About the authorFreddie TaylorShare the loveHave your say Liverpool hero Aldridge: Klopp must cull two or three playersby Freddie Taylor10 months agoSend to a friendShare the loveLiverpool hero John Aldridge has advised Jurgen Klopp to replace two or three players this summer.The Reds boss fielded his second string XI in Monday night’s FA Cup loss to Wolves.Without naming names, Aldridge believes a few of those fringe senior players blew their chance.”The goals we conceded against Wolves were really poor,” Aldridge wrote in his Liverpool Echo column.”James Milner has been almost faultless this season but he made a bad mistake and got punished with their opening goal.”Then after we got ourselves back into the game at 1-1 we were so slow to close Ruben Neves down and he hammered one into the bottom corner. It was a great hit but he shouldn’t have been allowed to get the shot away.”Two or three of that line up won’t be at the club come the start of pre-season.”I don’t want to name names but we all know who they are. Monday night underlined that they need to be replaced.”Klopp gave an opportunity to some senior pros who have been waiting for their chance but they wasted it.”I didn’t see players showing they were willing to run through a brick wall for the club. They played within themselves and that’s not good enough.”Hoever and fellow youngsters Curtis Jones and Rafa Camacho needed help but they got very little.”You certainly couldn’t attach any blame to the young lads. They tried their hardest but they were let down by senior players who didn’t give their all.”
Brighton boss Potter delivers challenge to Bissoumaby Paul Vegasa month agoSend to a friendShare the loveGraham Potter is hoping Yves Bissouma can add goals to his Brighton side against Aston Villa on Wednesday.Bissouma came off the bench against Newcastle last Saturday and will likely start in the Carabao Cup clash with Villa.Quizzed on whether Bissouma can add to his side’s goalscoring threat, Potter said: “I think so. He has got the qualities.”It is about getting him into the right areas of the pitch, getting him to shoot at the right time and from the right places – because sometimes he shoots from maybe not the best location – but you can see his ability.”He has only been training with us a week but you can already tell he’s that type of footballer, a free player, that can excite and get a crowd off their seats.”He has worked hard to get back from his injury and we’re looking forward to seeing him on the pitch on Wednesday.”It is a good game for him to get some time on the pitch.” About the authorPaul VegasShare the loveHave your say
About the authorPaul VegasShare the loveHave your say Southampton boss Hasenhuttl delighted with Ings formby Paul Vegas8 days agoSend to a friendShare the loveSouthampton manager Ralph Hasenhuttl is delighted with the form of Danny Ings.Ings has scored four goals in his last three matches in all competitions and Hasenhuttl has been speaking about his form. He stated, “Danny is in really good shape at the moment. He had a really god pre-season, without injuries, and this is the most important thing for him. “That is why he can work so hard at the moment, he has a great workload for the team. “When he has the ball, he has the quality to score, he gets a lot of chances at the moment, which helps us absolutely. “What I like about Danny is he is also open-minded, he is a very positive character for this team and I hope he will continue his run.”
Kolkata: The health condition of former chief minister Buddhadeb Bhattacharjee has improved on Sunday, with his chest X-ray showing signs of stability. It also showed the improvement of pneumonitis which Bhattacharjee had been suffering from. The press statement issued by the hospital on Sunday said that his hemoglobin level has risen to 10 gm/dl and the carbon dioxide levels have come down, giving a sense of relief to the doctors.A medical board of eight doctors was formed for the treatment of the former chief minister on Sunday morning. The press statement also stated that Bhattacharjee has been maintaining stability in all the vital parameters. He also took food, ice cream and tea orally on Sunday morning. BiPAP (non-invasive ventilation) was conducted on the patient for nearly six hours on Saturday night and the oxygen level has now increased in his body. He was fully conscious on Sunday and talked to the doctors and his family members. However, he will continue to need oxygen. Bhattacharjee, a chronic obstructive pulmonary disease (COPD) patient, was admitted to a private hospital in the city with multiple cardiac ailments on Friday.
Mir Afsar Ali has come up with an album ‘Awshomapto’ – a monologue by the poet/author, where he recollects his memories of different endeavours – all of which has a common ground of love.His memoirs of six different phases of life which he had gone through in his lifetime are recorded. The album was released on April 12 in Kolkata. In all the phases, he thinks his main strength – escape refuge – and in the end the place where it all kind of converges in one point is songs and verses by Rabindranath Tagore. Also Read – An income drop can harm brainHere we are connecting these six dots with six expressive Tagore songs in the project. List of songs (In exact order) Bhalobashi Bhalobashi (Koishorer Bhalobasha) Diosho Rojoni Ami Jeno Kar Ashae Ashae Thaki E Parobashe Iboshdo – Biroho (The distance in a relationship) Dekho Sokha Bhul Kore Bhalobeshona – (The labour of love) Chaya Ghonayeche Bonay Bonay(death separates) Megh Boleche Jabo The album stars following people: Male lead – Mir Afsar Ali (story teller) Also Read – Shallu Jindal honoured with Mahatma AwardFemale lead – Jayati Chakraborty (song) Composition and lyrics – Rabindra Nath Tagore Concept and music direction – Ashu Chakraborty Script – Rajib Chakraborty Hindusthan Records, the forerunner to The Indian Record Manufacturing Company Ltd (INRECO), began its journey in the early decades of 1900s. Being the oldest Indian music label in the country, it was evidently popular as the only Indian Music Company. Rabindranath Tagore recorded his first recording with ‘Hindusthan Records’ and encouraged his disciples to record as well. The music label has the top recording artists of the past hundred years including K L Saigal, S D Burman, Debabrata Biswas, Subinoy Roy, Pankaj Kumar Mullick, Amar Pal, Kanika Banerjee,Pannalal Bhattacharjee, Mohiner Ghoraguli, Abbasuddin, Gyan Prakash Ghosh, Kazi Nazrul Islam, Kanan Devi, Feroza Begum, Begum Akhtar, Mehdi Hassan, Ghulam Ali and other luminaries. As the format changed, the need of the hour was to take a strategic decision to diversify into the domain of emerging media and technology. INRECO was the first to get into the Digital Domain.
New Delhi: Andhra Pradesh Chief Minister N Chandrababu Naidu Wednesday met Congress President Rahul Gandhi and discussed plans to hold a meeting of Opposition parties on May 21, two days ahead of Lok Sabha results to chalk out a post-poll alliance. Naidu met Gandhi before heading out to West Bengal to attend public rallies in support of the ruling Trinamool Congress in the state, sources said. In a brief meeting, the Telugu Desam Party (TDP) chief is believed to have discussed the voter-verified paper audit trail (VVPAT) issue, voting percentage in the recently held five phase polling besides the Andhra Assembly election developments, the sources said. Also Read – India gets first tranche of Swiss account details under automatic exchange framework The sources said Naidu and Gandhi also discussed the post-poll scenario and more or less agreed to call a meeting of Opposition parties on May 21. The Lok Sabha elections are being held in seven phases. So far, polling in five phases are over and the counting of votes will be on May 23. Naidu will be meeting West Bengal Chief Minister and Trinamool Congress chief Mamata Banerjee apart from attending her rallies on Wednesday and Thursday. The Andhra Pradesh CM was in Delhi to attend the Supreme Court hearing on a petition filed by the Opposition parties to review its judgment rejecting 50 per cent random physical verification of EVMs using VVPATs. The apex court dismissed the petition following which the parties again met the Election Commission to press their demand.
The Lega Serie A yesterday voted unanimously to dismiss the contract with Spanish broadcaster Mediapro after it said the latter had failed to provide necessary guarantees, so the Serie A TV rights will return on the market.The Spanish broker had previously won the bidding war for the rights in February for €1.05bn, but Sky Sport Italia sued and won a court case to have the tender suspended for not respecting Italian antitrust regulations, hence the deal termination.Sky claimed that Spanish broadcaster, Mediapro bid was in a process reserved for independent intermediaries, but that it was a broadcaster rather than an intermediary, and had no capacity to distribute the competition in the Italian market.Quiz: How much do you know about David Villa? Boro Tanchev – September 14, 2019 Time to test your knowledge about Spanish legendary forward David Villa.Even though Mediapro had offered to provide more financial guarantees, the Lega Serie A saw all 20 clubs vote unanimously to terminate the contract.Mediapro now has seven days to commit to a €1.2 billion guarantee to avoid the contract being cancelled definitively, according to Spanish financial daily El Español,That decision will be valid a week today, so Sky and Mediaset are now back in the race to snap up the rights for the 2018-21 seasons.
