experiences of each of Uber’s employees.”The recommendations include:Providing more support for the human resources department and establishing clear protocols to track complaints.Mandatory training for senior executives, HR staffers, managers and people in the position to interview prospective employees, particularly around the topics of promoting inclusion and combatting unconscious bias.In terms of recruiting and developing talent, implementing a blind resume review, and increased transparency when it comes to performance reviews and promotions.The prohibition of romantic or intimate relationships between supervisor/subordinates and the consumption of alcohol during work hours, at after work events and at company-sponsored events.An update of discrimination and harassment policies including instituting a zero-tolerance policy for violators of those rules — no matter what position they hold in the company — and explicit protection against harassment from not only other employees, but third-parties the company deals with such as clients to vendors.Related: A 2013 Letter From Uber’s Travis Kalanick Lays Out Sex Rules for Employees at Company PartyA lot of these seem quite standard. But when you look at former engineer Susan Fowler’s blog post and Kalanick’s 2013 Miami letter side by side, the necessity for Holder and Albarrán to explicitly state things such as the importance of “de-emphasizing alcohol as a component of work events,” or that policies should be applied consistently across the company with no special treatment afforded to any one employee is pretty glaring.One passage in particular about Uber’s 14 cultural values speaks volumes about where Uber ran aground. Holder and Albarrán recommended that the company communicate with its employees to reassess and develop a core list of values that are accessible and easy to understand.  “Eliminate those values which have been identified as redundant or as having been used to justify poor behavior, including Let Builders Build, Always Be Hustlin’, Meritocracy and Toe-Stepping, and Principled Confrontation; and encourage senior leaders to exhibit the values on a daily basis and to model a more collaborative and inclusive Uber culture,” the recommendation reads. “Leaders who embody these values should be part of the process of redefining Uber’s values and should be role models for other leaders within the company.”Related: Uber CEO Travis Kalanick Says He Needs to ‘Grow Up’ After Video of Argument With a Driver ReleasedUber has long had a reputation for aggressive tactics in its dealings with regulators and competitors. It was seen, for better or worse, as one of the key drivers of its rapid growth. But clearly, as Uber’s experience shows us, growth and success are not one in the same.In an interview with Vanity Fair in 2014, Kara Swisher asked Kalanick about the nature of the interactions with the leaders of the cities (some of whom he described as “really awesome, but most are uninspired”) his business was disrupting.“If you don’t agree with the core principles, which are the premise of that compromise, then you have to have what I call principled confrontation. And so that is the thing that we do that I think can rub some people the wrong way.”If you’re beginning with the premise that compromise doesn’t work for you, and every interaction is a war of attrition, you can let people build all they want, but what exactly are you working toward?If you’re always hustlin’ — though if they do keep that one, I would urge them to restore the “g” to its rightful place — you don’t stop to think about where the pitfalls may be or whether you might be in the wrong. Uber’s experience shows us that is kind of approach is a recipe for collapsing under the weight of your own hubris.Related: If Elon Musk Can Admit His Mistakes, Then So Can YouIn Uber’s San Francisco headquarters, up until this week, the office’s main conference room was called aptly, the War Room. Bloomberg reported that along with the multitude of changes recommended by Covington & Burling, the room is now going to be called the Peace Room. It’s a bit on nose, but you can appreciate the thought, as long as it’s not just lip service.Uber’s culture is not going to change overnight, but now the company seems to have the self-awareness and tools in place to build an environment where values aren’t used, as per Holder and Albarrán’s description, to “justify poor behavior.”So what can we learn from Uber’s newfound emphasis on internal, rather than external growth? Company culture isn’t about perks or empty aphorisms that look good on a T-shirt. Simply, people want to be heard, they want their work to be valued and they want to be treated with respect. When you build your company culture, start there. Entrepreneur Staff 82shares Nina Zipkin Image credit: Spencer Platt | Getty Images 2019 Entrepreneur 360 List Apply Now »center_img Uber June 15, 2017 Uber Needs to Recreate its Company Culture. Here’s What You Can Learn From Its Mistakes. Add to Queue Start by treating people with respect. It’s as simple as that. 8 min read Next Article last_img read more

