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Salvage of Chiron flu vaccine unlikely

first_imgOct 9, 2004 (CIDRAP News) – Lester Crawford, acting director of the US Food and Drug Administration (FDA), appearing before the House Committee on Government Reform yesterday, said he was pessimistic about the possiblility that any of the 48 million doses of influenza vaccine expected in the United States from Chiron Corp. can be salvaged for use this flu season, according to new service reports. FDA experts remain in England this weekend to make the final determination, with visits planned to the Liverpool plant whose manufacturing license was revoked earlier in the week, effectively cancelling half the US’s supply.Several lots of Chiron’s vaccine, Fluvirin, were found to be contaminated, leading to suspension of Chiron’s manufacturing license by Britain’s Medicines and Healthcare Products Regulatory Agency (MHRA). It came out this week that the organism implicated in the contamination is Serratia, a bacterium that lives in water, soil, plants, and animals and is not dangerous if encountered on environmental surfaces.When Serratia is harbored in medical equipment, however, it can cause illness and has been documented in numerous outbreaks (see link below for example of bronchoscope contamination). In commenting on the Chiron situation, Dr. Robert Belshe, director of the division of infectious diseases and immunology at St. Louis University, conjectured that it may have come from bottles, vials, or rubber stoppers, according to a Wall Street Journal story.Aventis Pasteur, the other large supplier of inactived flu vaccine for the United States, has said it will be able to supply 55.4 million doses of its Fluzone, according to an Associated Press story. This is somewhat more than it had originally commited to, but doses beyond that cannot be made in time for this year’s flu season.MedImmune, makers of FluMist, an inhalable form of flu vaccine, was asked by the Center for Disease Control and Prevention to provide more than the 1.5 million doses promised. The company has said it can provide nearly 1 million extra doses by late November, according to the Associated Press. The doses will come from already-produced frozen bulk vaccine.FluMist is FDA-approved for use only in people aged 5 to 49, which is the group least in need of vaccination. Four million doses were produced for the 2003-2004 flu season but much of that supply went unused, partly because of its higher cost in comparison with injected vaccines. MedImmune has cut the cost of FluMist this year and is also working on a new formulation it expects to be available in 2007.Public health officials are working quickly to track down the doses of vaccine that are already in the hands of distributors and providers to ascertain how the unexpectedly limited supply can best be made available to the populations most in need of vaccinations (see link below to interim guidelines).See also:2003 New England Journal of Medicine article on Serratia contamination of brochoscopes [Abstract]CDC interim recommendations for flu vaccinehttp://www.cdc.gov/mmwr/preview/mmwrhtml/mm5339a6.htmlast_img read more

Highgate Hill inner-city jungle hideaway

first_imgLook out on the surrounding gully from the moment you wake up.More from newsParks and wildlife the new lust-haves post coronavirus15 hours agoNoosa’s best beachfront penthouse is about to hit the market15 hours agoMs Burkett said the house consisted of three different pavilions across two levels.“It has a lot of glass in addition to there being outdoor spaces, so when you’re inside you still have that connection to the outside,” Ms Burkett said. The house uses timber and glass to maintain a connection with the outdoors.When asked if she had undertaken any renovation of the property, Ms Burkett said they completed a project annually but always with the integrity of the original design at the front of their minds.“We’ve been very passionate about conserving and maintaining it,” she said.“Every year we’ve taken on a project but always respecting the design, because in our view, that’s the true value of the house.” This is the perfect place to get some inspiration for your latest project.Ms Burkett said the library was her favourite area in the home.“My favourite is the library area.“One of its walls slides open and you can look down the gully toward the river and at night, you can see the lights shining on the river.” The house at 1 Derby St, Highgate Hill, is for sale.NESTLED in a lush slice of inner-city land, this architectural wonder is the ultimate hideaway.The house at 1 Derby St, Highgate Hill, was commissioned by its original owners and designed by architects Andresen and O’Gorman.center_img Is there anything more relaxing than curling up by the fire with a book?Greta Burkett bought the house a decade ago and the privacy of the property was a major drawcard.“It’s very close to the city but when you walk into the property, you feel as though you could be miles away,” Ms Burkett said. The bathrooms follow the theme.She said she will fondly remember time spent with family and friends at the house, as well as becoming a part of the close-knit community, who were keen to conserve the nature around them.“All of the neighbours have been wonderful, we’ve formed really lovely friendships with all of them.“They’re all passionate about the gully as well.”Video Player is loading.Play VideoPlayNext playlist itemMuteCurrent Time 0:00/Duration 0:51Loaded: 0%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -0:51 Playback Rate1xChaptersChaptersDescriptionsdescriptions off, selectedCaptionscaptions settings, opens captions settings dialogcaptions off, selectedQuality Levels720p720pHD576p576p432p432p270p270pAutoA, selectedAudio Tracken (Main), selectedFullscreenThis is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.This is a modal window. This modal can be closed by pressing the Escape key or activating the close button.Close Modal DialogThis is a modal window. This modal can be closed by pressing the Escape key or activating the close button.PlayMuteCurrent Time 0:00/Duration 0:00Loaded: 0%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -0:00 Playback Rate1xFullscreenStarting your hunt for a dream home00:51last_img read more