Paris Saint-Germain boss Thomas Tuchel has revealed that they are close to completing deadline-day deals for Eric Maxim Choupo-Moting and Juan BernatBernat only made 12 appearances at Bayern Munich last season and will likely provide cover for fellow new left-back Yuri Berchiche, who joined from Athletic Bilbao earlier this summer.Although the signing that has intrigued people the most is Cameroon attacker Choupo-Moting, who could only manage five goals in 30 Premier League games for the relegated Stoke City.“It’s August 31, it’s very late, I’m not going to lie,” said Tuchel, according to FourFourTwo.“We’re trying to get the two players signed, they’re doing their medical tests now. I do not know if others will follow.“We’ve been looking for a few weeks for cover for [Edinson] Cavani, the opportunity has come with Maxim, who is a top-level player, who can impact right away when he comes off the bench.“With the arrival of Choupo-Moting, it’s a lot of attackers. It can impact [Timothy] Weah’s situation, but at the same time not, because it’s another type of player.”Goalkeeper Kevin Trapp has been linked with a permanent move to Eintracht Frankfurt, while Giovani Lo Celso is expected to complete a transfer to La Liga side Real Betis.“Trapp wants to leave, he’s trying to sign with another club,” Tuchel confirmed.“Lo Celso, I do not know exactly what he’s up to.”Midfielder Marco Verratti is a doubt for Saturday’s trip to promoted Nimes as PSG look to maintain their winning start to the new season.PSG ultras sent a warning letter to Neymar Manuel R. Medina – September 14, 2019 Brazilian superstar Neymar might play today his first game of the season for Paris Saint-Germain and the team’s ultras have warned him.“Verratti has resumed training,” Tuchel added.“We will decide together after the session of the day if he is with us in Nimes.”The Ligue 1 champions have been pitted against Red Star Belgrade, Napoli and Liverpool in Group C of this season’s Champions League.Although Tuchel is looking forward to going head-to-head with new Napoli boss Carlo Ancelotti.“Ancelotti is a great coach,” he said.“He was a great inspiration to me.”? Mark your calendars! ??1⃣ 18/09 21h CET ??????? @LFC v PSG2⃣ 03/10 18h55 CET ?PSG v @crvenazvezdafk3⃣ 24/10 21h CET ?PSG v @en_sscnapoli4⃣ 06/11 21h CET ?? @en_sscnapoli v PSG5⃣ 28/11 21h CET ?PSG v @LFC6⃣ 11/12 21h CET ?? @crvenazvezdafk v PSG pic.twitter.com/hCExSmWcHp— Paris Saint-Germain (@PSG_English) August 31, 2018
Justin Kluivert is eyeing more playing opportunities at AS Roma after registering his first goal for the clubDespite making just two starts and three substitute appearances for Roma this season, Kluivert has made a positive start to life in Italy and found the net for his new club in their 5-0 win over Viktoria Plzen in the Champions League.Now the 19-year-old winger intends to build on scoring his first goal by continuing to give coach Eusebio Di Francesco more reasons to select him.“I’d like to play more games from the first minute and I hope it happens more often in the future,” Kluivert told Fox Sports.“For now, I can’t complain, I feel like I’m growing so much and I feel good at Roma.“I’m trying to come through, but I have great confidence in myself and I’m ready to show my worth.Karsdorp reveals he had too much stress at Roma Manuel R. Medina – September 14, 2019 The Dutch defender has been with the Gialorrossi since 2017, but he has not enjoyed his time in the Italian Lega Serie A.“I know it’s easy to go from being a great talent to a player who risks not making it, but for me, it’s not a problem whatsoever. I have to keep proving myself.“However, I know that sooner or later my time will come. I just have to keep training hard, like I’m already doing.”Kluivert had been linked with moves to Barcelona and Manchester United in the summer before making a surprise switch to Roma.💛❤️🐺 #ForzaRoma pic.twitter.com/NruKWgLt74— Justin Kluivert (@justin_kluivert) October 3, 2018
Dan Cohen AUTHOR Senate Majority Leader Mitch McConnell (R-Ky.) filed cloture Thursday on the conference report for the fiscal 2016 defense authorization bill, setting up a procedural vote to limit debate most likely on Tuesday.Earlier on Thursday, the House adopted the conference report for the legislation, H.R. 1735, but not with enough votes to override a threatened veto of the bill by President Obama. House members voted 270-156 to advance the conference report, with Democratic opposition sufficient enough to sustain a veto. The House would need a two-thirds majority — at least 290 votes — to override the promised veto from the president.While the Obama administration opposes numerous provisions in the compromise legislation — including its failure to approve a BRAC round in 2017 and restrictions on closing the prison at Guantánamo Bay — the most significant objection stems from the measure’s reliance on DOD’s overseas contingency operations (OCO) account to sidestep the Budget Control Act spending caps.The bill would authorize $612 billion in national security spending, the same amount the White House requested. The measure leaves the discretionary budget caps in place, and authorizes only $496 billion for DOD’s base budget. To make up the shortfall, it shifts $38 billion in operation and maintenance funds from the base budget to DOD’s OCO account, which is not subject to the caps. The bill would authorize a total of $89 billion for that account.The White House has demanded that Congress lift the caps on both defense and non-defense spending, and return the $38 billion to DOD’s base budget.Much of the debate prior to the House vote focused on the veto threat, which Republicans criticized given that the total amount of spending authorized under the bill equals the administration’s budget request, reported CQ.“Frankly whether you call it base funding, OCO funding or pumpernickel it doesn’t matter. It is money that goes to the troops,” said House Armed Services Chair Mac Thornberry (R-Texas), who accused the White House of “playing politics.”The committee’s ranking Democrat, Adam Smith (Wash.), acknowledged the legislation was “by and large a good bill,” but said the GOP budget framework evaded the larger issue of the discretionary spending caps.“Is this good for our country? Is it good for our troops?” Smith said. “I don’t believe that it is.”
WILMINGTON, MA — Below are job listings previously published on Wilmington Apple during the week of February 3, 2019:Full-Time Warehouse Person (Loader) at Pepsi Co.Part-Time Merchandiser at Pepsi Co.Full-Time Customer Service Manager at Serur AgenciesFull-Time Shipper/Receiver at AJ Mailing CompanyFull-Time Customer Service Representative at Parts4HeatingFull-Time Customer Service Rep at SpeedwayFull-Time Claims Representative at AmetrosFull-Time Customer Support at AltroPart-Time Worker at Garrick-Santo Landscaping Co.Full-Time Team Leaders at TargetPart-Time Crew Member at McDonald’sPart-Time Summer Coaches & Directors at Skyhawks Sports AcademyFull-Time Receptionist at Stuffed FoodsFull-Time Office Manager at Super Service TodayFull-Time Maintenance Technician at Stafford Manufacturing Corp.Full-Time Data Presort & Laser Printing at AJ Mailing CompanyFull-Time Warehouse Loader at Pepsi Co.Full-Time Manufacturing Technician at AmetekFull-Time Construction Project Manager at Channel BuildingFull-Time HR Business Partner at Charles River LabsFull-Time Service Technician at Cochrane VentilationFull-Time Sample Program Manager at Analog DevicesFull-Time RF Test Technician at Analog DevicesFull-Time Driver/Courier at Kirkwood PrintingFull-Time Operations Manager at Patterson CompaniesPart-Time Assistant Preschool Teacher at Abundant Life Christian Learning CenterPart-Time Residential Life Coach at NuPathFull-Time Account Executive at ComcastFull-Time Club Manager at Planet FitnessFull-Time Assistant Manager at Planet FitnessFull-Time Counter Sales Associate at Lennox InternationalFull-Time Solar Site Surveyor at Vivint SolarPart-Time Engineering Intern at Analog DevicesPart-Time Marketing Events Intern (Summer) at Charles River LabsFull-Time Sanitation Worker at Stuffed FoodsFull-Time Warehouse Associate at NAPA Auto PartsFull-Time Movers & Drivers at Two Men And A TruckFull-Time QA Manager at SpectraPart-Time Security Officer at Allied UniversalFull-Time Manufacturing Technician at Kelly ServicesFull-Time Customer Service Representative at Heilind ElectronicsFull-Time EMC Lab Technician at Analog DevicesFull-Time Technician I at Charles River LabsFull-Time Medical Network Manager at AmetrosFull-Time Sales Office Manager at Harrington Industrial PlasticsFull-Time Warehouse Lead/Back Up Driver at Harrington Industrial PlasticsFull-Time ABA Classroom Counselor at May InstituteFull-Time Clinical Supervisor at May InstitutePart-Time Package Handler at FedEx WarehouseFull-Time & Part-Time Servers at 99 Restaurant(NOTE: Wilmington businesses — Feel free to send me your job postings at firstname.lastname@example.org.)Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email email@example.com.Share this:TwitterFacebookLike this:Like Loading… RelatedNOW HIRING: 50 New Job Openings In Wilmington (Week of August 18, 2019)In “Business”NOW HIRING: 50 New Job Openings In Wilmington (Week of June 23, 2019)In “Business”NOW HIRING: 60 New Job Openings In Wilmington (Week of June 30, 2019)In “Business”
See It Read Google Home Hub review Galaxy’s Edge from every angle: We take you along for… Rylo 5.8K 360 Video Camera: $250 (save $250) $59 at eBay Mentioned Above Apple iPhone XS (64GB, space gray) Post a comment Other Labor Day sales you should check out Best Buy: In addition to some pretty solid MacBook deals that have been running for about a week already, Best Buy is offering up to 40% off major appliances like washers, dryers and stoves. There are also gift cards available with the purchase of select appliances. See it at Best BuyDell: Through Aug. 28, Dell is offering an extra 12% off various laptops, desktops and electronics. And check back starting Aug. 29 for a big batch of Labor Day doorbusters. See it at DellGlassesUSA: Aug. 29 – Sept. 3 only, you can save 65% on all frames with promo code labor65. See it at GlassesUSALenovo: The tech company is offering a large assortment of deals and doorbusters through Labor Day, with the promise of up to 56% off certain items — including, at this writing, the IdeaPad 730S laptop for $700 (save $300).See it at LenovoLensabl: Want to keep the frames you already love and paid for? Lensabl lets you mail them in for new lenses, based on your prescription. From now through Sept. 2 only, you can save 20% on the blue light-blocking lens option with promo code BLOCKBLUE. See it at LensablSears: Between now and Sept. 7, you can save up to 40% on appliances (plus an additional 10% if you shop online), up to 60% on mattresses, up to 50% on Craftsman products and more. The store is also offering some fairly hefty cashback bonuses. See it at SearsNote: This post was published previously and is continuously updated with new information.CNET’s Cheapskate scours the web for great deals on tech products and much more. For the latest deals and updates, follow the Cheapskate on Facebook and Twitter. Questions about the Cheapskate blog? Find the answers on our FAQ page, and find more great buys on the CNET Deals page. Amazon Best laptops for college students: We’ve got an affordable laptop for every student. Best live TV streaming services: Ditch your cable company but keep the live channels and DVR. Rylo $520 at HP Tidal 3-month family subscription: $5.99 (save $54) 0 The Cheapskate $999 Sarah Tew/CNET $999 Share your voice Spotify and most other streaming services rely on compressed audio, which robs the listener of full fidelity. Enter Tidal, the only “major” service that delivers lossless audio — meaning at least on par with CD quality, if not better. Want to see (er, hear) the difference for yourself? Grab this excellent extended trial while you can. It’s just $6 for three months, and it’s good for up to six listeners. $155 at Google Express I thought this might be a mistake, but, no, the weirdly named HP Laptop 15t Value is indeed quite the value at this price. Specs include an Intel Core i7 processor, 12GB of RAM, a 256GB solid-state drive and a 15.6-inch display. However, I strongly recommend paying an extra $50 to upgrade that display to FHD (1,920×1,080), because you’re not likely to be happy with the native 1,366×768 resolution. Studio Ghibli’s Totoro and The Catbus at MCM London Comic Con. Ollie Millington/WireImage/Getty A Studio Ghibli theme park is being built in Japan, reports say.The park, based on the Tokyo anime studio’s films, will be in Expo 2005 Aichi Commemorative Park near Nagoya, according to Variety, and will open in fall 2022.It’s expected to have five themed areas, including Princess Mononoke and Howl’s Moving Castle. My Neighbor Totoro will also be featured in the park, IGN reported. Academy Award-winning film Spirited Away was not mentioned in either report.During a press conference Friday, Studio Ghibli producer Toshio Suzuki reportedly said film creator Hayao Miyazaki is working on the park’s creative side.”