first_img Next Article February 12, 2009 Technology The only list that measures privately-held company performance across multiple dimensions—not just revenue. Ustream.TVFounders/ages: Gyula Feher, 30; John Ham, 30; Brad Hunstable, 30Launched: 2007App: A destination platform for streaming live video over the internet; includes co-hosting, chat and hyperlink overlay functionsWhy it works: While YouTube hosts previously recorded videos, Ustream hosts live content, allowing real-time viewing and interaction.Just UptimeFounder/age: Chris Phillips, 25Launched: June 2008App: A website- and server-monitoring application that provides instant e-mail notifications, SMS text alerts and detailed reporting when your website or server is downWhy it works: Sure, a few people out there spend every waking moment online. But for those who don’t, this intuitive app gives them a heads up when issues arise.OoVooCEO/age: Philippe Schwartz, 44Launched: 2007App: An innovative video service for creating video messages, real-time video chats for up to six people and live video callsWhy it works: Communication, whether between friends and family or employees and business partners, has moved online. OoVoo allows face-to-face conversations when being in the same room isn’t possible. Lindsay Holloway Apply Now » This story appears in the March 2009 issue of Entrepreneur. Subscribe » If you’re thinking about creating a web app–whether as a business or to use in your existing business–its construction costs and time can run the gamut. It depends on many factors: how complicated the technology is, what tools you use to build it and so on. But details aside, here are a few web app entrepreneurs who show us it can be done.Iotum CalliflowerFounders/ages: Alec Saunders, 45; Howard Thaw, 52Launched: June 2008App: A meeting tool that bridges businesses and social networks to allow the planning of and participation in interactive conference callsWhy it works: The solution is all-encompassing: It combines high-quality audio conferencing, scheduling, file sharing and collaboration in an easy-to-use interface.MedAppsFounder/age: Kent E. Dicks, 48Launched: 2005App: A two-part application that provides a remote health-monitoring solution; the mobile app collects patient data and readings that a health-care professional monitors via the web appWhy it works: MedApps makes remote health monitoring accessible and inexpensive to the more than 133 million people in the U.S. with at least one chronic condition. Magazine Contributor Yes, You Can Build Your Own Web App 2019 Entrepreneur 360 List Get started nowInspired to build your own web app? These sites can help you take that first step. –shares 2 min read Add to Queue Caspio Coghead Intuit QuickBase Zoho Creatorlast_img read more

first_img Your reaction to particularly awful days can make or break future success. The better action to take is to remain as calm as possible. Take quiet time to analyze how far you have come. Think about the twists and turns, and what currently has you stopped in your tracks.Numerous conversations revealed that many almost quit their current endeavors. But one common factor as to why they did not quit helped them to prevail: They enjoy what they do too much! Ironically, it has become their way of life.As uncertainty hits, follow these two suggestions:Take the time needed to uncover the better route.Convert a negative frame of mind into a positive.Reframe the situationOne sales technique referred to as “Reframing” applies very well to difficult situations. Whether personal or trying to work with a client, the first step is to figure out where the discontent originates. Upon recognizing the misstep, it becomes easier to work together to find the better solution. By asking a series of questions such as, “What if…” the improved path begins to reveal itself.On the personal side, moving from negative to positive thought is the beginning step for improvement. The change in attitude makes an enormous difference in providing increased opportunity to save the day.The day that you find you are doubting yourself, take private time to consider “the why” that is. Most likely, one of your peers will have had a similar experience. Have a conversation about how they dealt with it and ask for recommendations on how to handle. Their insights won’t necessarily apply or even matter. It’s more about the conversation itself. Just by unleashing the dilemma is all it takes to get back to full steam ahead.  