[Miyazaki] can’t leave anything up to other people. He’s a meddlesome old man,” Variety reported Suzuki as saying. “[He] is not the type to look on supportively from a distance. He starts in right away with ‘do this’ and ‘don’t do that.'” $261 at Daily Steals via Google Express Read DJI Osmo Action preview The problem with most entry-level laptops: They come with mechanical hard drives. That makes for a mighty slow Windows experience. This Lenovo model features a 128GB solid-state drive, so it should be pretty quick to boot and load software, even with its basic processor. Plus, it has a DVD-burner! That’s not something you see in many modern laptops, especially at this price. Read Lenovo Smart Clock review Culture TV and Movies,I’m shocked — shocked! — to learn that stores are turning Labor Day into an excuse to sell stuff. Wait — no, I’m not. As much as I respect the original intent of the holiday (which became official back in 1894), to most of us, it’s just a bonus day off — one that’s blissfully tacked onto a weekend. So, yeah, stores; go ahead, run your sales. I’m listening. Perhaps unsurprisingly, Labor Day doesn’t bring out bargains to compete with the likes of Black Friday (which will be here before you know it), but there are definitely some sales worth your time.For example:We’ve rounded up the best Labor Day mattress deals.We’ve also gathered the best Labor Day laptop deals at Best Buy.The 2019 Vizio P Series Quantum is back under $999.Be sure to check out Amazon’s roughly three dozen Labor Day deals on TVs and audio. Google Express is having a big sale as well, one that includes deals on game consoles, AirPods, iPhones, laptops and more.Below I’ve rounded up a handful of individual items I consider to be the cream of the crop, followed by a handy reference guide to other Labor Day sales. Keep in mind, of course, that products may sell out at any time, even if the sale itself is still running. Note that CNET may get a share of revenue from the sale of the products featured on this page. Sprint $999 Angela Lang/CNET Formerly known as the Google Home Hub, Google’s Nest Hub packs a wealth of Google Assistant goodness into a 7-inch screen. At $59, this is within a buck of the best price we’ve seen. It lists for $129 and sells elsewhere in the $89-to-$99 range.This is one item of many available as part of eBay’s Labor Day Sale (which, at this writing, doesn’t specifically mention Labor Day, but that’s how it was pitched to us). See at Turo Preview • iPhone XS is the new $1,000 iPhone X Best Buy Sarah Tew/CNET Comments Now playing: Watch this: What’s cooler: A snapshot of a firework exploding in front of you, or full 360-degree video of all the fireworks and all the reactions to seeing them? Oooh, ahhh, indeed. At $250, the compact Rylo dual-lens camera is selling for its lowest price yet. And for an extra $50, you can get the bundle that includes the waterproof housing.This deal runs through Sept. 3; it usually costs $500. 15:04 Turo: Save $30 on any car rental Share your voice Free Echo Dot with an Insignia or Toshiba TV (save $50) See It Lenovo Smart Clock: $59.99 (save $20) Lenovo 130-15AST 15.6-inch laptop: $210 (save $90) Apple iPhone XS Tags $90 at Daily Steals via Google Express Tags Chris Monroe/CNET An Echo Dot makes a fine match for any Fire edition TV, because you can use the latter to say things like, “Alexa, turn on the TV.” Right now, the 24-inch Insignia Fire TV Edition starts at just $100, while the 32-inch Toshiba Fire TV Editions is on sale for $130. Just add any Fire TV Edition to your cart, then add a third-gen Echo Dot, and presto: The latter is free. Turo Turo is kind of like Uber meets Airbnb: You borrow someone’s car, but you do all the driving. I’ve used it many times and found it a great alternative to traditional car-rental services — in part because you get to choose exactly the vehicle you want (not just, say, “midsize”) and in part because you can often do pickup and dropoff right outside baggage claim.Between now and Sept. 1, the first 300 people to check out can get $30 off any Turo rental with promo code LDW30. Read the AirPods review DJI’s answer to GoPro’s action cameras is rugged little model that’s shockproof, dustproof and waterproof down to 11 meters. It normally runs $350, but this deal drops it to $261 when you apply promo code 19LABOR10 at checkout. $299 at Amazon $999 Google Nest Hub: $59 (save $70) See it JBL Soundgear wearable speaker: $90 (save $160) Use promo code 19LABOR10 to get an unusually good deal on JBL’s interesting hybrid product — not quite headphones, and not quite a traditional speaker, but something you wear like neckphones to listen to music on the go. See at Amazon 7 See It $210 at Best Buy Review • iPhone XS review, updated: A few luxury upgrades over the XR DJI Osmo Action camera: $261 (save $89) TVs Speakers Mobile Accessories Cameras Laptops Automobiles Smart Speakers & Displays Sarah Tew/CNET Sarah Tew/CNET Boost Mobile $60 at Best Buy Apple AirPods with Wireless Charging Case: $155 (save $45) CNET may get a commission from retail offers. Though not technically a Labor Day sale, it’s happening during Labor Day sale season — and it’s too good not to share. Nationwide Distributors, via Google Express, has just about the best AirPods deal we’ve seen (when you apply promo code ZBEDWZ at checkout). This is for the second-gen AirPods with the wireless charging case. Can’t imagine these will last long at this price, so if you’re interested, act fast. Read the Rylo camera preview $6 at Tidal HP Laptop 15t Value: $520 (save $780) Recently updated to include digital-photo-frame capabilities, the Lenovo Smart Clock brings Google Assistant goodness to your nightstand. It’s a little smaller than the Amazon Echo Show 5, but also a full $30 less (and tied with Prime Day pricing) during this Best Buy Labor Day sale.
Major Rohingya refugee camp populations in Bangladesh. AFPA plan to start repatriating Rohingya Muslims back to Myanmar is premature and the refugees are “terrified” about leaving Bangladesh where they sought refuge, dozens of aid agencies working in the region said Friday.More than 720,000 Rohingya Muslims fled Myanmar’s northern Rakhine state after a heavyhanded army crackdown in August last year that survivors say involved mass rape and extrajudicial killings.UN officials say the country’s military leaders should be investigated for genocide but Myanmar has rebuffed the calls, arguing it was only defending itself against Rohingya militants who attacked police posts.Both Bangladesh and Myanmar signed a repatriation agreement in November last year to allow Rohingya to return but many fear going back without guarantees of citizenship, freedom of movement and safety.However the governments confirmed in recent weeks that they were pushing ahead with the first large-scale repatriation set for mid-November, prompting an outcry from activists who say conditions on the ground in Rakhine are not adequate to take the refugees back.Rohingya Camp”They are terrified about what will happen to them if they are returned to Myanmar now, and distressed by the lack of information they have received,” the group of 42 aid agencies and civil society groups said in a statement that referred to the push as “dangerous.””They fled to Bangladesh to seek safety and they are very grateful to the Government of Bangladesh for giving them a safe haven.”Oxfam, World Vision and Save the Children were among the groups working in Myanmar and Bangladesh that signed the statement.They said refugees fear living in enclosed settlements like the one in central Rakhine state, where more than 120,000 Rohingya have been confined to camps for six years since intercommunal violence erupted in the region in 2012.Myint Khaing, the Maungdaw township administrator in northern Rakhine, told AFP that November 15 is the estimated repatriation start date and that the plan is to receive more than 2,200 people in total at a rate of 150 per day.But he seemed unsure if it would go ahead.”We can confirm only on the 15th whether the people from our given list are coming or not,” he said.Northern Rakhine has been largely sealed off since the crackdown except for tightly organised government trips for media and senior visiting diplomats.The UN has been granted access to the area to assess conditions on the ground but the approvals have been slow and the amount of territory accessible has been limited.Authorities in Bangladesh worry that Rohingya may once again risk travelling to other parts of Southeast Asia by boat, a route previously popular with those seeking economic opportunities outside the grim camps.This week Bangladesh’s coast guard rescued 33 Rohingyas and detained six alleged human traffickers from a fishing trawler headed for Malaysia in the Bay of Bengal.
Location of Burkina Faso. Photo: Google MapAt least nine civilians have been killed in twin attacks in eastern Burkina Faso, a poor West African country where jihadists have been gaining ground in recent months, local authorities said Saturday.“Two terror attacks were carried out in the villages of Diabiga and Kompienbiga” overnight Friday in eastern Kompienga province, the regional governor said in an earlier statement.An unnamed security source told AFP that one of the attacks had targeted the home of a Islamic religious leader and other Muslims.“Five people including the leader were killed,” he said, adding that three others were injured on the attack on the house which is next to a mosque.One of the injured later succumbed to their wounds.Meanwhile, “three people belonging to the same family were killed and another two injured by suspected jihadists on mopeds,” according to another security source.Since 2015, Burkina Faso has battled increased Islamist violence of the sort that plagues neighbouring Mali and Niger, and experts say the recent surge is likely the result of pressure on jihadist insurgents there.The capital Ouagadougou has been hit by three attacks over the past two years leaving a total of 60 people dead.Last week Burkinabe president Roch Marc Christian Kabore promised new security measures “to eradicate the scourge of terrorism”.
US Senator Kirsten Gillibrand (D-NY) speaks outside the US Supreme Court during a vigil in opposition to US Supreme Court nominee Brett Kavanaugh in Washington, US on 3 October 2016. Photo: ReutersThe FBI’s report on sexual misconduct allegations against US Supreme Court nominee Brett Kavanaugh neared completion late on Wednesday as the battle over his selection by president Donald Trump approached a new turning point.The Senate was expected to receive the report by early on Thursday two sources familiar with the matter said. Senators were to be granted access to review it during the day on Thursday.While the report’s conclusions were as yet unknown, there was already a partisan battle over it as Trump and the Senate Republican leadership battled to corral enough support for a majority vote for Kavanaugh in the days ahead.Democrats were in near unanimity against Kavanaugh, a conservative federal appeals court judge.US Senate Majority Leader Mitch McConnell set up a procedural vote for as early as Friday on the Kavanaugh nomination.McConnell, a Republican, filed a petition for a so-called cloture vote, which if successful would limit debate on the Kavanaugh nomination and start the clock ticking on a final 30-hour waiting period before the Senate could vote to confirm the nominee.After filing a cloture petition, lawmakers must wait one legislative day before proceeding to the cloture vote, according to Senate rules. That means a cloture vote could come on Friday morning at the soonest.“It’s time to put this sickening display behind us,” McConnell said in remarks on the Senate floor earlier in the day. “The Senate will vote on this nomination this week.”Several people with information related to allegations against Kavanaugh told Reuters they had not heard from the FBI, suggesting its report may be narrower than was desired by some of the lawmakers who demanded it just days ago.Christine Blasey Ford, a college professor from California who accused Kavanaugh of assaulting her in 1982 when they were high school students, has not been contacted by the FBI, her attorneys said.As Senate Republican leaders marched toward a final vote on Kavanaugh’s nomination, perhaps over the weekend, the three Republicans who could be key to whether Kavanaugh is confirmed – Senators Jeff Flake, Susan Collins and Lisa Murkowski -criticized Trump for his remarks about Ford at a political rally in Mississippi on Tuesday.Ford, who testified last week at an extraordinary Senate Judiciary Committee hearing, said she could not remember the precise date or location of the alleged assault or how she got home later, but offered a detailed account of the incident.She said a drunken Kavanaugh pinned her down, tried to remove her clothing and covered her mouth when she screamed.Imitating Ford’s testimony, Trump, who was himself accused during the 2016 presidential race of sexual misconduct with numerous women, said: “What neighborhood was it in? I don’t know. Where’s the house? I don’t know. Upstairs, downstairs, where was it? I don’t know. But I had one beer. That’s the only thing I remember.”“And a man’s life is in tatters,” Trump added.Flake told NBC’s “Today” show that “there’s no time and no place for remarks like that, that discuss something this sensitive at a political rally … It’s kind of appalling.”Collins told reporters: “The president’s comments were just plain wrong.” She did not respond when asked if his comments would affect her vote on Kavanaugh’s confirmation.Asked whether Trump’s comments would affect her vote, Murkowski told reporters: “I am taking everything into account. The president’s comments yesterday mocking Dr. Ford were wholly inappropriate and, in my view, unacceptable.”A day after the hearing, Trump had called Ford “a very credible witness” who provided “very compelling” testimony.Kavanaugh has denied Ford’s accusation as well as allegations by two other women, all dating from the 1980s, while accusing Democrats of a political “hit.”‘Clearly a reason’Flake was instrumental last Friday in getting Trump to order an FBI investigation into the allegations against Kavanaugh, nominated by Trump for a lifetime job on the top US court.Trump limited the investigation to no more than a week.Senator Dick Durbin, the No. 2 Senate Democrat, complained in an interview with Reuters that the White House had not responded to requests for documents detailing its instructions to the FBI about the scope of its investigation of Kavanaugh.“There’s clearly a reason for that and I assume the administration doesn’t want members of Congress and the public to see it,” Durbin said.It was not immediately clear whether the FBI report, which will be made available to senators, would be released to the public.Trump’s fellow Republicans control the Senate by a 51-49 margin. If all the Democrats oppose Kavanaugh, Trump cannot afford to lose the support of more than one Republican for his nominee, with Vice President Mike Pence casting a tiebreaking vote. No Republicans have said they will vote against Kavanaugh.Opposition among Americans to Kavanaugh has increased since last week’s hearing, Reuters/Ipsos polling data showed on Wednesday.In the latest seven-day average in a survey of 4,057 US adults, 41 per cent of respondents opposed Kavanaugh, 33 per cent supported him and 26 per cent said they did not know. Opposition to Kavanaugh grew 4 percentage points after the hearing, apparently driven by people who previously were undecided.In a Twitter post on Wednesday, Trump did not back away from his rally comments, instead attacking Kavanaugh’s Democratic critics. Trump said when he goes to political rallies, which are organized by Republicans, he sees that voters are angry at the “vicious and despicable” way Democrats are treating his nominee.At a White House briefing, Trump’s spokeswoman Sarah Sanders defended his remarks in Mississippi and said he was not concerned the comments may have jeopardized the votes of key senators.“The president was stating the facts” about the gaps in Ford’s recollection of the alleged incident, Sanders said.
By The Associated PressGREENWOOD, S.C. (AP) — A South Carolina man who swapped out a town’s segregated World War I plaque says he was tired of the city receiving negative attention for the memorial.Trey Ward spoke Saturday to a group of Democrats in Greenwood about installing a new plaque that listed the names in alphabetical order instead of separating “colored” soldiers, according to The Index-Journal.In a July 7, 2018 photo, State Rep. Anne Parks, D-Greenwood, and local resident Trey Ward stand next to a recently desegregated war memorial in Greenwood, South Carolina. Ward swapped out nameplates of fallen World War I and World War II soldiers listed by race with ones that display the names alphabetically. Ward says he was tired of the city receiving negative attention for the memorial. (Adam Benson/The Index-Journal via AP)“The reason I got involved in this, every time national media came to Greenwood, the first thing they did is go down to the square and write about the monument that lists the valor of dead Black soldiers as ‘colored.’ It was a in a way, our calling card on our Main Street,” Ward said.Several local men had previously filed a lawsuit in 2015 to have the monument revamped, and the mayor had raised money to pay to have a new plaque made.“I really, really do not deserve any credit for this at all. All I really did was turn some screws on a plate, and I stand on the shoulders of a lot of great people in this community that really did this,” Ward told the group of Democrats, who honored him at their monthly meeting.Ward, who accepted a symbolic $1 to do the modification job, also said he was inspired to action by growing up in the era when schools were integrated.State law generally prohibits alterations to monuments without state approval. That law was enacted to protect monuments during debate over removing the Confederate flag from atop the Statehouse.A judge ruled in favor of the veterans group seeking to have the listing on the monument changed. However, the issue was still being litigated when Ward took action.The judge noted the monument was privately owned by the American Legion, even though it sits on public property. The judge said private ownership allows for changes despite the state law known as the Heritage Act.State officials initially asked the judge to reconsider because they think the decision could leave other monuments unprotected. After the monument was changed, the defendants asked the judge to vacate his ruling, saying that after the plaque switch the issue is moot.“Simply put, there now is nothing left for the Court to do and nothing left for the Court to enforce,” the defendants’ attorneys wrote in a motion to vacate a ruling. “The plaques were replaced by a person not a party to this case and, thus, the case was mooted by a non-party without regard to the actual legal issues pending in this case.”
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Explore further According to the press release, the Armada 628 can deliver dual stream 1080p 3D video and 3D graphics performance with quad unified shaders for 200 million triangles per second delivered on ultra-low-power, long battery life smartphones and tablets.The Armada 628 is also the first to incorporate a System-on-a-Chip (SoC) design with three ARM cores and six additional processing engines, totaling nine dedicated core functions. An Armada-equipped smartphone would be able to play 10 hours straight of 1080p HD video or 140 hours of music on a single charge.Some of the key features of the tri-core processor include:• Up to 1.5 GHz for the two main cores and 624 MHz for the third low power core• 1 MB System Level 2 Cache• 1080p dual stream 3D video applications (30 FPS, multi-format)• Ability to project images on multiple simultaneous displays: 2 LCD’s, 1 HDMI, 1 EPD controller• Peripherals supports: USB 3.0 Superspeed Client, MIPI CSI, MIPI DSI, HDMI with integrated PHY, UniPro, Slimbus, SPMIThe Armada 628 is the first mobile CPU to offer USB 3.0. The CPU is compatible with RIM OS, Android, Linux, Windows Mobile, and full Adobe Flash. According to Marvell the CPU is currently available for sampling to customers but there is no word yet on when we can expect it to be incorporated into smartphones or tablets in the U.S. market. Intel Launches New Low-Power Moorestown Chip For Smartphones (w/ Video) (PhysOrg.com) — In a press release this morning Marvell announced the world’s first “ultra-low power, ultra-high performance” 1.5 GHz three-core processor that is the “first to feature 3D graphics performance with quad unified shaders for 200 million triangles per second delivered on mobile devices.” More information: Press release Citation: Marvell announces first triple-core 1.5 GHz mobile processor (2010, September 23) retrieved 18 August 2019 from https://phys.org/news/2010-09-marvell-triple-core-ghz-mobile-processor.html © 2010 PhysOrg.com
‘Pre-booking has started for Passport at Amazon and BlackBerry exclusive stores from Monday itself. Customers pre-booking at Amazon.in would receive a gift card worth Rs 5,000. It will be be available across stores from 10 October for Rs 49,990,’ BlackBerry India Managing Director Sunil Lalvani said at the launch event.BlackBerry Passport has 4.5 LCD touch screen and comes with a three row qwerty keypad which also has capacitative touch features embedded in it. Also Read – I-T issues 17-point checklist to trace unaccounted DeMO cash‘The keypad can be used for typing as well as navigation by swiping fingers on it for functions like delete, moving predictive words function up and down etc,’ Lalvani said. BlackBerry Passport comes with 3450 mAh non-removable battery which company said will support up to 14 hours of talktime in 2G network and video playback of up to 11 hours. The square-shaped handset has 13 megapixel main camera and 2 megapixel front camera. The internal storage capacity of the phone is 32 GB and supports 128 GB of external storage. Also Read – Lanka launches ambitious tourism programme to woo Indian touristsBlackBerry has targeted professionals who have heavy typing requirement through Passport. The phones total length is about 5-inch and width is about 3.5 inch. Though BlackBerry Passport is completely different in terms of design, it may see tough competition from premium smartphones like iPhone 5S, Sony Xperia Z3, HTC M8 etc.Another tough competition for the phone could be Samsung Note 4, which is yet to be launched in India.Before Passport, the company’s most expensive smartphone was Blackberry Q10 launched for about Rs 45,000 in June last year. The handset is now available in the market at around Rs 19,000 — less than half its launch price. The company had to reduce price of its handsets as there was a huge inventory pile up due to less of demand of BlackBerry phones sold at premium price. Lalvani said the price of BlackBerry Passport is going to stay because of its high quality components and specifications.‘We launched Z3 in June and there is no price change till date. We are getting good response. We had two price revisions of Z10 over period of 18 months. Its not a secret. We had to write down some inventory and we are now coming out of it. Passport is competitively and aggressively priced because of its specification,’ Lalvani said.
Kolkata: A 35-year-old woman was killed after she was hit by a private bus near Chiriamore at Barrackpore in North 24-Parganas on Tuesday.Police said the incident took place when the woman was taking her child to her school on Tuesday morning. The seven-year-old child also received injuries and is admitted to hospital.A police officer said the victim, Nitu Gupta, was a local resident. Police came to know after speaking to locals that the accident took place because two buses were racing between each other to get more passengers. Also Read – Speeding Jaguar crashes into Merc, 2 B’deshi bystanders killedOne of the buses failed to control the speed and hit the woman while she was crossing the road. Locals took the woman to a hospital where she was declaredbrought dead.The offending bus was seized but the driver had managed to flee.In two road accidents in Birbhum, one was killed when a motorbike collided head on with a truck at Mohammad Bazar.The road remained close after the accident. In another road accident in Birbhum, a toto collided head on with a truck at Abdarpur and it claimed the life of one person, who was travelingin the toto.The driver of the toto also received severe injuries.