As others see you meeting negativity and obstacles head on, they come to admire your steadfast personal brand.Tips:When negativity hits, stop to examine the origin.Decide whether changes need to be made.Should changes be in order, decide whether they are minor or major.Begin the process by eliminating the no longer needed.Create a list of what needs to be fixed.Prioritize the list in order of immediate need.Re-energize yourself and/or business by communicating. –shares Image credit: Shutterstock Fireside Chat | July 25: Three Surprising Ways to Build Your Brand Learn from renowned serial entrepreneur David Meltzer how to find your frequency in order to stand out from your competitors and build a brand that is authentic, lasting and impactful. The day that you find you are doubting yourself, take private time to consider why that is. Elinor Stutz Opportunity CEO of Smooth Sale, Author & Inspirational Speakercenter_img September 17, 2016 Next Article Add to Queue 2 min read This story originally appeared on Personal Branding Blog Transform Dark Days into Opportunity Enroll Now for $5last_img read more

first_imgLuokung Technology Corp. (LKCO) (“Luokung” or the “Company”), a leading global spatial-temporal big-data technology company and a leading interactive location-based services company in China, announced that it has signed a stock purchase agreement to acquire 67.36% of Beijing BotBrain AI Technology Ltd and BOTBRAIN AI LIMITED (collectively “BotBrain “).The Company will invest RMB 20 million to BotBrain and will issue 804,162 ordinary shares at USD $7 per share to the former institution investors of BotBrain to obtain 67.36% (the “Acquisition”). The 32.64% share equity of BotBrain will be remained by Mr. Xueyu Lu, the founder and CEO of BotBrain, along with BotBrain ‘s core team members. After the Acquisition, Mr. Lu will continue as CEO of BotBrain AI.BotBrain was established in January 2016, and it has been becoming an advanced provider for intelligent content solutions in China. It’s artificial intelligence algorithms and technology are applied in Chinese semantic analysis, intelligent voice interaction, knowledge graph learning, personalized contents recommendation and other related big data analysis.There are two independent business brands in BotBrain. “Max” content brain is an AI content management and operation platform, which provides AI solutions based on its content services. “BotBrain Zhiyu” is an AI knowledge learning assistant system.Marketing Technology News: Acquia Acquires Mautic to Deliver First-Ever Open Marketing CloudBotBrain has been serving many well-known enterprises based in China, including People’s Daily Overseas, ChinaNews, Kaishu Story, Baby Tree, Baofeng, Bank of China, State Grid, FAW, CreditEase, Facebank and Kingsoft Cloud etc., which involve various industries including media, mobile internet, banking, automobile, financial services, retails and energy.BotBrain has started the cooperation with the Company in technology supports prior the Acquisition, it provides intelligent geographic information algorithms service for us, and Its technology of semantic analysis, knowledge graph and personalized contents recommendation significantly supports the LBS service of Luokung. After the Acquisition, BotBrain will put more investment in the research of intelligent spatial temporal data algorithm and application. BotBrain will provide critical intelligent technologies and application experiences to support our LBS business, personalized full-vector map, and enable us to improve the services we provide to mobile Internet industry and users. Therefore, the Company’s LBS business platform is able to gain a greater competitive advantage.Marketing Technology News: Mareana Named a 2019 Gartner Cool Vendor in Artificial Intelligence Across the Supply ChainThe founder and CEO of BotBrain, Mr. Lu Xueyu processes more than 40 patents relating to the contents intelligence service algorithms. Mr. Lu has more than 13 years experiences in big data and AI industry, he has had an in-depth comprehension and long-term practice in big data, AI and personalized recommendation and Mr. Lu is one of the earliest practitioners in this field in China. Mr. Lu worked in Tencent, Alibaba Youku and Xiaomi and was responsible for the construction and management of big data and artificial intelligence teams, gained many successful implementation experiences for the establishment of big data and recommendation systems. In 2006 in Tencent, Mr. Lu took the lead in using artificial intelligence technology in virus discovery, effectively helped Tencent to protect nearly 1 billion QQ users’ account information security. In Youku, Mr. Lu served as technical director and set up the big data and personalized recommendation system for videos, the system was able to proceed more than 100 billion data daily, it was the system with the highest recommendation