17Jan Rep. VanderWall attends State of the State Categories: VanderWall News,VanderWall Photos State Rep. Curt VanderWall, R-Ludington, is joined by his wife, Diane, to listen to the governor’s State of the State address on the House floor on Tuesday evening.###
15Mar Rep. Hauck bill addressing drone use passes House committee vote The House Committee on Communications and Technology this week advanced a bill proposed by state Rep. Roger Hauck of Union Township as part of a larger legislative package establishing needed state guidelines for drones.Hauck’s bill, House Bill 5495, highlights facilities where use of unmanned aircraft systems will be prohibited under state law. The language refers to knowingly and intentionally interfering with “key facilities” as defined in the Michigan Penal Code, including manufacturing plants, electric or natural gas utilities, correctional sites and telecommunication facilities. Companion legislation sponsored by state Rep. Jim Lower of Cedar Lake offers a sentencing guideline making intentional drone interference with a key facility up to a four-year felony.“Over time, improved education will lead to more educated use,” Hauck said. “My bill allows for a lot of prosecutor discretion because of how new this technology is. Knowledge and intent will be two big things within that discretion. A surveyor who flies a drone over a highway or high voltage power line may not know that he is breaking a law. This proposal improves safety, offers clear deterrents for bad actors, grants leeway for hobbyists and puts rules on the books that can be better recognized and accepted the longer we have this technology.”A 2016 Federal Aviation Administration report estimated 2.5 million drones were being operated nationwide for a variety of purposes, including hobbyist and commercial. That number could grow to a projected 7 million by 2020.A 27-member Unmanned Aircraft Systems Task Force, appointed by Gov. Rick Snyder, began work in April 2017 to develop statewide recommendations on the operation, use and regulation of unmanned aircraft in Michigan. The bills offered largely reflect the task force’s policy recommendations.“There needs to be some definition here where the letter of the law could be clearly identified regarding drone usage,” Hauck said. “There are a lot of hobbyists and recreational drone users and not a lot of education or information on where you can and can’t use them.”The bills within the package, HBs 5494-98, advance to the House floor for further consideration.PHOTO INFORMATION: State Rep. Roger Hauck, of Union Township, provides testimony in support of House Bill 5495 before the House Committee on Communications and Technology on Feb. 13. Hauck’s legislation is part of a bill package aiming to regulate unmanned aircraft at the state level. Categories: Hauck News,News
Social networks’ share of advertising spend in the UK will overtake television ad spend by 2020, according to stats published by eMarketer.The research firm said that come 2020, social network ad spending will account for 20% of all media ad spend in the UK, compared to 17.8% for broadcast TV.As it stands today, social networks’ share of ad spending has overtaken all traditional media formats in the UK, with the exception of TV, and is expected to grow throughout the year.eMarketer estimates that marketers in the UK will spend £3.3 billion on social network advertising in 2018, a 24% increase over 2017.It has also increased its social ad projections since its previous forecast due to diversification in the marketplace, which it says is driving up overall social network user rates and resulting in increased spend.“While Facebook has been losing teen users, Snapchat has been adding them,” said Bill Fisher, eMarketer’s UK senior analyst.“The result is a growing social media market, and one that advertisers are keen to utilise. Media-rich targeting options, with video a particularly big play, make platforms like Snapchat and Instagram especially attractive.”
“We are on the cusp of curing aging.” Those are the words of molecular biologist Dr. William Andrews, founder and CEO of Sierra Sciences, a company with the stated goal to “cure aging or die trying.” In the quote above, which comes from a September 2010 Sierra Sciences press release, Andrews is referring to a nutraceutical (i.e., a natural food-derived product meant to provide health or medical benefits, like vitamin C or folic acid) that his company discovered, known as TA-65. It supposedly slows down the aging process in humans by activating an enzyme called telomerase. Telomerase acts on telomeres—simple repeating sequences of nucleotides (the building blocks of DNA) found at the tips of chromosomes that are important to cell division and replication. Cells must replicate their genes accurately and completely whenever they divide, or the so-called daughter cell will malfunction and die. However, most DNA polymerases (the enzymes that replicate DNA) cannot copy chromosomes all the way to the end. Thus, during each cell division, a small region at the tip of the chromosome (part of the telomere) remains uncopied. So, the telomeres have a crucial function: they act as a buffer zone during cell division, protecting the genes in the chromosome and ensuring that they fully replicate. But there’s a cost: successive divisions cause the telomeres to erode over time. When telomeres erode away, parts of critical genes remain uncopied, eventually spelling death for the cell. Some scientists think that this telomere erosion is what imposes a limit on our lifespans and causes our health to decline as we age; they also think that an answer to this dilemma might be telomerase activation. Telomerase combats telomere erosion by adding telomeric subunits (repeating sequences of nucleotides) to the ends of the chromosome, thereby allowing it to continue to divide intact. The origin of telomerase still remains a mystery. It appears to be critical during human embryonic development, but then fades away. Little is found in the body after birth, for reasons we don’t yet understand. Some scientists, like Dr. Andrews, think telomerase activation could be the cure for aging that his company is looking for, and he views TA-65 as a potential big first step in that direction. According to Andrews: TA-65 is going to go down in history as the first supplement you can take that doesn’t merely extend your life a few years by improving your health, but actually affects the underlying mechanisms of aging. Better telomerase inducers will be developed in the coming years, but TA-65 is the first of a whole new family of telomerase-activating therapies that could eventually keep us young and healthy forever. Well, if proven true, that’s a game-changer, to say the least. Just keep on living until you meet with a fatal accident. Woo hoo! But… hold on. Turns out we shouldn’t get irrationally exuberant just yet. It might not be such a good idea to activate telomerase, after all—because of the role it seems to play in cancer. Cancers can arise when genetic mutations inside a cell cause it to escape from normal controls on replication and migration. The cell and its offspring multiply uncontrollably while invading and damaging nearby tissue. With the presence of telomerase, cancerous cells—which apparently synthesize the enzyme—avoid telomere erosion. They essentially become immortal, dividing for as long as the host survives. A 2012 study by the MD Anderson Cancer Center found that activating telomerase following telomere degradation actually made tumors stronger and more deadly. So alas, TA-65 and telomerase activation might not be the miracle aging “cure” Dr. Andrews was hoping for. But what about other areas of anti-aging/longevity research? There’s a lot of talk these days about humans becoming essentially immortal in the near future, but is the hype supported by any actual research? Let’s see. The Quest for Immortality Continues People have been obsessed with the idea of immortality and living forever for centuries. According to Adam Gollner in The Book of Immortality: The Science, Belief, and Magic Behind Living Forever: The twenty-five-year old Emperor Ai of Jin died in 365 CE, after overdosing on longevity drugs. He wasn’t the last leader to die trying to live forever. The fascination with chemical immortality reached an ironic apogee centuries later, during the T’ang dynasty (618-907 CE), when elixirs poisoned those hoping for precisely the opposite effect. In the late 1300s, legend has it that alchemist Nicolas Flamel created a “sorcerer’s stone” that was then used to produce a potion, the elixir of life, which is said to make the drinker immortal. The idea was so alluring that despite a complete lack of evidence to support the existence of the stone and the elixir, other scientists, including the great Sir Isaac Newton, later tried to replicate Flamel’s results. To no avail. And of course there’s the fabled Fountain of Youth that became associated with Spanish explorer Ponce de León in the early 1500s. We know what happened to him. People today are no different. Not wanting to die is as natural as life itself. Below we’ll present a few interesting discoveries that may (or may not) mark some progress in our quest to live forever. But first we must answer a question. What Is Anti-Aging Medicine? The telomere erosion we talked about earlier certainly plays a part in aging, but most scientists don’t believe that it’s the only factor. They typically view aging as a sort of ongoing cellular wear and tear, where stresses from the environment and inside our cells (such as errors in DNA replication) accumulate throughout life and eventually wear out our cells and tissues. Scientists who search for a modern anti-aging elixir seek to slow down or reverse this process in order to extend both the maximum and average lifespan of people. And even if that doesn’t pan out, advocates of anti-aging medicine contend that at the least, targeting and altering the underlying mechanisms of aging will bring us more efficient ways to deal with age-related conditions like heart disease and many cancers. Now critics dispute the portrayal of aging itself as a disease, of course, but that’s not for us to debate here. Let’s just agree with the commonly stated goal of anti-aging medicine, to “add more years to your life, and life to your years.” Caloric Restriction Mimetics In 1934, scientists at Cornell University found that mice on an abnormally low-calorie diet lived about twice as long as mice who ate as much as they wanted. Scientists have since found that this caloric restriction also lengthens the lives of fruit flies, rats, and even primates, suggesting that this is an avenue worth pursuing in anti-aging medicine. The going (very basic) hypothesis of why these animals live longer is that their bodies treat food scarcity as an extreme type of stress. So they mount a physiological response to cope with the lack of nutrition. And that toughens them up, promoting health and longevity during the time of deprivation, even if that time is significantly extended. Starving yourself in order to get stronger? That sure seems counterintuitive. But the results from numerous experiments make a compelling case. The problem with caloric restriction is that it’s not a very pleasant way to live if you’re fortunate enough to be able to consume a “normal” amount of food on a regular basis (which is between 2,400 and 3,000 calories a day for active males). So scientists are trying to develop drugs (called caloric restriction mimetic drugs) that re-create the anti-aging benefits of caloric restriction without having to change one’s diet. Resveratrol, which is found in the skin of red grapes, was an early favorite in this category. It was first thought to activate a class of enzymes called sirtuins that have been associated with the anti-aging benefits of caloric restriction; but more recent studies have raised serious doubts about whether this compound (and more potent versions of it) actually activates these enzymes and has life-extending benefits. A drug called rapamycin has shown more promise as a caloric restriction mimetic by inhibiting a molecular signaling pathway called TOR. The TOR pathway acts as sort of as a food sensor and helps regulate the body’s response to nutrient availability. Blocking it has been shown on multiple occasions to extend the lifespan of lab knockout mice while keeping them lean and healthy in their later years. Unfortunately, however, the drug’s anti-aging potential in humans is offset by its potent immunosuppressant effects. Overall, research in this field has a long way to go. NAD As we noted above, aging is a sort of cellular wear and tear. According to Dr. David Sinclair of Harvard Medical School, there’s a specific biological signal that accompanies aging and tells cells it’s time to check out. It’s triggered when the cell perceives a lack of oxygen. That makes the mitochondria less efficient at converting fuel (such as glucose) into the ATP needed for cells to function properly. But Sinclair and his colleagues recently found a way to counteract that signal. Using a natural chemical compound called NAD, they were able to revive older cells in mice and make them appear energetic and young again. After receiving NAD for just one week, two-year-old mice tissue came to resemble that of six-month-old mice. “When we give the molecule, the cells think oxygen levels are normal and everything revs back up again,” Sinclair explained. “If a body is slowly falling apart and losing the ability to regulate itself effectively, we can get it back on track to what it was in its 20s and 30s.” Let’s hope. FOXO Molecular biologist Cynthia Kenyon thinks she may have found another of the keys to a long life through her study of tiny worms called C. elegans. By tweaking just one gene in these worms (to simply make it more active), she was able to take two-week-old C. elegans (which is a creaky old age for these things) and make them appear about half that age. And her modified worms lived twice as long as the normal worms. “So they’re like 90-year-old people who look 45,” said Kenyon. The gene Kenyon changed: FOXO. FOXO is a sort of master gene that helps C. elegans protect and repair its tissues (and live longer) by controlling a number of other genes. According to Kenyon: You can think of it as a superintendent of a building. So if you have a building, a nice big building, obviously it has to be maintained. What FOXO does, or the building superintendent does, is to keep the building in good working order. It makes sure that the walls are painted, by hiring painters; it makes sure that the floors are swept. The building superintendent would hire workers to do these different things. What FOXO does, in the cell, is it switches on other genes … I’d say, altogether, there are probably about a hundred worker genes that have very important roles. And, together, what you get is a cell or tissue or an animal that stays in really good working condition for a lot longer. What’s particularly exciting about Kenyon’s work is that the FOXO gene is also found in humans, and that a more protective version of FOXO (as in Kenyon’s modified worms) is associated with longer, healthier lives. Molecular biologist Timothy Donlon found in his studies that if you have this more protective version of FOXO, you have a twofold greater chance of living to 100. And if you have two copies of it, you have a threefold greater chance of living to 100, while remaining healthy. So the gene is indeed associated with adding life to your years and years to your life. If scientists could create a drug to tweak FOXO in humans like Kenyon did in her worms, it seems like we’d have an effective anti-aging medicine on our hands. We could go on with other examples of promising research in anti-aging medicine, but that’s a reasonable sample. It’s the ultimate area of scientific research, really. Moreover, it seems likely to bring benefits to humankind (and also be lucrative for savvy investors) whether aging is a disease that can be “cured” or not. And before leaving you today, I do want to remind you once more about the opportunity to get in on Casey OnePass. It’s just open until Monday, and it’s your only chance to get all eight of our newsletters for a huge discount. Click here to learn more and get started.
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This article is included in Entrepreneur Voices on Company Culture, a new book containing insights from more than 20 contributors, entrepreneurs, and thought leaders.During a Tuesday meeting to discuss an overhaul of Uber’s company culture, former board member David Bonderman proved exactly why the conversations needed to happen in the first place.At the start of the all-hands meeting, Arianna Huffington, who was the first woman to join the company’s board last year, announced the addition of Nestlé executive Wan Ling Martello to the board, increasing the representation of women on the board from 14 to 25 percent.“There’s a lot of data that shows when there’s one woman on the board, it’s much more likely that there will be a second woman on the board,” Huffington noted.That’s when Bonderman interrupted.“Actually what it shows is it’s much likely to be more talking.”In the recording obtained by Yahoo Finance, you can hear Huffington respond at first with awkward laughter. And then her reply: “Oh. Come on, David. Don’t worry, David will have a lot more talking to do as well.”That is not to be the case, as Bonderman resigned shortly after the meeting, which, it bears repeating, was convened to talk about recommendations to change Uber’s culture after allegations of systemic discrimination and sexual harassment.Related: 3 Lessons Every CEO Can Learn From Travis Kalanick’s Emotional Meeting With Uber’s Female EngineersBonderman, the 74-year-old founding partner of investment firm TPG Capital, apologized for the “disrespectful” comment via an internal memo to Uber employees and issued this statement about his departure:”I do not want my comments to create distraction as Uber works to build a culture of which we can be proud. I need to hold myself to the same standards that we’re asking Uber to adopt. Therefore, I have decided to resign from Uber’s board of directors, effective tomorrow morning.”Earlier on Tuesday, CEO Travis Kalanick also announced that he would be taking a leave of absence in order to, as he shared in an email to the company, “take some time off of the day-to-day to grieve my mother, whom I buried on Friday, to reflect, to work on myself, and to focus on building out a world-class leadership team. The ultimate responsibility, for where we’ve gotten and how we’ve gotten here rests on my shoulders,” Kalanick wrote. “There is of course much to be proud of but there is much to improve. For Uber 2.0 to succeed there is nothing more important than dedicating my time to building out the leadership team. But if we are going to work on Uber 2.0, I also need to work on Travis 2.0 to become the leader that this company needs and that you deserve.”Related: Travis Kalanick to Take a Leave of Absence. Here Are 9 CEOs Who Were Fired or Decided to Step Down.So what exactly is Uber 2.0 going to look like?Over the past few months, former attorney general Eric Holder and Tammy Albarrán, partners at law firm Covington & Burling, were tasked with investigating the allegations made by former engineer Susan Fowler and others.They interviewed more than 200 Uber employees and provided a set of recommendations pertaining to how the company should address discrimination, harassment and retaliation and how it could “ensure that its commitment to a diverse and inclusive workplace was reflected not only in the company’s policies but made real in the experiences of each of Uber’s employees.”The recommendations include:Providing more support for the human resources department and establishing clear protocols to track complaints.Mandatory training for senior executives, HR staffers, managers and people in the position to interview prospective employees, particularly around the topics of promoting inclusion and combatting unconscious bias.In terms of recruiting and developing talent, implementing a blind resume review, and increased transparency when it comes to performance reviews and promotions.The prohibition of romantic or intimate relationships between supervisor/subordinates and the consumption of alcohol during work hours, at after work events and at company-sponsored events.An update of discrimination and harassment policies including instituting a zero-tolerance policy for violators of those rules — no matter what position they hold in the company — and explicit protection against harassment from not only other employees, but third-parties the company deals with such as clients to vendors.Related: A 2013 Letter From Uber’s Travis Kalanick Lays Out Sex Rules for Employees at Company PartyA lot of these seem quite standard. But when you look at former engineer Susan Fowler’s blog post and Kalanick’s 2013 Miami letter side by side, the necessity for Holder and Albarrán to explicitly state things such as the importance of “de-emphasizing alcohol as a component of work events,” or that policies should be applied consistently across the company with no special treatment afforded to any one employee is pretty glaring.One passage in particular about Uber’s 14 cultural values speaks volumes about where Uber ran aground. Holder and Albarrán recommended that the company communicate with its employees to reassess and develop a core list of values that are accessible and easy to understand. “Eliminate those values which have been identified as redundant or as having been used to justify poor behavior, including Let Builders Build, Always Be Hustlin’, Meritocracy and Toe-Stepping, and Principled Confrontation; and encourage senior leaders to exhibit the values on a daily basis and to model a more collaborative and inclusive Uber culture,” the recommendation reads. “Leaders who embody these values should be part of the process of redefining Uber’s values and should be role models for other leaders within the company.”Related: Uber CEO Travis Kalanick Says He Needs to ‘Grow Up’ After Video of Argument With a Driver ReleasedUber has long had a reputation for aggressive tactics in its dealings with regulators and competitors. It was seen, for better or worse, as one of the key drivers of its rapid growth. But clearly, as Uber’s experience shows us, growth and success are not one in the same.In an interview with Vanity Fair in 2014, Kara Swisher asked Kalanick about the nature of the interactions with the leaders of the cities (some of whom he described as “really awesome, but most are uninspired”) his business was disrupting.“If you don’t agree with the core principles, which are the premise of that compromise, then you have to have what I call principled confrontation. And so that is the thing that we do that I think can rub some people the wrong way.”If you’re beginning with the premise that compromise doesn’t work for you, and every interaction is a war of attrition, you can let people build all they want, but what exactly are you working toward?If you’re always hustlin’ — though if they do keep that one, I would urge them to restore the “g” to its rightful place — you don’t stop to think about where the pitfalls may be or whether you might be in the wrong. Uber’s experience shows us that is kind of approach is a recipe for collapsing under the weight of your own hubris.Related: If Elon Musk Can Admit His Mistakes, Then So Can YouIn Uber’s San Francisco headquarters, up until this week, the office’s main conference room was called aptly, the War Room. Bloomberg reported that along with the multitude of changes recommended by Covington & Burling, the room is now going to be called the Peace Room. It’s a bit on nose, but you can appreciate the thought, as long as it’s not just lip service.Uber’s culture is not going to change overnight, but now the company seems to have the self-awareness and tools in place to build an environment where values aren’t used, as per Holder and Albarrán’s description, to “justify poor behavior.”So what can we learn from Uber’s newfound emphasis on internal, rather than external growth? Company culture isn’t about perks or empty aphorisms that look good on a T-shirt. Simply, people want to be heard, they want their work to be valued and they want to be treated with respect. When you build your company culture, start there. Entrepreneur Staff 82shares Nina Zipkin Image credit: Spencer Platt | Getty Images 2019 Entrepreneur 360 List Apply Now » Uber June 15, 2017 Uber Needs to Recreate its Company Culture. Here’s What You Can Learn From Its Mistakes. Add to Queue Start by treating people with respect. It’s as simple as that. 8 min read Next Article
Next Article February 12, 2009 Technology The only list that measures privately-held company performance across multiple dimensions—not just revenue. Ustream.TVFounders/ages: Gyula Feher, 30; John Ham, 30; Brad Hunstable, 30Launched: 2007App: A destination platform for streaming live video over the internet; includes co-hosting, chat and hyperlink overlay functionsWhy it works: While YouTube hosts previously recorded videos, Ustream hosts live content, allowing real-time viewing and interaction.Just UptimeFounder/age: Chris Phillips, 25Launched: June 2008App: A website- and server-monitoring application that provides instant e-mail notifications, SMS text alerts and detailed reporting when your website or server is downWhy it works: Sure, a few people out there spend every waking moment online. But for those who don’t, this intuitive app gives them a heads up when issues arise.OoVooCEO/age: Philippe Schwartz, 44Launched: 2007App: An innovative video service for creating video messages, real-time video chats for up to six people and live video callsWhy it works: Communication, whether between friends and family or employees and business partners, has moved online. OoVoo allows face-to-face conversations when being in the same room isn’t possible. Lindsay Holloway Apply Now » This story appears in the March 2009 issue of Entrepreneur. Subscribe » If you’re thinking about creating a web app–whether as a business or to use in your existing business–its construction costs and time can run the gamut. It depends on many factors: how complicated the technology is, what tools you use to build it and so on. But details aside, here are a few web app entrepreneurs who show us it can be done.Iotum CalliflowerFounders/ages: Alec Saunders, 45; Howard Thaw, 52Launched: June 2008App: A meeting tool that bridges businesses and social networks to allow the planning of and participation in interactive conference callsWhy it works: The solution is all-encompassing: It combines high-quality audio conferencing, scheduling, file sharing and collaboration in an easy-to-use interface.MedAppsFounder/age: Kent E. Dicks, 48Launched: 2005App: A two-part application that provides a remote health-monitoring solution; the mobile app collects patient data and readings that a health-care professional monitors via the web appWhy it works: MedApps makes remote health monitoring accessible and inexpensive to the more than 133 million people in the U.S. with at least one chronic condition. Magazine Contributor Yes, You Can Build Your Own Web App 2019 Entrepreneur 360 List Get started nowInspired to build your own web app? These sites can help you take that first step. –shares 2 min read Add to Queue Caspio Coghead Intuit QuickBase Zoho Creator