accuracy in the field of video websites at that time. During the time in Xiaomi, Mr. Lu was the technical director and was in charge of Xiaomi’s data workshop, he was also responsible for the Xiaomi ecological big data business.Marketing Technology News: RevJet Announces Results of Second Ad Experience Sentiment Report Revealing Change in Sentiment, Behavior of Online Consumers Luokung Technology Corp. Announces to Acquire Artificial Intelligence Company PRNewswireMay 14, 2019, 2:55 pmMay 14, 2019 AcquisitionAIBotBrain AI Technologycontent managementLuokung TechnologyMarketing Technology NewsNews Previous ArticleTechBytes with Adam Solomon, Chief Marketing Officer at LotameNext ArticleGoogle Selects Webpals Mobile to Join App Campaign Partner Programlast_img read more

first_imgUnstoppable Domains, a software company building domains on blockchains, today announced which 60 .zil domains it will auction on June 27. These domains represent the top 60 most watched Zilliqa domain names on the Unstoppable Domains website. The top domain, bitcoin.zil, has already attracted 505 potential buyers.“We are excited to see growing enthusiasm for blockchain domains,” said Matthew Gould, Unstoppable Domains CEO. “These domains provide two very critical benefits to users: they enable people to send crypto to a single human readable name, and they offer a platform to create uncensorable websites. The concepts of free speech and growing the crypto community are really resonating with our customer base.”Marketing Technology News: Triton Digital Integrates Centro’s Basis Platform with the a2x Programmatic Marketplace.Zil domains have seen high demand over the past 3 months, even though top domains have yet to be released. Users can, however, watchlist the domains they are most interested in bidding on during the coming public auction. Here are the top 60 most watchlisted domains:Which domains will be up for auction?1. bitcoin2. crypto3. porn4. blockchain5. money6. insurance7. gold8. cars9. hotels10. satoshi11. bra12. zil13. usa14. bank15. wallet16. beer17. ethereum18. carinsurance19. lasvegas20. pay21. trump22. weed23. travel24. toys25. pizza26. cannabis27. xxx28. litecoin29. privatejet30. music31. xrp32. fb33. z34. shop35. 36036. coffee37. coin38. cash39. vacationrentals40. porno41. hotel42. payme43. booking44. diamond45. insure46. game47. exchange48. 149. ripple50. donaldtrump51. abc52. cardano53. auction54. shoes55. ai56. car57. we58. domain59. elonmusk60. israelThe auction will be split into two phases. During phase I, the 60 most watchlisted domains will be available for a buy now price of $10,000 each. Domains can be purchased using bitcoin, ethereum, litecoin, and bitcoin cash.Marketing Technology News: Mindtree to Showcase Contextual, Real-Time Solutions for Personalized Traveler Experiences at HITEC MinneapolisDuring phase II, domains can only be purchased with Zilliqa.Bidding will start between $10 and $1,000 depending on the price of the domain in the pre-order phase. Each subsequent bid must be at least 5 percent greater than the previous bid. If a person is outbid, they will immediately get their funds returned. New bids will add additional time (~1 hour) to the auction to prevent auction sniping. Also, bidding will be capped at $10,000 per domain. Anyone in the world can participate and anyone in the world can watch the auctions as they happen.Marketing Technology News: CoreMedia Announces CoreMedia Content Cloud – Marketing Connector on Salesforce AppExchange, the World’s Leading Enterprise Cloud Marketplace Marketing TechnologyMatthew GouldNewsUnstoppable DomainsZilliqa Domain Previous ArticleMarTech Interview with Duncan Stockdill, Co-Founder and CEO at CapsuleNext ArticleFranklin Sports Selects CommerceIQ To Empower Their E-Commerce Team To Manage Amazon Holistically Unstoppable Domains Announces the Top 60 Zilliqa Domain Names Up for Auction Business WireJune 19, 2019, 1:45 pmJune 19, 2019 last_img read more

first_imgReviewed by James Ives, M.Psych. (Editor)Mar 20 2019Next-generation sequencing of tumor DNA from patients with colorectal cancer revealed genetic alterations that were linked to different survival and treatment outcomes in an analysis led by a University of North Carolina Lineberger Comprehensive Cancer Center researcher.The findings, published in the Journal of Clinical Oncology, could help define strategies to more effectively treat colorectal cancer, the second leading cause of cancer death in the United States.”This is an example of precision oncology, where using genetics, we are able to stratify tumor types that we once believed were homogeneous, and to identify new patient subgroups that might benefit from tailored therapies,” said UNC Lineberger’s Federico Innocenti, MD, PhD, associate professor in the UNC Eshelman School of Pharmacy Division of Pharmacotherapy and Experimental Therapeutics.For the study, researchers analyzed mutations in tumors of 843 patients who participated in a phase III clinical trial. The trial compared treatment with chemotherapy plus either bevacizumab or cetuximab – regimens which are now the standard of care for this disease in the advanced stage. The researchers used tumor samples to analyze genetic mutations in the DNA. Then, they examined associations between the mutations and data on patients’ responses to the treatments and survival.One key finding from the analysis was that patients who had a lot of genetic repeats in their tumor DNA – known as microsatellite instability – had longer survival when treated with bevacizumab compared to patients treated with cetuximab.”This finding has important potential implications for treatment of patients with microsatellite instability – a subgroup that represented about 7 percent of patients in our study,” Innocenti said.Related StoriesSugary drinks linked to cancer finds studyBacteria in the birth canal linked to lower risk of ovarian cancerStudy reveals link between inflammatory diet and colorectal cancer riskAnother key finding was that patients with tumors that had more genetic variation, which they called high tumor mutational burden, lived longer than patients who had tumors with less variation. The level of tumor mutational burden defines a new subgroup of patients with better prognosis, Innocenti reported.Studies are ongoing in Innocenti’s lab to try to understand the role of the body’s immune system in contributing to the finding. Researchers want to know if these patients with higher tumor mutational burden will be more responsive to treatments that work by unlocking the immune system against cancer.”It is crucial to define which patients could be responsive to immunotherapy in this setting, and this study shows the first promising evidence to do so,” Innocenti said.The study also confirmed findings previously made for patients who had mutations in the BRAF gene in their tumors. They found these patients had worse survival compared to patients who didn’t. Median survival for patients with the mutation was 13.5 months, compared to 30.6 months in patients without mutations.”This mutation was a very strong negative prognostic factor,” Innocenti said. “There was a clear difference in survival.”There was no difference in the study between the different treatment strategies studied in the trial for patients with or without the BRAF mutation. However, Innocenti said the finding confirms these tumors have a different biology and should be treated differently.Additional studies are needed to evaluate and confirm findings with therapeutic implications in patients, Innocenti said. Further research is planned to study additional ways of stratifying patients based on their genetic features to improve outcomes. Source:https://unclineberger.org/news/precision-oncology-insights-revealed-for-colorectal-cancer/last_img read more

first_img Source:https://news.illinois.edu/view/6367/775169 Reviewed by James Ives, M.Psych. (Editor)Apr 17 2019Oxidants found within living organisms are byproducts of metabolism and are essential to wound-healing and immunity. However, when their concentrations become too high, inflammation and tissue damage can occur. University of Illinois engineers have developed and tested a new drug-delivery system that senses high oxidant levels and responds by administering just the right amount of antioxidant to restore this delicate balance.The findings are published in the journal Small.Many pharmaceuticals include specialized polymers and particles that control the timing or concentration of the drug released once administered, the researchers said. However, these additives can hamper crystallization during the manufacturing phase of some drugs – like antioxidants – causing them to dissolve in the body in an uncontrolled manner.”We saw an opportunity here to develop a different kind of drug-delivery system that could sense the level of oxidant in a system and respond by administering antioxidant as needed,” said chemical and biomolecular engineering professor and study co-author Hyunjoon Kong.Kong and his team found a way to assemble crystals of catechin – the bright green antioxidant found in green tea – using a polymer that can sense when oxidant concentrations become too high. The researchers tested the responsiveness of the resulting catechin crystal-containing polymer in the common freshwater planktonic crustacean Daphnia magna, the water flea.”Heart rate is an indication of the extent to which potentially toxic chemicals influence physiology in water fleas,” Kong said. “Daphnids are often used to monitor environmental impacts on ecological systems, and because their hearts are similar to those of vertebrates, they