Your reaction to particularly awful days can make or break future success. The better action to take is to remain as calm as possible. Take quiet time to analyze how far you have come. Think about the twists and turns, and what currently has you stopped in your tracks.Numerous conversations revealed that many almost quit their current endeavors. But one common factor as to why they did not quit helped them to prevail: They enjoy what they do too much! Ironically, it has become their way of life.As uncertainty hits, follow these two suggestions:Take the time needed to uncover the better route.Convert a negative frame of mind into a positive.Reframe the situationOne sales technique referred to as “Reframing” applies very well to difficult situations. Whether personal or trying to work with a client, the first step is to figure out where the discontent originates. Upon recognizing the misstep, it becomes easier to work together to find the better solution. By asking a series of questions such as, “What if…” the improved path begins to reveal itself.On the personal side, moving from negative to positive thought is the beginning step for improvement. The change in attitude makes an enormous difference in providing increased opportunity to save the day.The day that you find you are doubting yourself, take private time to consider “the why” that is. Most likely, one of your peers will have had a similar experience. Have a conversation about how they dealt with it and ask for recommendations on how to handle. Their insights won’t necessarily apply or even matter. It’s more about the conversation itself. Just by unleashing the dilemma is all it takes to get back to full steam ahead. As others see you meeting negativity and obstacles head on, they come to admire your steadfast personal brand.Tips:When negativity hits, stop to examine the origin.Decide whether changes need to be made.Should changes be in order, decide whether they are minor or major.Begin the process by eliminating the no longer needed.Create a list of what needs to be fixed.Prioritize the list in order of immediate need.Re-energize yourself and/or business by communicating. –shares Image credit: Shutterstock Fireside Chat | July 25: Three Surprising Ways to Build Your Brand Learn from renowned serial entrepreneur David Meltzer how to find your frequency in order to stand out from your competitors and build a brand that is authentic, lasting and impactful. The day that you find you are doubting yourself, take private time to consider why that is. Elinor Stutz Opportunity CEO of Smooth Sale, Author & Inspirational Speaker September 17, 2016 Next Article Add to Queue 2 min read This story originally appeared on Personal Branding Blog Transform Dark Days into Opportunity Enroll Now for $5
Luokung Technology Corp. (LKCO) (“Luokung” or the “Company”), a leading global spatial-temporal big-data technology company and a leading interactive location-based services company in China, announced that it has signed a stock purchase agreement to acquire 67.36% of Beijing BotBrain AI Technology Ltd and BOTBRAIN AI LIMITED (collectively “BotBrain “).The Company will invest RMB 20 million to BotBrain and will issue 804,162 ordinary shares at USD $7 per share to the former institution investors of BotBrain to obtain 67.36% (the “Acquisition”). The 32.64% share equity of BotBrain will be remained by Mr. Xueyu Lu, the founder and CEO of BotBrain, along with BotBrain ‘s core team members. After the Acquisition, Mr. Lu will continue as CEO of BotBrain AI.BotBrain was established in January 2016, and it has been becoming an advanced provider for intelligent content solutions in China. It’s artificial intelligence algorithms and technology are applied in Chinese semantic analysis, intelligent voice interaction, knowledge graph learning, personalized contents recommendation and other related big data analysis.There are two independent business brands in BotBrain. “Max” content brain is an AI content management and operation platform, which provides AI solutions based on its content services. “BotBrain Zhiyu” is an AI knowledge learning assistant system.Marketing Technology News: Acquia Acquires Mautic to Deliver First-Ever Open Marketing CloudBotBrain has been serving many well-known enterprises based in China, including People’s Daily Overseas, ChinaNews, Kaishu Story, Baby Tree, Baofeng, Bank of China, State Grid, FAW, CreditEase, Facebank and Kingsoft Cloud etc., which involve various industries including media, mobile internet, banking, automobile, financial services, retails and energy.BotBrain has started the cooperation with the Company in technology supports prior the Acquisition, it provides intelligent geographic information algorithms service for us, and Its technology of semantic analysis, knowledge graph and personalized contents recommendation significantly supports the LBS service of Luokung. After the Acquisition, BotBrain will put more investment in the research of intelligent spatial temporal data algorithm and application. BotBrain will provide critical intelligent technologies and application experiences to support our LBS business, personalized full-vector map, and enable us to improve the services we provide to mobile Internet industry and users. Therefore, the Company’s LBS business platform is able to gain a greater competitive advantage.Marketing Technology News: Mareana Named a 2019 Gartner Cool Vendor in Artificial Intelligence Across the Supply ChainThe founder and CEO of BotBrain, Mr. Lu Xueyu processes more than 40 patents relating to the contents intelligence service algorithms. Mr. Lu has more than 13 years experiences in big data and AI industry, he has had an in-depth comprehension and long-term practice in big data, AI and personalized recommendation and Mr. Lu is one of the earliest practitioners in this field in China. Mr. Lu worked in Tencent, Alibaba Youku and Xiaomi and was responsible for the construction and management of big data and artificial intelligence teams, gained many successful implementation experiences for the establishment of big data and recommendation systems. In 2006 in Tencent, Mr. Lu took the lead in using artificial intelligence technology in virus discovery, effectively helped Tencent to protect nearly 1 billion QQ users’ account information security. In Youku, Mr. Lu served as technical director and set up the big data and personalized recommendation system for videos, the system was able to proceed more than 100 billion data daily, it was the system with the highest recommendation accuracy in the field of video websites at that time. During the time in Xiaomi, Mr. Lu was the technical director and was in charge of Xiaomi’s data workshop, he was also responsible for the Xiaomi ecological big data business.Marketing Technology News: RevJet Announces Results of Second Ad Experience Sentiment Report Revealing Change in Sentiment, Behavior of Online Consumers Luokung Technology Corp. Announces to Acquire Artificial Intelligence Company PRNewswireMay 14, 2019, 2:55 pmMay 14, 2019 AcquisitionAIBotBrain AI Technologycontent managementLuokung TechnologyMarketing Technology NewsNews Previous ArticleTechBytes with Adam Solomon, Chief Marketing Officer at LotameNext ArticleGoogle Selects Webpals Mobile to Join App Campaign Partner Program
Unstoppable Domains, a software company building domains on blockchains, today announced which 60 .zil domains it will auction on June 27. These domains represent the top 60 most watched Zilliqa domain names on the Unstoppable Domains website. The top domain, bitcoin.zil, has already attracted 505 potential buyers.“We are excited to see growing enthusiasm for blockchain domains,” said Matthew Gould, Unstoppable Domains CEO. “These domains provide two very critical benefits to users: they enable people to send crypto to a single human readable name, and they offer a platform to create uncensorable websites. The concepts of free speech and growing the crypto community are really resonating with our customer base.”Marketing Technology News: Triton Digital Integrates Centro’s Basis Platform with the a2x Programmatic Marketplace.Zil domains have seen high demand over the past 3 months, even though top domains have yet to be released. Users can, however, watchlist the domains they are most interested in bidding on during the coming public auction. Here are the top 60 most watchlisted domains:Which domains will be up for auction?1. bitcoin2. crypto3. porn4. blockchain5. money6. insurance7. gold8. cars9. hotels10. satoshi11. bra12. zil13. usa14. bank15. wallet16. beer17. ethereum18. carinsurance19. lasvegas20. pay21. trump22. weed23. travel24. toys25. pizza26. cannabis27. xxx28. litecoin29. privatejet30. music31. xrp32. fb33. z34. shop35. 36036. coffee37. coin38. cash39. vacationrentals40. porno41. hotel42. payme43. booking44. diamond45. insure46. game47. exchange48. 149. ripple50. donaldtrump51. abc52. cardano53. auction54. shoes55. ai56. car57. we58. domain59. elonmusk60. israelThe auction will be split into two phases. During phase I, the 60 most watchlisted domains will be available for a buy now price of $10,000 each. Domains can be purchased using bitcoin, ethereum, litecoin, and bitcoin cash.Marketing Technology News: Mindtree to Showcase Contextual, Real-Time Solutions for Personalized Traveler Experiences at HITEC MinneapolisDuring phase II, domains can only be purchased with Zilliqa.Bidding will start between $10 and $1,000 depending on the price of the domain in the pre-order phase. Each subsequent bid must be at least 5 percent greater than the previous bid. If a person is outbid, they will immediately get their funds returned. New bids will add additional time (~1 hour) to the auction to prevent auction sniping. Also, bidding will be capped at $10,000 per domain. Anyone in the world can participate and anyone in the world can watch the auctions as they happen.Marketing Technology News: CoreMedia Announces CoreMedia Content Cloud – Marketing Connector on Salesforce AppExchange, the World’s Leading Enterprise Cloud Marketplace Marketing TechnologyMatthew GouldNewsUnstoppable DomainsZilliqa Domain Previous ArticleMarTech Interview with Duncan Stockdill, Co-Founder and CEO at CapsuleNext ArticleFranklin Sports Selects CommerceIQ To Empower Their E-Commerce Team To Manage Amazon Holistically Unstoppable Domains Announces the Top 60 Zilliqa Domain Names Up for Auction Business WireJune 19, 2019, 1:45 pmJune 19, 2019
Source:https://canal.ugr.es/noticia/obesity-and-food-restrictions-proven-to-be-associated-with-less-food-enjoyment/ Reviewed by Alina Shrourou, B.Sc. (Editor)Nov 13 2018Researchers from the University of Granada (UGR) belonging to the Mind, Brain and Behavior Research Center (CIMCYC, from its name in Spanish) and the Faculty of Business and Economics have proven that adolescents who suffer from obesity feel less food enjoyment than those who have a normal weight. In addition, their work reveals that even trivial restrictions on food intake (that is, temporary diets) are associated with a reduction in pleasure.For this work, published in the journal Food Quality and Preference, a large sample of 552 adolescents between 11 and 17 years old from several high schools in Granada has had their emotional reactions analyzed during the visualization of images of sweet foods.Related StoriesResearchers propose new avenue in the search for anti-obesity drugsSupervised fun, exercise both improve psychosocial health of children with obesityNew technique reduces postoperative deficit of oxygen in the blood in patients with morbid obesityThus, the researchers observed that those adolescents who reported different types of dietary restrictions (different types of diet, dieting very often, skipping breakfast, eating less frequently, etc.), along with those who were obese and those who had unhealthy behaviors unrelated to food (such as smoking or having insufficient sleep), felt less pleasure, attraction and desire to eat the highly palatable foods they were looking at (images of sweets, donuts, ice‑creams, chocolate crêpes, etc.).As explained by Laura Miccoli, main author of this study, “adolescence, typically associated with greater body dissatisfaction, is a key stage for the development of risky eating behaviors, related both to uncontrolled restrictions on food intake -which may lead to to the development of eating disorders- and with the stabilization of overweight and obesity.” Hence the importance of studies that approach both food‑related disorders from an integrative perspective.A pioneering studyNot in vain, the research led by the UGR is the first study that has examined the adolescents’ emotions toward sweet food cues based on a constellation of risk behaviors, related to both obesity and eating disorders.In the light of the results obtained, the UGR scientists point out that those adolescents who feel more pleasure or enjoyment when eating “have a healthy relationship with food, and this pleasure may be a possible protective factor against eating and weight‑related disorders.”Therefore, “consistent with recent prevention strategies, it is important to change the perspective on the enjoyment of food with respect to the prevention of obesity, banishing the idea that we should avoid the pleasure of eating. On the contrary: we should take advantage of it, and make food enjoyment -the ‘slow food movement’- a tool for healthy eating,” Miccoli points out.