are also used to evaluate the efficacy of cardioprotective drugs.”Related StoriesChronic inflammation removes motivation by reducing dopamine in the brainCancer incidence among children and young adults with congenital heart diseaseStudy measures antioxidant levels in edible insectsThe researchers exposed the daphnids to water contaminated with sublethal concentrations of the natural oxidant hydrogen peroxide while monitoring their heart rate. They found that the daphnids’ mean heart rates dropped from 348 to 290 and 277 beats per minute, depending on the concentration of hydrogen peroxide used.When the team added the new catechin crystal assembled with polymer to the experiment, the water fleas eventually recovered a close-to-normal heart rate.Beyond the potential pharmaceutical uses for the new polymer, Kong’s group is looking into its use for curtailing the impact of highly oxidizing chemicals in natural waterways.”Hydrogen peroxide is often used to clean water fouled by excessive algae, and this raises concern about how the oxidant may be affecting living organisms in water,” he said. “We think this new antioxidant-delivery system could be used to address the problem of over-oxidized natural waters.”The researchers plan to push ahead with developing the polymer for pharmaceutical and environmental uses. “This study proved a concept, but we have more work to do,” Kong said. “There is concern over the safety of the specific polymer we used – polyethylenimine diselenide – but we are getting close to finding a viable replacement.”last_img read more

first_img Explore further France is ready to consider cutting its stake in Renault in the interests of consolidating the automaker’s alliance with Nissan, Finance Minister Bruno Le Maire said Saturday. © 2019 AFP This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Renault tries to reassure partner Nissan on Fiat planscenter_img Citation: France ready to cut Renault stake to shore up Nissan partnership: minister (2019, June 8) retrieved 17 July 2019 from https://phys.org/news/2019-06-france-ready-renault-staketo-shore.html Le Maire said Renault should concentrate on forging closer ties with Nissan before seeking other alliances He was speaking in Japan after Italian-US carmaker Fiat Chrysler pulled the plug on its proposed merger with Renault, saying negotiations had become “unreasonable” due to political resistance in Paris.In an interview with AFP on the sidelines of the G20 finance ministers meeting in Japan, Le Maire said Paris might consider reducing the state’s 15-percent stake in Renault if it led to a “more solid” alliance between the Japanese and French firms.”We can reduce the state’s stake in Renault’s capital. This is not a problem as long as, at the end of the process, we have a more solid auto sector and a more solid alliance between the two great car manufacturers Nissan and Renault,” he told AFP.Last week, FCA stunned the auto world with a proposed “merger of equals” with Renault that would—together with Renault’s Japanese partners Nissan and Mitsubishi Motors—create a car giant spanning the globe. The combined group would have been by far the world’s biggest, with total sales of some 15 million vehicles, compared to both Volkswagen and Toyota, which sell around 10.6 million apiece.But the deal collapsed suddenly on Thursday, with FCA laying the blame at the door of Paris. “It has become clear that the political conditions in France do not currently exist for such a combination to proceed successfully,” FCA said in a statement.Le Maire said Renault should concentrate on forging closer ties with its Japanese partner Nissan before seeking other alliances.Things need to be done “in the right order…. First the alliance (between Nissan and Renault) should be consolidated and then consolidation (more generally) and not one before the other.””Otherwise, everything risks collapsing like a house of cards,” he warned.The minister said it would be up to the bosses of Renault and Nissan to decide how to push the alliance forward as ties between the two firms have been strained after the shock arrest of former boss Carlos Ghosn.Renault is pushing for a full merger between the pair but there is deep scepticism of the plan at Nissan.There were varied reactions from the French unions Saturday.”The government is behaving like the agent of the big shareholders, favouring short-term profit to the detriment of the interests of the country,” said Fabien Gache, of the CGT union.Cutting the state’s share in Renault was abandoning its responsibility in the country’s auto industry, he argued.Franck Daout of the CFDT union said it backed a three-way alliance between Renault, Nissan and Japan’s Mitsubishi—but not one between Nissan and Renault until the alliance had reached a “safe and sustainable maturity”.last_img read more