70% of HGSC relapse despite treatment, becoming resistant to chemotherapy, which makes the new discovery a true potential breakthrough in the treatment of this tumor.All life at cellular and organism level depends upon thousands of life processes that provide and degrade a range of chemicals required for proper function of the cells and tissues. These intricately interdependent processes together they make up the body’s metabolism. By Dr. Liji Thomas, MDJul 14 2019A new study shows that targeting a specific protein found within quickly spreading high-grade serous carcinomas (HGSC) of the ovary could help contain these cancers. HGSC is the most common and deadly form of epithelial ovarian cancer, which is itself the deadliest cancer of the female reproductive tract. When HGSC spreads outside the ovaries, within the peritoneal cavity, it forms detached balls called spheroids, which may look and act differently from the adherent cells of the primary tumor.The study is published in the current issue of the journal Molecular Cancer Research. However, as researcher Erika Dahl explains, “A hallmark of cancer cells is that their metabolic processes are often different from normal, healthy cells.” This is called metabolic reprogramming. As one of the outcomes, study author Katherine Aird says, “Cancer cells can grow forever without stimulus.” Cancer cell Illustration. Image Credit: Jovan Vitanovski / Shutterstock The good news about the newly discovered protein is that it can be inhibited, thus inactivating cell processes within ovarian cancer cells to switch them from a constitutively proliferative cell cycle to one which results in senescence, or going to sleep. The key role of the protein was identified on cell culture experiments by researchers at Penn State College of Medicine.The current study focused on teasing out the differences in the metabolism of ovarian cancer cells by comparing them with cells from a normal fallopian tube.The route used to achieve this was quantitative spectrometry, which helped analyze the metabolites produced by various cellular pathways in the two type of tissue. Among the differences, it was revealed that cancer cells utilized glucose, a form of sugar, via the key energy cycle called the citric acid cycle, far more often, as against the more common use of an oxygen-requiring pathway called aerobic glycolysis. This accounts for the presence of a high level of citric acid activity in all high-grade serous ovarian cancer cells. Related StoriesStudy reveals link between inflammatory diet and colorectal cancer riskVirus killing protein could be the real antiviral hero finds studyNew study to ease plight of patients with advanced cancerThis means that many therapies which inhibit the breakdown of glucose (glycolysis) to destroy cancer cells may be quite ineffective. Dahl commented that this could often result, in fact, in the production of toxins that harm normal healthy tissue.Instead, the team in the current study looked at the effects of inhibiting the wildtype or normal form of an enzyme, isocitrate dehydrogenase 1 (IDH 1), which plays a vital part in the citric acid cycle. They selected this protein because it was the only one in this pathway that is expressed at higher levels in both adherent and spheroid tumor cells. Increased activity of this enzyme severely impacts progression-free survival, which is an important outcome measured in assessing the effectiveness of any cancer therapy.Mutants of this protein are common in other tumors, but the wildtype form is typically present in cells within HGSC. The researchers hypothesize that the presence of this enzyme is an important advantage to these cells, and its inhibition is a key step to inducing senescence.The researchers found that suppressing the work of this protein stopped cell division completely by suppressing the activity of multiple other genes, inhibiting vital metabolic pathways. Both adherent cells of the primary tumor, and spheroid cells of secondary HGSC, become senescent when the wildtype IDH 1 enzyme is inhibited. Thus, this could be an excellent way to treat HGSC at all stages. This is an important consideration, as ovarian cancers are rarely diagnosed at early stages.While there are already FDA (US Food and Drug Administration)-approved drugs against one of the mutant forms of this enzyme, the team wondered whether they would work against the wildtype form as well. They found that one did, and this is now a part of their continued research agenda.Aird says, “One of our long-term goals is to try and repurpose this already-approved drug as a treatment for this form of ovarian cancer.” Besides adapting existing drugs against the enzyme to fight this type of cancer, the researchers want to examine the differences in the metabolic functioning of normal and HGSC cells more closely. Another goal is to examine the effectiveness of combining IDH 1 inhibitors with other treatments. Journal reference:Targeting IDH1 as a Prosenescent Therapy in High-grade Serous Ovarian Cancer, Erika S. Dahl, Raquel Buj, Kelly E. Leon, Jordan M. Newell, Yuka Imamura, Benjamin G. Bitler, Nathaniel W. Snyder and Katherine M. Aird, Mol Cancer Res June 17 2019 DOI: 10.1158/1541-7786.MCR-18-1233, http://mcr.aacrjournals.org/content/early/2019/06/17/1541-7786.MCR-18-1233
Explore further Britain called for a first-of-its-kind watchdog for social media that could fine executives and even ban companies. And a European Union parliamentary committee approved a bill giving internet companies an hour to remove terror-related material or face fines that could reach into the billions.”We are forcing these firms to clean up their act once and for all,” said British Home Secretary Sajid Javid, whose department collaborated on Britain’s proposal.Opponents warned the British and EU measures could stifle innovation and strengthen the dominance of technology giants because smaller companies won’t have the money to comply. That, in turn, could turn Google and Facebook into the web’s censors, they said.The push to make the big companies responsible for the torrent of material they carry has largely been driven by Europeans. But it picked up momentum after the March 15 mosque shootings in New Zealand that killed 50 people and were livestreamed for 17 minutes. Facebook said it removed 1.5 million videos of the attacks in the 24 hours afterward.The U.S., where government action is constrained by the First Amendment right to free speech and freedom of the press, has taken a more hands-off approach, though on Tuesday, a House committee will press Google and Facebook executives on whether they are doing enough to curb the spread of hate crimes and white nationalism.Australia last week made it a crime for social media platforms not to quickly remove “abhorrent violent material.” The offense would be punishable by three years in prison and a fine of 10.5 million Australian dollars ($7.5 million), or 10% of the platform’s annual revenue, whichever is larger. New Zealand’s Privacy Commissioner wants his country to so the same.The British plan would require social media companies such as Facebook and Twitter to protect people who use their sites from “harmful content.” The plan, which includes the creation of an independent regulator funded by a tax on internet companies, will be subject to public comment for three months before the government publishes draft legislation. Citation: Facebook, Google face widening crackdown over online content (2019, April 9) retrieved 17 July 2019 from https://phys.org/news/2019-04-facebook-google-widening-crackdown-online.html Tech giants like Facebook and Google came under increasing pressure in Europe on Monday when countries proposed stricter rules to force them to block extreme material such as terrorist propaganda and child porn. In this April 18, 2017 file photo, conference workers speak in front of a demo booth at Facebook’s annual F8 developer conference, in San Jose, Calif. The U.K. for the first time on Monday April 8, 2019, proposed direct regulation of social media companies, with senior executives potentially facing fines if they fail to block damaging content such as terrorist propaganda or images of child abuse. (AP Photo/Noah Berger, File) “No one in the world has done this before, and it’s important that we get it right,” Culture Secretary Jeremy Wright told the BBC.Facebook’s head of public policy in Britain, Rebecca Stimson, said the goal of the new rules should be to protect society while also supporting innovation and freedom of speech.”These are complex issues to get right, and we look forward to working with the government and Parliament to ensure new regulations are effective,” she said.Britain will consider imposing financial penalties similar to those under the EU’s online data privacy law, which permits fines of up to 4% of a company’s annual worldwide revenue, Wright said. In extreme cases, the government may also seek to fine individual company directors and prevent companies from operating in Britain.Under the EU legislation that cleared an initial hurdle in Brussels, any internet companies that fail to remove terrorist content within an hour of being notified by authorities would face similar 4% penalties. EU authorities came up with the idea last year after attacks highlighted the growing trend of online radicalization.The bill would apply to companies providing services to EU citizens, whether or not those businesses are based in the EU’s 28 member countries. It still needs further approval, including from the full European Parliament.It faces heavy opposition from digital rights organizations, tech industry groups and some lawmakers, who said the 60-minute deadline is impractical and would lead companies to go too far and remove even lawful material.”Instead, we call for a more pragmatic approach with removals happening ‘as soon as possible,’ to protect citizens’ rights and competitiveness,” said EDIMA, a European trade group for new media and internet companies.Opponents said the measure also places a bigger burden on smaller internet companies than on giants like Facebook and Google, which already have automated content filters. To help smaller web companies, the bill was modified to give them an extra 12 hours for their first offense, a measure opponents said didn’t go far enough.Mark Skilton, a professor at England’s Warwick Business School, urged regulators to pursue new methods such as artificial intelligence that could do a better job of tackling the problem.”Issuing large fines and hitting companies with bigger legal threats is taking a 20th-century bullwhip approach to a problem that requires a nuanced solution,” he said. “It needs machine learning tools to manage the 21st-century problems of the internet.”Wright said Britain’s proposed social-media regulator would be expected to take freedom of speech into account while trying to prevent harm.”What we’re talking about here is user-generated content, what people put online, and companies that facilitate access to that kind of material,” he said. “So this is not about journalism. This is about an unregulated space that we need to control better to keep people safer.” UK takes aim at social networks that fail to quash ‘hateful’ content This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. © 2019 The Associated Press. All rights reserved.